Book 2 Star Hotels in Otay Mesa
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Featured Otay Mesa 2 Stars Hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Free Cancellation
1.96 mi from Otay Mesa
$118 nightly
The price is $134 total per night
$134 total
Aug 10 - Aug 11
Total includes taxes and fees
Guests staying at Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG enjoy an outdoor pool, a gym, and free WiFi in public areas. Free parking is included with your stay. The front desk is staffed 24/7 to help with luggage storage, tours or tickets, and securing valuables. Additional amenities include a business center, a meeting room, and express check-in.
Pool
Breakfast included

Hilton San Diego Bayfront
1 Park Blvd, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
14.72 mi from Otay Mesa
$218 nightly
The price is $253 total per night
$253 total
Sep 1 - Sep 2
Total includes taxes and fees
Hilton San Diego Bayfront features a full-service spa, an outdoor pool, and a children's pool. Parking is available for USD 55.00 per night (USD 75.00 per night for valet parking), and there's also limo/town car service. Multilingual staff at the 24-hour front desk can assist with dry cleaning/laundry, tours or tickets, and luggage storage. Other amenities at this spa hotel include a gym, a sauna, and free WiFi in public areas.
Pool
Hot Tub

Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
15.38 mi from Otay Mesa
$236 nightly
The price is $274 total per night
$274 total
Aug 31 - Sep 1
Total includes taxes and fees
Guests staying at Manchester Grand Hyatt San Diego enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is offered for USD 65 per night. Multilingual staff at the 24-hour front desk can assist with luggage storage, dry cleaning/laundry, and tours or tickets. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub

Embassy Suites by Hilton San Diego Bay Downtown
601 Pacific Hwy, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
15.54 mi from Otay Mesa
$202 nightly
The price is $234 total per night
$234 total
Aug 17 - Aug 18
Total includes taxes and fees
At Embassy Suites by Hilton San Diego Bay Downtown, guests enjoy an indoor pool, a gym, and WiFi in public areas. Valet parking is available for USD 65 per day, and there's also limo/town car service. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, concierge services, and dry cleaning/laundry. Other amenities at this family-friendly hotel include meeting rooms, conference space, and a business center.
Pool
Breakfast included

Dextro, Little Italy, BW Premier Collection
1617 1st Avenue, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
15.76 mi from Otay Mesa
$135 nightly
The price is $157 total per night
$157 total
Aug 10 - Aug 11
Total includes taxes and fees
Guests of Dextro, Little Italy, BW Premier Collection have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 35.00 per day. The front desk has multilingual staff standing by 24 hours a day to assist with luggage storage and tours/tickets. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Free WiFi

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
15.97 mi from Otay Mesa
$177 nightly
The price is $205 total per night
$205 total
Sep 1 - Sep 2
Total includes taxes and fees
Guests of Wyndham San Diego Bayside have access to an outdoor pool, a gym, and WiFi in public areas. Parking is USD 50.00 per night (USD 60 per night for valet parking)—but if you prefer not to drive, catch a ride in the free airport shuttle at scheduled times. Multilingual staff at the 24-hour front desk can assist with tours or tickets, dry cleaning/laundry, and securing valuables. Additional amenities include meeting rooms, a conference center, and a business center.
Pool
Free airport shuttle

Handlery Hotel
950 Hotel Cir N, San Diego, CA
18.06 mi from Otay Mesa
$111 nightly
The price is $128 total per night
$128 total
Sep 1 - Sep 2
Total includes taxes and fees
At Handlery Hotel, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. Self parking is available for USD 24 per night. The 24-hour front desk has multilingual staff ready to assist with concierge services, luggage storage, and dry cleaning/laundry. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub

The Dana on Mission Bay
1710 W Mission Bay Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
20.96 mi from Otay Mesa
$184 nightly
The price is $212 total per night
$212 total
Aug 17 - Aug 18
Total includes taxes and fees
Guests of The Dana on Mission Bay have access to a marina, 2 outdoor pools, and a gym. Self parking is available for USD 35 per night. The front desk has multilingual staff standing by 24 hours a day to assist with luggage storage and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include 2 hot tubs, free WiFi in public areas, and a conference center.
Pool
Hot Tub

Hyatt Regency Mission Bay Spa and Marina
1441 Quivira Rd, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
21.06 mi from Otay Mesa
$186 nightly
The price is $214 total per night
$214 total
Aug 18 - Aug 19
Total includes taxes and fees
Hyatt Regency Mission Bay Spa and Marina features a marina, a full-service spa, and 3 outdoor pools. Valet parking is offered for USD 55 per night. Multilingual staff at the 24-hour front desk can assist with concierge services, securing valuables, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this spa hotel include a gym, a sauna, and free WiFi in public areas.
Pool
Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa hotels essential information
Accommodation | 4,622 hotels |
---|---|
Lowest Price | $128 |
Highest Price | $274 |
Popular hotels | Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG, Wyndham San Diego Bayside, Manchester Grand Hyatt San Diego, The Dana on Mission Bay, Hyatt Regency Mission Bay Spa and Marina, Embassy Suites by Hilton San Diego Bay Downtown, Dextro, Little Italy, BW Premier Collection, Handlery Hotel, Hilton San Diego Bayfront |
Recent Reviews

Manchester Grand Hyatt San Diego
5/5 Excellent
"Beautiful hotel to stay staff pleasant and knowledgeable very clean lobby and in general entire hotel we enjoyed our stay"
A verified traveler from Redwood City stayed at Manchester Grand Hyatt San Diego
Posted 2 days ago