$192 Cheap flight deals from Panama City (PTY) to Mexico City (MEX)

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This Weekend's Flight Deals from Panama City to Mexico City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Aug 1 - Fri, Aug 8
PTY
Tocumen Intl.
MEX
Mexico City Intl.
$343 Roundtrip, found 3 hours ago
$343
Roundtrip
found 3 hours ago
Select Aeromexico flight, departing Fri, Aug 1 from Tocumen Intl. to Mexico City Intl., returning Fri, Aug 8, priced at $343 found 3 hours ago

Airfares from $192 One Way, $342 Round Trip from Panama City to Mexico City

Prices starting at $342 for return flights and $192 for one-way flights to Mexico City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Nov 30 - Thu, Dec 11
PTY
Panama City
MEX
Mexico City
$342 Roundtrip, found 1 day ago
$342
Roundtrip
found 1 day ago
Select Copa flight, departing Sun, Nov 30 from Panama City to Mexico City, returning Thu, Dec 11, priced at $342 found 1 day ago
Tue, Dec 9 - Tue, Dec 16
PTY
Panama City
MEX
Mexico City
$343 Roundtrip, found 1 hour ago
$343
Roundtrip
found 1 hour ago
Select Aeromexico flight, departing Tue, Dec 9 from Panama City to Mexico City, returning Tue, Dec 16, priced at $343 found 1 hour ago
Wed, Sep 17 - Mon, Sep 22
PTY
Panama City
MEX
Mexico City
$363 Roundtrip, found 1 hour ago
$363
Roundtrip
found 1 hour ago
Select avianca flight, departing Wed, Sep 17 from Panama City to Mexico City, returning Mon, Sep 22, priced at $363 found 1 hour ago
Thu, Nov 13 - Mon, Nov 17
PTY
Panama City
MEX
Mexico City
$364 Roundtrip, just found
$364
Roundtrip
just found
Select Aeromexico flight, departing Thu, Nov 13 from Panama City to Mexico City, returning Mon, Nov 17, priced at $364 just found
Sun, Nov 2 - Tue, Nov 18
PTY
Panama City
MEX
Mexico City
$370 Roundtrip, found 1 day ago
$370
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Sun, Nov 2 from Panama City to Mexico City, returning Tue, Nov 18, priced at $370 found 1 day ago

Mexico City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Casa Decu
4.0-star property

Casa Decu

9.4/10 Exceptional! (726 reviews)

Sep 3 - Sep 7

4 night stay

Panama City (PTY) to Mexico City (MEX)

Copa • Roundtrip • Coach
Save 100% on your flight
per person
found 11 hours ago
Great boutique hotel located in a cute neighborhood in La Condensa. Staff hospitality was amazing with provided great restaurant recommendation and quick response. Accessible to cute cafes and delicious restaurants…all within walking distance. I would definitely recommend this hotel.

Reviewed on Sep 10, 2023

Casa de la Luz Hotel Boutique
4.0-star property

Casa de la Luz Hotel Boutique

9.6/10 Exceptional! (369 reviews)

Sep 3 - Sep 7

4 night stay

Panama City (PTY) to Mexico City (MEX)

Copa • Roundtrip • Coach
Save 100% on your flight
per person
found 11 hours ago
The hotel is a diamond within a scruffy neighborhood. A wonderful oasis within the historic core of Mexico City. It's sited on a quarter-block park which removes it a touch from the roar of traffic. Staff is fantastic and the included breakfast is unparalleled.

Reviewed on Feb 14, 2025

Gran Hotel Ciudad de Mexico Zocalo View
4.5-star property

Gran Hotel Ciudad de Mexico Zocalo View

9.8/10 Exceptional! (1,006 reviews)

Sep 3 - Sep 7

4 night stay

Panama City (PTY) to Mexico City (MEX)

Copa • Roundtrip • Coach
Save 100% on your flight
per person
found 11 hours ago
The people at the front desk was really nice and very welcoming, so from start till now has been buried awesome

Reviewed on Jul 10, 2025

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More About Flying To Mexico City from Panama City

Route Information for Flights from Panama City to Mexico City

Origin Airport IATA Code
PTY
Destination Airport IATA Code
MEX
Distance
1498 mi
Direct Flight Airlines
Emirates, Copa Airlines, Aeromexico
Earliest Flight Arrival
5:10PM UTC
Latest Flight Arrival
6:00AM UTC

Panama City to Mexico City

Great Deals on Flights From Panama City to Mexico City

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Frequently asked questions

Are there non-stop flights from Panama City to Mexico City?
There most certainly is. Copa Airlines offers direct flights from PTY to MEX, which makes going from Panama City to Mexico City a cinch.
What is the shortest flight from Panama City to Mexico City?
The quickest flight time from Tocumen Intl. Airport (PTY) to MEX is around 3 hours and 47 minutes. Order a wine from the drink cart, write in your travel journal or make friends with your seat mate — you'll have the time on this medium-haul journey.
What airlines fly from Panama City to Mexico City most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Mexico City route. You can select from 152 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.