
$141 Cheap flight deals from Des Moines (DSM) to Santa Rosa (SFO)
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This Weekend's Flight Deals from Des Moines to Santa Rosa
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $141 One Way, $161 Round Trip from Des Moines to Santa Rosa
Prices starting at $161 for return flights and $141 for one-way flights to Santa Rosa were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Santa Rosa economy flight packages

Bay Landing San Francisco Airport Hotel
Nov 3 - Nov 6
Des Moines (DSM) to San Francisco (SFO)
Reviewed on Sep 22, 2025

1 Hotel San Francisco
Nov 15 - Nov 21
Des Moines (DSM) to San Francisco (SFO)
Reviewed on Sep 23, 2024

Hilton Garden Inn San Mateo
Nov 15 - Nov 21
Des Moines (DSM) to San Francisco (SFO)
Reviewed on Dec 4, 2023
More About Flying To Santa Rosa from Des Moines
Route Information for Flights from Des Moines to Santa Rosa
Origin Airport IATA Code | DSM |
---|---|
Destination Airport IATA Code | SFO |
Distance | 1546 mi |
Direct Flight Airlines | United Airlines |
Earliest Flight Arrival | 12:05AM UTC |
Latest Flight Arrival | 12:05AM UTC |
Des Moines to Santa Rosa
Orbitz guarantees you low prices on flights from Des Moines to Santa Rosa. In addition to low fares on Des Moines to Santa Rosa flights, Orbitz offers fantastic savings on hotels, cruises, vacation packages, and more.
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Besides helping you fly for the lowest fares, Orbitz lets you earn miles for your frequent flyer program for certain flights from Des Moines to Santa Rosa. If you are a member of the frequent flyer or loyalty program offered by the airline you booked through Orbitz or a partner airline’s, simply add your frequent flyer number to your Orbitz reservation to get credit for your Des Moines to Santa Rosa flights.
Travel Planning Made Easy
We help take some of the anxiety out of your Des Moines to Santa Rosa flights with free flight alerts. We will let you know of flight changes and delays to your flights from Des Moines to Santa Rosa by email, voicemail, or text messages to your mobile phone. Alerts can also be sent to up to six other contacts to keep family and business teams informed.
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Frequently asked questions
Flights from Des Moines
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Des Moines Airports
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.