Book 5 Star Hotels in Lake Nona Medical City

Name: Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Price range: $112 total

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Sep 29 - Sep 30

Tonight

Sep 30 - Oct 1

Tomorrow night

Featured Lake Nona Medical City 5 Stars Hotels

Hyatt Regency Orlando International Airport

Free Cancellation

Reserve now, pay when you stay

4.77 mi from Lake Nona Medical City

$199 nightly

$224 total

Oct 1 - Oct 2

Total with taxes and fees

At Hyatt Regency Orlando International Airport, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. Parking is available for USD 19 per night (USD 25 per night for valet parking), and there's also limo/town car service. Multilingual staff at the 24-hour front desk can assist with luggage storage, securing valuables, and tours or tickets. Additional amenities include conference space, a 24-hour business center, and a computer station.

Free Cancellation

Reserve now, pay when you stay

6.98 mi from Lake Nona Medical City

$97 nightly

$109 total

Oct 6 - Oct 7

Total with taxes and fees

At DoubleTree by Hilton Orlando Airport, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Parking is USD 22.00 per day (USD 30 per day for valet parking)—but if you prefer not to drive, catch a ride in the free airport shuttle during limited hours. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, concierge services, and luggage storage. Additional amenities include a conference center, a 24-hour business center, and coffee/tea in a common area.

Free Cancellation

Reserve now, pay when you stay

11.11 mi from Lake Nona Medical City

$87 nightly

$98 total

Oct 26 - Oct 27

Total with taxes and fees

Marriott's Grande Vista features a golf course, a full-service spa, and 4 outdoor pools. Self parking is offered for USD 25 per night. Front-desk staff can answer questions 24/7, and assist with concierge services, dry cleaning/laundry, and luggage storage. Other amenities at this spa hotel include a children's pool, a 24-hour gym, and 4 hot tubs.

DoubleTree by Hilton Hotel Orlando at SeaWorld

Free Cancellation

Reserve now, pay when you stay

11.77 mi from Lake Nona Medical City

$92 nightly

$104 total

Oct 9 - Oct 10

Total with taxes and fees

Guests of DoubleTree by Hilton Hotel Orlando at SeaWorld enjoy 2 outdoor pools, a children's pool, and a 24-hour gym. Self parking is offered for USD 38 per night. The 24-hour front desk has multilingual staff ready to assist with luggage storage, concierge services, and dry cleaning/laundry. Other amenities at this family-friendly resort include free WiFi in public areas, meeting rooms, and conference space.

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Free Cancellation

Reserve now, pay when you stay

12.39 mi from Lake Nona Medical City

$96 nightly

$108 total

Oct 19 - Oct 20

Total with taxes and fees

Guests of Sheraton Vistana Villages Resort Villas, I-Drive/Orlando enjoy 5 outdoor pools, a children's pool, and a 24-hour gym. If you drive, self parking is USD 25.00 per night, and there's also a theme park shuttle. Multilingual staff at the 24-hour front desk can assist with dry cleaning/laundry, tours or tickets, and access to locker space. Other amenities at this family-friendly hotel include 4 hot tubs, a sauna, and outdoor tennis courts.

Westgate Lakes Resort & Spa Universal Studios Area

Free Cancellation

Reserve now, pay when you stay

12.88 mi from Lake Nona Medical City

$120 nightly

$135 total

Sep 30 - Oct 1

Total with taxes and fees

Westgate Lakes Resort & Spa Universal Studios Area features a marina, a full-service spa, and 7 outdoor pools. Free valet and self parking are available, and there's also a free theme park shuttle. Multilingual staff at the front desk are standing by 24/7 to help with tours or tickets, luggage storage, and securing valuables. Other amenities at this spa hotel include a water park, a lazy river, and a children's pool.

DoubleTree by Hilton at the Entrance to Universal Orlando

Free Cancellation

Reserve now, pay when you stay

13.46 mi from Lake Nona Medical City

$101 nightly

$114 total

Oct 12 - Oct 13

Total with taxes and fees

DoubleTree by Hilton at the Entrance to Universal Orlando features an outdoor pool, a children's pool, and a 24-hour gym. Valet parking is available for USD 41.00 per night. Multilingual staff at the 24-hour front desk can assist with tours or tickets, dry cleaning/laundry, and luggage storage. Other amenities at this family-friendly hotel include free WiFi in public areas, a hot tub, and meeting rooms.

Free Cancellation

Reserve now, pay when you stay

13.81 mi from Lake Nona Medical City

$133 nightly

$150 total

Sep 30 - Oct 1

Total with taxes and fees

At Universal's Cabana Bay Beach Resort, guests enjoy 2 outdoor pools, a lazy river, and a gym. If you drive, self parking is USD 26 per night, and there's also a free theme park shuttle. Multilingual staff at the front desk are standing by 24/7 to help with dry cleaning/laundry, luggage storage, and securing valuables. Other amenities at this family-friendly hotel include 2 hot tubs, free WiFi in public areas, and an arcade/game room.

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Free Cancellation

Reserve now, pay when you stay

13.99 mi from Lake Nona Medical City

$99 nightly

$112 total

Oct 27 - Oct 28

Total with taxes and fees

Guests of Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando enjoy 6 outdoor pools, a children's pool, and a gym. Self parking is offered for USD 25.00 per night. The 24-hour front desk has multilingual staff ready to assist with luggage storage, securing valuables, and concierge services. Other amenities at this family-friendly hotel include 8 hot tubs, a sauna, and outdoor tennis courts.

Don't see what you're looking for?

See all available properties in Lake Nona Medical City

View all properties

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best 5 star hotels in Lake Nona Medical City

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in Lake Nona Medical City. After all, treating yourself to the finer things is what vacations are about.

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These Lake Nona Medical City hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
Lake Nona Medical City 5 star hotels and resorts typically offer luxury amenities such as:

Gourmet restaurant
Full-service fitness center with pool
Luxury spa
Welcome gifts upon arrival
Top-of-the-line beds and linens
Designer personal care products
Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in Lake Nona Medical City with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place:

Search hotels by price, ranging from $98 to $224
Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
Choose from 27,628 5 star hotels in Lake Nona Medical City!

Lake Nona Medical City hotels essential information

Accommodation	27,628 hotels
Lowest Price	$98
Highest Price	$224
Popular hotels	Marriott's Grande Vista, Hyatt Regency Orlando International Airport, Universal's Cabana Bay Beach Resort, DoubleTree by Hilton at the Entrance to Universal Orlando, Sheraton Vistana Villages Resort Villas, I-Drive/Orlando, DoubleTree by Hilton Hotel Orlando at SeaWorld, Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando, DoubleTree by Hilton Orlando Airport, Westgate Lakes Resort & Spa Universal Studios Area

Recent Reviews

5/5 Excellent

"My partner and I have been staying at Cabana Bay every year for the past 5 years. As usual, the rooms were clean, the staff was great ( especially Kharia at the front desk), and it was really convenient for all of our theme park days."

A verified traveler stayed at Universal's Cabana Bay Beach Resort

Posted 5 hours ago

More to Explore

Va Medical Center at Lake Nona