Compare Depew Motels

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Featured Depew Motels

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Depew 2 Star Accommodation

    Hampton Inn Buffalo - Amherst, NY

    Hampton Inn Buffalo - Amherst, NY

    1601 Amherst Manor Drive Buffalo NY
    $106 nightly
    The price is $120 total per night from Jan 5 to Jan 6
    $120 total
    Jan 5 - Jan 6, 2026
    Total with taxes and fees
    9.2/10 Wonderful! (1,995 reviews)
    Sleep Inn & Suites Buffalo Airport

    Sleep Inn & Suites Buffalo Airport

    100 Holtz Dr Buffalo NY
    $84 nightly
    The price is $96 total per night from Jan 19 to Jan 20
    $96 total
    Jan 19 - Jan 20, 2026
    Total with taxes and fees
    7.8/10 Good! (1,909 reviews)
    CenterWay Hotel Tonawanda

    CenterWay Hotel Tonawanda

    225 Crestmount Avenue Tonawanda NY
    $60 nightly
    The price is $68 total per night from Dec 30 to Dec 31
    $68 total
    Dec 30 - Dec 31
    Total with taxes and fees
    7.8/10 Good! (1,001 reviews)

Pet Friendly Motels in Depew

    Buffalo Airport Hotel

    Buffalo Airport Hotel

    4600 Genesee St Buffalo NY
    $94 nightly
    The price is $107 total per night from Jan 11 to Jan 12
    $107 total
    Jan 11 - Jan 12, 2026
    Total with taxes and fees
    7.8/10 Good! (2,794 reviews)
    M Hotel Buffalo

    M Hotel Buffalo

    2040 Walden Ave Buffalo NY
    $99 nightly
    The price is $113 total per night from Dec 30 to Dec 31
    $113 total
    Dec 30 - Dec 31
    Total with taxes and fees
    7.2/10 Good! (2,552 reviews)
    Hyatt Regency Buffalo / Hotel and Conference Center

    Hyatt Regency Buffalo / Hotel and Conference Center

    Two Fountain Plaza Buffalo NY
    $143 nightly
    The price is $167 total per night from Jan 12 to Jan 13
    $167 total
    Jan 12 - Jan 13, 2026
    Total with taxes and fees
    8/10 Very Good! (1,689 reviews)

Motels

Book a motel in Depew
Simple and cost-effective, motels are a great choice for the budget traveler. If all you need is four walls, a roof and a comfy bed for the night, motels are for you. You’ll be spending all your time enjoying the sights and sounds of Depew, anyway.

Cheap motels can help you preserve your limited travel funds so you can spend more on good eats, great concerts or fascinating adventures around Depew. There’s no reason to spend more on a boutique hotel if you’ll be spending the majority of your time out on the town! Orbitz has a great selection of motels in Depew, so start browsing and planning your getaway.

Budget motels make travel a breeze
Cheap motels can make it possible for you to visit Depew and see everything it has to offer. They’re good for business travelers, too—budget motels help protect your bottom line. If you live in Depew and need somewhere local or “near me” to stay during a home renovation or between moves, a motel is a great option as a short-term solution. You can find motel accommodations near major Depew landmarks and off the beaten path.

Not every motel is the same, though. Some provide just the basics, while others offer swimming pools, gyms, cable TV, free Wi-Fi and other services. Extended stay motel rooms usually include a kitchenette and small fridge, which allows you to save even more money by cooking and storing your own food instead of eating out every night.

Is your furry friend coming with you on your trip to Depew? Search through Orbitz’s listings of pet-friendly motels in Depew to make sure your best friend has a place to stay as well.

Depew Motels essential information

Accommodation
40 Motels
Lowest Price
$63
Highest Price
$167
Popular accommodation
Motel 6 Amherst, NY - Buffalo, Motel 6 Buffalo, NY - Airport - Williamsville, Motel 6 Hamburg, NY, Red Carpet Inn Orchard Park - Buffalo, NY, Budget Inn, Scottish Inns Kenmore, Travelodge by Wyndham Niagara Falls, Sands Motel Niagara Falls, Super 8 by Wyndham Niagara Falls NY

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