Hotels in Otay Mesa
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Featured Hotels in Otay Mesa

Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Free Cancellation
Reserve now, pay when you stay
14.9 mi from Otay Mesa
$248 nightly
The price is $287 total per night
$287 total
Apr 2 - Apr 3
Total with taxes and fees
Hard Rock Hotel San Diego features a nightclub, an outdoor pool, and a 24-hour gym. Valet parking is offered for USD 70 per night. Multilingual staff at the 24-hour front desk can assist with tours or tickets, dry cleaning/laundry, and securing valuables. Additional amenities include free WiFi in public areas, meeting rooms, and conference space.
Pool
Free WiFi

Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Free Cancellation
Reserve now, pay when you stay
15.38 mi from Otay Mesa
$346 nightly
The price is $401 total per night
$401 total
Apr 22 - Apr 23
Total with taxes and fees
Guests staying at Manchester Grand Hyatt San Diego enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is offered for USD 65 per night. Multilingual staff at the 24-hour front desk can assist with dry cleaning/laundry, concierge services, and securing valuables. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub

The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
Free Cancellation
15.76 mi from Otay Mesa
$135 nightly
The price is $157 total per night
$157 total
Apr 23 - Apr 24
Total with taxes and fees
Guests of The DEXTRO Little Italy, BW Premier Collection have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 35.00 per day. The front desk has multilingual staff standing by 24 hours a day to assist with tours/tickets and luggage storage. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Free WiFi

Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Free Cancellation
Reserve now, pay when you stay
15.97 mi from Otay Mesa
$182 nightly
The price is $211 total per night
$211 total
Apr 2 - Apr 3
Total with taxes and fees
Guests of Wyndham San Diego Bayside have access to an outdoor pool, a gym, and free WiFi in public areas. Self parking is offered for USD 50.00 per night. Multilingual staff at the 24-hour front desk can assist with luggage storage, dry cleaning/laundry, and concierge services. Additional amenities include meeting rooms, a conference center, and a business center.
Pool
Pet friendly

Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Free Cancellation
Reserve now, pay when you stay
17.44 mi from Otay Mesa
$163 nightly
The price is $188 total per night
$188 total
Apr 4 - Apr 5
Total with taxes and fees
Guests of Sheraton San Diego Resort have access to a marina, 3 outdoor pools, and a 24-hour gym. Parking is USD 55 per night (USD 67 per night for valet parking)—but if you prefer not to drive, catch a ride in the free airport shuttle during limited hours. Multilingual staff at the 24-hour front desk can assist with luggage storage, dry cleaning/laundry, and concierge services. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include 2 hot tubs, free WiFi in public areas, and a conference center.
Pool
Hot Tub

Best Western Seven Seas
411 Hotel Circle South San Diego CA
Free Cancellation
Reserve now, pay when you stay
17.84 mi from Otay Mesa
$82 nightly
The price is $94 total per night
$94 total
Apr 2 - Apr 3
Total with taxes and fees
Guests of Best Western Seven Seas have access to an outdoor pool, a gym, and 2 hot tubs. Free parking is included with your stay. The front desk has multilingual staff on hand 24/7 to help with luggage storage, tours or tickets, and securing valuables. Additional amenities include free WiFi in public areas, conference space, and a business center.
Pool
Hot Tub

Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
Free Cancellation
Reserve now, pay when you stay
17.89 mi from Otay Mesa
$107 nightly
The price is $123 total per night
$123 total
Apr 26 - Apr 27
Total with taxes and fees
At Days Inn by Wyndham San Diego Hotel Circle, guests enjoy an outdoor pool, a gym, and free WiFi in public areas. Self parking is available for USD 20 per day. The front desk has multilingual staff on hand 24/7 to help with luggage storage, securing valuables, and concierge services. Additional amenities include a hot tub, conference space, and a business center.
Pool
Hot Tub

Handlery Hotel
950 Hotel Cir N San Diego CA
Free Cancellation
Reserve now, pay when you stay
18.06 mi from Otay Mesa
$129 nightly
The price is $148 total per night
$148 total
Apr 13 - Apr 14
Total with taxes and fees
At Handlery Hotel, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. Self parking is available for USD 24 per night. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry, luggage storage, and concierge services. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub

Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Free Cancellation
Reserve now, pay when you stay
21.45 mi from Otay Mesa
$288 nightly
The price is $331 total per night
$331 total
Apr 26 - Apr 27
Total with taxes and fees
Paradise Point Resort & Spa features a marina, a full-service spa, and 5 outdoor pools. Self parking is available for USD 49 per night. The front desk has multilingual staff on hand 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Other amenities at this beach resort include a gym, 5 hot tubs, and a sauna.
Pool
Hot Tub
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa hotels essential information
Accommodation | 4,883 hotels |
|---|---|
Lowest Price | $94 |
Highest Price | $401 |
Popular hotels | Paradise Point Resort & Spa, Best Western Seven Seas, Hard Rock Hotel San Diego, Handlery Hotel, The DEXTRO Little Italy, BW Premier Collection, Days Inn by Wyndham San Diego Hotel Circle, Manchester Grand Hyatt San Diego, Wyndham San Diego Bayside, Sheraton San Diego Resort |
Popular places to visit

San Diego Zoo
4.5/5(3,631 reviews)
Why not visit the animals who live at San Diego Zoo and see why this is a favorite attraction in San Diego? Stroll along the area's seaside or experience its acclaimed theater scene.

San Diego Convention Center
4.5/5(1,324 reviews)
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.

Mission Bay
4.5/5(2,416 reviews)
Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.
Recent Reviews

Hard Rock Hotel San Diego
5/5 Excellent
"Wonderful stay and friendly staff. We needed to
Leave early (11 pm 3/27) and the staff was understanding "
A verified traveler stayed at Hard Rock Hotel San Diego
Posted 2 hours ago
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