$131 Cheap flight deals from Mexico City (MEX) to Panama City (PTY)

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This Weekend's Flight Deals from Mexico City to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Mar 27 - Tue, Mar 31
MEX
Mexico City Intl.
PTY
Tocumen Intl.
$569 Roundtrip, found 1 day ago
$569
Roundtrip
found 1 day ago
Select avianca flight, departing Fri, Mar 27 from Mexico City Intl. to Tocumen Intl., returning Tue, Mar 31, priced at $569 found 1 day ago

Airfares from $131 One Way, $311 Round Trip from Mexico City to Panama City

Prices starting at $311 for return flights and $131 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, May 4 - Sat, May 9
MEX
Mexico City
PTY
Panama City
$311 Roundtrip, found 1 day ago
$311
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, May 4 from Mexico City to Panama City, returning Sat, May 9, priced at $311 found 1 day ago
Thu, May 14 - Thu, May 21
MEX
Mexico City
PTY
Panama City
$334 Roundtrip, found 2 days ago
$334
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, May 14 from Mexico City to Panama City, returning Thu, May 21, priced at $334 found 2 days ago
Thu, May 14 - Thu, May 21
MEX
Mexico City
PTY
Panama City
$360 Roundtrip, found 2 days ago
$360
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, May 14 from Mexico City to Panama City, returning Thu, May 21, priced at $360 found 2 days ago
Thu, May 21 - Fri, May 22
MEX
Mexico City
PTY
Panama City
$361 Roundtrip, found 2 days ago
$361
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, May 21 from Mexico City to Panama City, returning Fri, May 22, priced at $361 found 2 days ago
Thu, Apr 16 - Thu, Apr 23
MEX
Mexico City
PTY
Panama City
$374 Roundtrip, found 5 days ago
$374
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Thu, Apr 16 from Mexico City to Panama City, returning Thu, Apr 23, priced at $374 found 5 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
5.0-star property

Hotel Riu Plaza Panama

9/10 Wonderful! (5,100 reviews)

Apr 22 - Apr 27

5 night stay

Mexico City (MEX) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $994, price is now $654 per person
$654
per person
just found
pool area and breakfast buffet were awesome. Hotel is about 20 min from the airport. The Ciysightseeingbus is near by.

Reviewed on Jan 16, 2026

Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9/10 Wonderful! (1,000 reviews)

Apr 22 - Apr 27

5 night stay

Mexico City (MEX) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,526, price is now $941 per person
$941
per person
just found
Kimberly at the Front Desk was wonderful!

Reviewed on Jun 8, 2025

W Panama
5.0-star property

W Panama

9/10 Wonderful! (1,019 reviews)

Apr 22 - Apr 27

5 night stay

Mexico City (MEX) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,184, price is now $866 per person
$866
per person
just found
Had a great time, room service was great as well

Reviewed on Feb 28, 2026

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More About Flying To Panama City from Mexico City

Route Information for Flights from Mexico City to Panama City

Origin Airport IATA Code
MEX
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Mexico City to Panama City

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Unbeatable Deals for Flights From Mexico City to Panama City

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Book Cheap Mexico City to Panama City Flights Anytime

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Don't Miss Out on Frequent Flyer Points

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Easy Flight Cancellation

In most cases, you can cancel flights from Mexico City to Panama City online with the same ease as you booked them.

Frequently asked questions

Are there non-stop flights from Mexico City to Panama City?
There is. You can fly directly from Mexico City to Panama City with Copa Airlines. It's the only airline that travels nonstop from Mexico City, Distrito Federal (MEX-Mexico City Intl.) to Tocumen Intl. Airport (PTY).
What is the shortest flight from Mexico City to Panama City?
From Mexico City, the wonderful sights and sounds of Panama City are at least 3 hours and 33 minutes away. Book your favorite seat, or perhaps even one with extra legroom, and travel to your destination in comfort.
What airlines fly from Mexico City to Panama City most frequently?
Organize your Mexico City to Panama City trip with a Copa Airlines flight. With 152 each month, this airline has the most flights along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.