Cheap flights from DEN to FLO (Denver Intl. to Florence Regional)

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Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence, Florence, SC
$107 nightly
The price is $120 total per night from Aug 14 to Aug 15
$120 total
Aug 14 - Aug 15
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,003 reviews)
"Solid place for an overnight stay"

Reviewed on Jul 31, 2025

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St, Florence, SC
$124 nightly
The price is $139 total per night from Aug 10 to Aug 11
$139 total
Aug 10 - Aug 11
Total includes taxes and fees
Stay at this 3-star spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (577 reviews)
"Loved the staircase"

Reviewed on Jul 26, 2025

Hotel Florence, Tapestry Collection by Hilton
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Florence
Stay at this vacation home in Florence. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Old Greenwood Athletic Park and Greenwood Baseball ...
9.6/10 Exceptional! (5 reviews)
House
"The neighborhood was good. House was very clean and , way better in person than the"

Reviewed on Apr 23, 2025

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Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Comfort Inn & Suites

Comfort Inn & Suites

2.5 out of 5
527 Woody Jones Blvd, Florence, SC
$108 nightly
The price is $121 total per night from Aug 24 to Aug 25
$121 total
Aug 24 - Aug 25
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,046 reviews)
"Good location off I 95 for a weary traveler, clean & with friendly & accomodating staff"

Reviewed on Aug 1, 2025

Comfort Inn & Suites
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
$84 nightly
The price is $94 total per night from Sep 1 to Sep 2
$94 total
Sep 1 - Sep 2
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,102 reviews)
"Good hotel poor surpunding"

Reviewed on Jul 31, 2025

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
$70 nightly
The price is $79 total per night from Aug 3 to Aug 4
$79 total
Aug 3 - Aug 4
Total includes taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,317 reviews)
Awesome
"I stay here for work related trips.Always a good affordable place to stay very clean and quiet with plenty of restaurants and stores to accommodate your stay"

Reviewed on Jul 30, 2025

Howard Johnson by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard, Florence, SC
$56 nightly
The price is $63 total per night from Aug 6 to Aug 7
$63 total
Aug 6 - Aug 7
Total includes taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,001 reviews)
"For someone on the road looking to just rest Night person was pre-occupied with other things than reservations and not very polite with the incidental protocol. Morning crew friendly"

Reviewed on Jul 30, 2025

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway, Timmonsville, SC
$54 nightly
The price is $60 total per night from Sep 1 to Sep 2
$60 total
Sep 1 - Sep 2
Total includes taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (311 reviews)
"Was perfect for a middle of the night stop due to pouring rain."

Reviewed on Jul 20, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr, Florence, SC
$63 nightly
The price is $70 total per night from Sep 2 to Sep 3
$70 total
Sep 2 - Sep 3
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,002 reviews)
"I would reserve again, but my wife has her own opinion."

Reviewed on Jul 20, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd, Florence, SC
$110 nightly
The price is $123 total per night from Aug 24 to Aug 25
$123 total
Aug 24 - Aug 25
Total includes taxes and fees
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,001 reviews)
Nice stay!
"Nice, clean, comfortable, convenient and staff was friendly. Breakfast was ok. Wish they had scrambled eggs and bacon."

Reviewed on Jul 15, 2025

Home2 Suites by Hilton Florence, SC
Baymont Inn & Suites Florence by Wyndham

Baymont Inn & Suites Florence by Wyndham

2.5 out of 5
1826 W Lucas Street, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Dr. Eddie Floyd Tennis Center ...
"Still in Renovation mode"

Reviewed on Sep 3, 2024

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Baymont Inn & Suites Florence by Wyndham
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd, Florence, SC
$105 nightly
The price is $117 total per night from Aug 5 to Aug 6
$117 total
Aug 5 - Aug 6
Total includes taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (2 reviews)
Lack of hot breakfast
"Very disappointed in the lack of hot breakfast. The breakfast was one of the reasons I booked with Country Inn and Suites. If I had known it had changed and would not have the breakfast I would have changed hotels."

Reviewed on Jul 28, 2025

Spark by Hilton Florence North I-95, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

DEN to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from Denver Airport to FLO?
From Denver, the exciting sights and sounds of Florence are 3 hours and 57 minutes away. Book your favorite seat, or perhaps even upgrade to one with extra legroom, and travel to your destination in total comfort.
How many hours flight from DIA airport to Florence Regional Airport?
Settle in and get comfortable, because the average flight time from DIA airport to Florence Regional Airport (FLO) is 4 hours and 17 minutes. Watch a few movies, put your nose in a book ... You'll have ample time to kick back and enjoy the ride.
What airlines have the most flights from Denver Airport to FLO?
There are no airlines that fly direct between DEN and Florence Regional Airport. Be organized and secure a multi-stop or one-stop plane ticket.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.