$106 Cheap flights to South America

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Top places to visit in South America

Cheap flights to South America from $106 One Way, $248 Round Trip

$248 return flights and $106 one-way flights to South America were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
MIABogotáMarch 29 to April 7$321
JFKQuitoMarch 27 to April 6$465
MIAQuitoMarch 28 to April 4$527
MIACordobaMarch 29 to April 7$611
JFKLimaMarch 27 to April 20$706
MIABuenos AiresMarch 28 to April 3$754
MIASalvadorMarch 29 to April 4$972
MIABelemMarch 28 to April 14$1,127
LHRBogotáMarch 29 to April 7$1,497
JFKSalvadorMarch 29 to April 3$1,686
LGWSao PauloMarch 28 to April 19$1,712
LHRQuitoMarch 29 to April 15$1,776
LGWSantiagoMarch 27 to April 12$1,919
BKKBuenos AiresMarch 28 to April 8$2,095
BKKSantiagoMarch 29 to April 2$3,678
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic South America Accommodation Deals

Padama Hotel

Padama Hotel

3.5 out of 5
Av. El Olivar 1238 Callao Lima
Fully refundableReserve now, pay when you stay
$26 nightly
The price is $26 total per night from Mar 22 to Mar 23
$26 total
Mar 22 - Mar 23
Stay at this hotel in Callao. Enjoy free WiFi, private hot tubs, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Plaza ...
Opens in a new windowPadama Hotel
Hotel Dorado Plaza Centro Histórico

Hotel Dorado Plaza Centro Histórico

3 out of 5
Carrera 9 31-72 Cartagena Bolivar
Fully refundableReserve now, pay when you stay
$79 nightly
The price is $79 total per night from Apr 11 to Apr 12
$79 total
Apr 11 - Apr 12
Stay at this hotel in Cartagena. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.6/10 Good! (513 reviews)
This was not my choice in booking as my original choice was cancelled for some odd reason or another. No hot water and if we wanted hot water , there was an additional fee / upgrade nightly fee

Reviewed on Mar 2, 2026

Opens in a new windowHotel Dorado Plaza Centro Histórico
Quito Airport Suites

Quito Airport Suites

2.5 out of 5
E8-233 Conector Alpachaca Tababela Pichincha
$60 nightly
The price is $65 total per night from Mar 23 to Mar 24
$65 total
Mar 23 - Mar 24
Book a stay at this family-friendly guesthouse in Tababela. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Opens in a new windowQuito Airport Suites
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Altura Suites

Altura Suites

4 out of 5
Merced 562, departamento 1006A Santiago Region Metropolitana
Stay at this aparthotel in Santiago. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Costanera Center and Parque Arauco Mall are ...
Opens in a new windowAltura Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top South America Apartment Hotels

Altura Suites

Altura Suites

4 out of 5
Merced 562, departamento 1006A Santiago Region Metropolitana
Stay at this aparthotel in Santiago. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Costanera Center and Parque Arauco Mall are ...
Opens in a new windowAltura Suites
Sites Hotel

Sites Hotel

4 out of 5
Carrera 45 No. 5 - 15 Medellín
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $90 total per night from Apr 20 to Apr 21
$90 total
Apr 20 - Apr 21
Book a stay at this business-friendly aparthotel in Medellín. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
9.2/10 Wonderful! (1,138 reviews)
The location was pleasant and the rooms were a nice size.The breakfast was plentiful and the hotel staff was cheerful except for of a prickly male night receptionist. Alex, the reservations manager was extremely personable and informative.

Reviewed on Mar 12, 2026

Opens in a new windowSites Hotel
Hotel Du Parc

Hotel Du Parc

4.5 out of 5
Calle 9 Nº 41 - 36 Medellín Antioquia
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $156 total per night from Mar 25 to Mar 26
$156 total
Mar 25 - Mar 26
Book a stay at this luxury hotel in Medellín. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Great place!

Reviewed on Mar 20, 2026

Opens in a new windowHotel Du Parc
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Lancaster House

Lancaster House

4 out of 5
Paralela Autonorte No 106B - 28 Bogotá Distrito Capital
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Bogotá. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the overall value in ...
8.4/10 Very Good! (1,000 reviews)
Small gym, jacuzzi wasn’t available when I was there. Nice and respectful staff. Massage was booked at least 3 days ahead. Then I had to rebook it 2 days ahead and got confirmation via whats app that it was done. However, I waited and called the front desk and basically the message therapist came ...

Reviewed on Mar 17, 2026

Opens in a new windowLancaster House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic South America Accommodation Deals

Rochester Classic

Rochester Classic

3.5 out of 5
Esmeralda 542 Buenos Aires Capital Federal
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $75 total per night from Mar 24 to Mar 25
$75 total
Mar 24 - Mar 25
Book a stay at this business-friendly hotel in Buenos Aires. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Obelisco and Florida ...
7.8/10 Good! (413 reviews)
Mis padres estuvieron muy contentos con el servicio del hotel, el personal fue muy amable y colaborativo.

Reviewed on Nov 22, 2025

Opens in a new windowRochester Classic
Regal Pacific Buenos Aires

Regal Pacific Buenos Aires

4.5 out of 5
25 De Mayo, 764 Buenos Aires Capital Federal
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Buenos Aires. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,001 reviews)
This was our first stay in Argentina and everything was amazing. It would have been nice to have USB chargers in the room for cell phones. Still, the everyone was super nice and bilingual, as needed. Breakfast was very nice.

Reviewed on Mar 17, 2026

Opens in a new windowRegal Pacific Buenos Aires
Concorde Hotel

Concorde Hotel

3 out of 5
25 De Mayo 630 Buenos Aires Capital Federal
Stay at this hotel in Buenos Aires. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Florida Street and Plaza San Martin are located ...
6.6/10 (301 reviews)
Good located and no expensive hotel in Buenos Aire
Is an hotel located in micro center of Buenos Aires, near turístic atractives such us Casa Rosada and Puerto Madero, and near a subway station that permits get connected with all the city.

Reviewed on Mar 6, 2018

Opens in a new windowConcorde Hotel
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Almacruz Hotel y Centro de Convenciones

Almacruz Hotel y Centro de Convenciones

4 out of 5
San Antonio 65 Santiago Region Metropolitana
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $78 total per night from Mar 23 to Mar 24
$78 total
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Santiago. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (673 reviews)
Staff are friendly and professional. Just as the reviews all say, breakfast buffet is plentiful! We stayed clear of the eggs, but the fruit, pastries, and a la carte items were all fresh and delicious. Room was basic but clean, atmosphere in the common areas (lobby, etc) is like something from another ...

Reviewed on Mar 17, 2026

Opens in a new windowAlmacruz Hotel y Centro de Convenciones
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in South America

Hotel Las Americas Torre del Mar
Great for families

Hotel Las Americas Torre del Mar

4.5 out of 5
Anillo Vial, Sector Cielo Mar, Torre 2 Cartagena Bolivar
Fully refundableReserve now, pay when you stay
$224 nightly
The price is $224 total per night from Apr 18 to Apr 19
$224 total
Apr 18 - Apr 19
Book a stay at this luxury hotel in Cartagena. Enjoy free WiFi, free parking, and 5 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,001 reviews)

Families like: Outdoor pools, kids club, playground, miniature golf

Travelers say...
Hotel is old and need some improvements and renovations. For example, new linens and bedding. But the positive side is that it is in an excellent location and the staff is remarkably professional and nice.

Reviewed on Mar 16, 2026

Opens in a new windowHotel Las Americas Torre del Mar
Agora Suites Self-Service Boutique Hotel

Agora Suites Self-Service Boutique Hotel

3 out of 5
Calle 67B No. 60-67 Bogotá Bogota D.C.
Stay at this hotel in Bogotá. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Popular attractions Movistar Arena and Estadio Nemesio Camacho ...
9/10 Wonderful! (193 reviews)
Great property but be warned, no one after hours is there to greet you. After hours in my case was 7 pm. Though the next day, the maid was gone and no one there by 3 pm. Ideally you have communicated before on WhatsApp and have both the door code and the room code recorded. If not, assuming you have ...

Reviewed on Oct 29, 2024

Opens in a new windowAgora Suites Self-Service Boutique Hotel
Las Americas Casa de Playa
Great for families

Las Americas Casa de Playa

4 out of 5
Anillo Vial Sector Cielo Mar Cartagena Bolivar
Fully refundableReserve now, pay when you stay
$187 nightly
The price is $187 total per night from Apr 8 to Apr 9
$187 total
Apr 8 - Apr 9
Book a stay at this beach hotel in Cartagena. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (1,002 reviews)

Families like: Outdoor pools, waterslide, kids club, playground

Travelers say...
The entire property is well kept, rooms are clean and staff is very cordial.

Reviewed on Mar 20, 2026

Opens in a new windowLas Americas Casa de Playa
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Hilton Cartagena
Great for families

Hilton Cartagena

4.5 out of 5
Avenida Almirante Brion, El Laguito Cartagena
Fully refundableReserve now, pay when you stay
$206 nightly
The price is $206 total per night from Mar 29 to Mar 30
$206 total
Mar 29 - Mar 30
Book a stay at this luxury resort in Cartagena. Enjoy free parking, 4 outdoor pools, and a full-service spa. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,375 reviews)

Families like: Outdoor pools, waterslide, playground, close to beach

Travelers say...
No ocean view

Reviewed on Mar 19, 2026

Opens in a new windowHilton Cartagena
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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South America

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Mix and Match

At Orbitz, we turned a great idea from the world of fashion into another way for you to save money. When you shop our low cost tickets on flights to any destination, don’t be afraid to mix and match different airlines for maximum savings on your South America flights air ticket. Save more on air travel every day in every way at Orbitz.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.