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Featured Lake Nona Medical City 5 Stars Hotels

Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

4 out of 5
9300 Jeff Fuqua Boulevard Orlando FL
Free Cancellation
Reserve now, pay when you stay
4.77 mi from Lake Nona Medical City
$199 nightly
The price is $224 total per night
$224 total
Apr 7 - Apr 8
Total with taxes and fees
At Hyatt Regency Orlando International Airport, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. Parking is available for USD 19 per night (USD 25 per night for valet parking), and there's also limo/town car service. Multilingual staff at the 24-hour front desk can assist with dry cleaning/laundry, tours or tickets, and securing valuables. Other amenities at this family-friendly hotel include conference space, a 24-hour business center, and a computer station.
Marriott's Grande Vista

Marriott's Grande Vista

4 out of 5
5925 Avenida Vista Orlando FL
Free Cancellation
Reserve now, pay when you stay
11.11 mi from Lake Nona Medical City
$139 nightly
The price is $156 total per night
$156 total
Apr 11 - Apr 12
Total with taxes and fees
Marriott's Grande Vista features a golf course, a full-service spa, and 4 outdoor pools. Self parking is offered for USD 31.95 per night. Front-desk staff can answer questions 24/7, and assist with concierge services, luggage storage, and dry cleaning/laundry. Other amenities at this spa condominium resort include a children's pool, a 24-hour gym, and 4 hot tubs.
Rosen Inn at Pointe Orlando

Rosen Inn at Pointe Orlando

3 out of 5
9000 International Drive Orlando FL
Free Cancellation
Reserve now, pay when you stay
12.86 mi from Lake Nona Medical City
$89 nightly
The price is $100 total per night
$100 total
Apr 28 - Apr 29
Total with taxes and fees
Guests staying at Rosen Inn at Pointe Orlando enjoy access to 3 outdoor pools, a gym, and free WiFi in public areas. If you drive, self parking is USD 10 per night, and there's also limo/town car service. Multilingual staff at the 24-hour front desk can assist with securing valuables, tours or tickets, and dry cleaning/laundry. Other amenities at this family-friendly hotel include meeting rooms, a 24-hour business center, and a computer station.
Pool
Pet friendly
Westgate Lakes Resort & Spa Universal Studios Area

Westgate Lakes Resort & Spa Universal Studios Area

4 out of 5
9500 Turkey Lake Rd Orlando FL
12.88 mi from Lake Nona Medical City
$127 nightly
The price is $143 total per night
$143 total
Apr 26 - Apr 27
Total with taxes and fees
Westgate Lakes Resort & Spa Universal Studios Area features a marina, a full-service spa, and 7 outdoor pools. Free valet and self parking are available, and there's also a free theme park shuttle. Multilingual staff at the front desk are standing by 24/7 to help with luggage storage, dry cleaning/laundry, and concierge services. Other amenities at this spa hotel include a water park, a lazy river, and a children's pool.
Universal's Cabana Bay Beach Resort

Universal's Cabana Bay Beach Resort

3.5 out of 5
6550 Adventure Way Orlando FL
Free Cancellation
Reserve now, pay when you stay
13.81 mi from Lake Nona Medical City
$133 nightly
The price is $150 total per night
$150 total
Apr 5 - Apr 6
Total with taxes and fees
At Universal's Cabana Bay Beach Resort, guests enjoy 2 outdoor pools, a lazy river, and a gym. If you drive, self parking is USD 26 per night, and there's also a free theme park shuttle. Multilingual staff at the front desk are standing by 24/7 to help with tours or tickets, luggage storage, and dry cleaning/laundry. Other amenities at this family-friendly hotel include 2 hot tubs, free WiFi in public areas, and an arcade/game room.
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr Orlando FL
Free Cancellation
Reserve now, pay when you stay
13.99 mi from Lake Nona Medical City
$128 nightly
The price is $144 total per night
$144 total
Apr 26 - Apr 27
Total with taxes and fees
Guests of Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando enjoy 6 outdoor pools, a children's pool, and a gym. Self parking is offered for USD 31.95 per night. The 24-hour front desk has multilingual staff ready to assist with securing valuables, luggage storage, and concierge services. Other amenities at this family-friendly aparthotel include 8 hot tubs, a sauna, and outdoor tennis courts.
Holiday Inn Resort Orlando Suites - Waterpark by IHG

Holiday Inn Resort Orlando Suites - Waterpark by IHG

3.5 out of 5
18000 International Dr S. Orlando FL
Free Cancellation
14.22 mi from Lake Nona Medical City
$116 nightly
The price is $131 total per night
$131 total
Apr 12 - Apr 13
Total with taxes and fees
Guests of Holiday Inn Resort Orlando Suites - Waterpark by IHG have access to 2 outdoor pools, a free water park, and a gym. Self parking is offered for USD 31 per night. The front desk has multilingual staff on hand 24/7 to help with concierge services, access to locker space, and securing valuables. Other amenities at this family-friendly hotel include 2 hot tubs, free WiFi in public areas, and conference space.
Vacation Village Orlando, Celebration

Vacation Village Orlando, Celebration

3 out of 5
2975 Arabian Nights Blvd Kissimmee FL
Free Cancellation
Reserve now, pay when you stay
15.76 mi from Lake Nona Medical City
$117 nightly
The price is $133 total per night
$133 total
Apr 26 - Apr 27
Total with taxes and fees
Guests of Vacation Village Orlando, Celebration enjoy 7 outdoor pools, a children's pool, and a gym. You can take advantage of onsite parking for a fee, along with an area shuttle. The 24-hour front desk has staff standing by to help with tours/tickets and luggage storage. Other amenities at this family-friendly condo building include 7 hot tubs, free WiFi in public areas, and a business center.
Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

3 out of 5
7491 W Irlo Bronson Memorial Hwy Kissimmee FL
Free Cancellation
Reserve now, pay when you stay
19.12 mi from Lake Nona Medical City
$134 nightly
The price is $153 total per night
$153 total
Apr 12 - Apr 13
Total with taxes and fees
Guests staying at Kompose Boutique Resort at Theme Parks enjoy an outdoor pool, a 24-hour gym, and 2 hot tubs. Self parking is available for USD 14.99 per night. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a sauna, free WiFi in public areas, and a computer station.
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Best 5 star hotels in Lake Nona Medical City

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in Lake Nona Medical City. After all, treating yourself to the finer things is what vacations are about. 

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These Lake Nona Medical City hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
Lake Nona Medical City 5 star hotels and resorts typically offer luxury amenities such as:

  • Gourmet restaurant
  • Full-service fitness center with pool
  • Luxury spa 
  • Welcome gifts upon arrival
  • Top-of-the-line beds and linens 
  • Designer personal care products
  • Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in Lake Nona Medical City with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place: 

  • Search hotels by price, ranging from $100 to $224
  • Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
  • Choose from 27,604 5 star hotels in Lake Nona Medical City!

Lake Nona Medical City hotels essential information

Accommodation
27,604 hotels
Lowest Price
$100
Highest Price
$224
Popular hotels
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando, Universal's Cabana Bay Beach Resort, Hyatt Regency Orlando International Airport, Kompose Boutique Resort at Theme Parks, Westgate Lakes Resort & Spa Universal Studios Area, Rosen Inn at Pointe Orlando, Marriott's Grande Vista, Vacation Village Orlando, Celebration, Holiday Inn Resort Orlando Suites - Waterpark by IHG

Recent Reviews

Kompose Boutique Resort at Theme Parks

Kompose Boutique Resort at Theme Parks

3/5 Okay
"Clean room bethrar"
A verified traveler stayed at Kompose Boutique Resort at Theme Parks
Posted 2 hours ago
Kompose Boutique Resort at Theme Parks

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