$177 Cheap flight deals from Mexico City (MEX) to Panama City (PTY)

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This Weekend's Flight Deals from Mexico City to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, May 23 - Sat, May 24
MEX
Mexico City Intl.
PTY
Tocumen Intl.
$372 Roundtrip, found 20 hours ago
$372
Roundtrip
found 20 hours ago
Select avianca flight, departing Fri, May 23 from Mexico City Intl. to Tocumen Intl., returning Sat, May 24, priced at $372 found 20 hours ago

Airfares from $177 One Way, $352 Round Trip from Mexico City to Panama City

Prices starting at $352 for return flights and $177 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Jun 12 - Mon, Jun 23
MEX
Mexico City
PTY
Panama City
$352 Roundtrip, found 5 hours ago
$352
Roundtrip
found 5 hours ago
Select Aeromexico flight, departing Thu, Jun 12 from Mexico City to Panama City, returning Mon, Jun 23, priced at $352 found 5 hours ago
Sun, Jul 13 - Sun, Jul 20
MEX
Mexico City
PTY
Panama City
$355 Roundtrip, found 3 days ago
$355
Roundtrip
found 3 days ago
Select Aeromexico flight, departing Sun, Jul 13 from Mexico City to Panama City, returning Sun, Jul 20, priced at $355 found 3 days ago
Thu, Jul 17 - Fri, Aug 1
MEX
Mexico City
PTY
Panama City
$357 Roundtrip, found 5 hours ago
$357
Roundtrip
found 5 hours ago
Select Aeromexico flight, departing Thu, Jul 17 from Mexico City to Panama City, returning Fri, Aug 1, priced at $357 found 5 hours ago
Mon, Jun 2 - Fri, Jun 6
MEX
Mexico City
PTY
Panama City
$372 Roundtrip, just found
$372
Roundtrip
just found
Select avianca flight, departing Mon, Jun 2 from Mexico City to Panama City, returning Fri, Jun 6, priced at $372 just found
Sun, May 25 - Wed, May 28
MEX
Mexico City
PTY
Panama City
$408 Roundtrip, found 15 hours ago
$408
Roundtrip
found 15 hours ago
Select Copa flight, departing Sun, May 25 from Mexico City to Panama City, returning Wed, May 28, priced at $408 found 15 hours ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
5.0-star property

Hotel Riu Plaza Panama

9/10 Wonderful! (3,763 reviews)

Jun 16 - Jun 20

4 night stay

Mexico City (MEX) to Panama City (PTY)

Aeromexico • Roundtrip • Coach
per person
found 1 day ago
The location is very central. The staff is not proactive and trusted to make decision without checking with a manager. Empower your employees especially the ones with tenure and experience. There has to be a better way of allowing people with e-cedula cards to get the discount for hotel stays. Going through RIU International reservation does not work. It is as if it e-cedula not accepted by RIU.

Reviewed on May 10, 2025

Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9/10 Wonderful! (863 reviews)

Jun 16 - Jun 20

4 night stay

Mexico City (MEX) to Panama City (PTY)

Aeromexico • Roundtrip • Coach
Save 100% on your flight
per person
found 1 day ago
The cleanliness, hospitality and variety of restaurants

Reviewed on Apr 13, 2024

Bristol Panama, a Registry Collection Hotel
5.0-star property

Bristol Panama, a Registry Collection Hotel

9.2/10 Wonderful! (1,003 reviews)

Jun 16 - Jun 20

4 night stay

Mexico City (MEX) to Panama City (PTY)

Aeromexico • Roundtrip • Coach
per person
found 1 day ago
The Bristol is my home in Panamá.

Reviewed on Jul 5, 2023

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More About Flying To Panama City from Mexico City

Route Information for Flights from Mexico City to Panama City

Origin Airport IATA Code
MEX
Destination Airport IATA Code
PTY
Distance
1498 mi
Direct Flight Airlines
Emirates, Copa Airlines
Earliest Flight Arrival
11:18AM UTC
Latest Flight Arrival
1:13AM UTC

Mexico City to Panama City

If you feel you cannot afford the costs involved to your dream trip to a local or international destination happen, think again! Orbitz gives you incredible deals on flights from Mexico City to Panama City. Now you can book guaranteed low fares for Mexico City to Panama City flights and plan your trip with confidence.

Great deals on flights from Mexico City to Panama City

Cheap airfares on Mexico City to Panama City flights allow you to stick to your budget and still have a great trip. We give you guaranteed low prices and make it easy to research and book discount flights using our website. Additionally, you can add your frequent flyer numbers to your Orbitz account profile, and this information will automatically be included on all your future reservations for qualified flights from Mexico City to Panama City.

Cutting-edge mobile tools make travel easy

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Mexico City to Panama City flights at discounted rates

Finding flights at the right prices can be difficult if you are not sure where to look. Don’t ruin your trip by spending more on your flights than your budget allows. Orbitz gives you guaranteed low fares on Mexico City to Panama City flights and amazing discount offers on car rentals, hotels, and even fun activities in your destination. Your dream trip is more affordable than ever with Orbitz.

Frequently asked questions

Are there non-stop flights from Mexico City to Panama City?
There is. You can fly directly from Mexico City to Panama City with Copa Airlines. It’s the only airline that travels nonstop from Mexico City, Distrito Federal (MEX-Mexico City Intl.) to Tocumen Intl. Airport (PTY).
What is the shortest flight from Mexico City to Panama City?
From Mexico City, the wonderful sights and sounds of Panama City are at least 3 hours and 33 minutes away. Book your favorite seat, or perhaps even one with extra legroom, and travel to your destination in comfort.
What airlines fly from Mexico City to Panama City most frequently?
Organize your Mexico City to Panama City trip with a Copa Airlines flight. With 152 each month, this airline has the most flights along this route.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won’t keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.