Cheap flights from RSW to FLO (Southwest Florida Intl. to Florence Regional)

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Cheap Flights from RSW to FLO starting at $282 One Way, $793 Round Trip

Prices starting at $793 for return flights and $282 for one-way flights to Florence Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Jan 22 - Fri, Jan 23
RSW
Fort Myers
FLO
Florence
$793 Roundtrip, found 2 days ago
$793
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 22 from Fort Myers to Florence, returning Fri, Jan 23, priced at $793 found 2 days ago
Thu, Jan 22 - Fri, Jan 23
RSW
Fort Myers
FLO
Florence
$896 Roundtrip, found 2 days ago
$896
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 22 from Fort Myers to Florence, returning Fri, Jan 23, priced at $896 found 2 days ago
Thu, Jan 22 - Fri, Jan 23
RSW
Fort Myers
FLO
Florence
$919 Roundtrip, found 2 days ago
$919
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 22 from Fort Myers to Florence, returning Fri, Jan 23, priced at $919 found 2 days ago
Thu, Jan 22 - Fri, Jan 23
RSW
Fort Myers
FLO
Florence
$978 Roundtrip, found 2 days ago
$978
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 22 from Fort Myers to Florence, returning Fri, Jan 23, priced at $978 found 2 days ago

Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$100 nightly
The price is $112 total per night from Jan 19 to Jan 20
$112 total
Jan 19 - Jan 20
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,003 reviews)
N/A

Reviewed on Jan 1, 2026

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Jan 18 to Jan 19
$146 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (609 reviews)
Very nice facility; lots of character. Convenient parking. Good breakfast. Very pleasant staff. Would definitely return.

Reviewed on Dec 23, 2025

Hotel Florence, Tapestry Collection by Hilton
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Florence SC
$205 nightly
The price is $230 total per night from Jan 11 to Jan 12
$230 total
Jan 11 - Jan 12
Total with taxes and fees
Stay at this vacation home in Florence. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Old Greenwood Athletic Park and Drs Bruce and ...
9.8/10 Exceptional! (41 reviews)
Everything was great!

Reviewed on Nov 10, 2025

Walking distance from one of South Carolina's top Medical centers.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$70 nightly
The price is $79 total per night from Jan 11 to Jan 12
$79 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,523 reviews)
Check in was quick, efficient and friendly. The rooms had oleanty of space and were clean.

Reviewed on Jan 7, 2026

Howard Johnson by Wyndham Florence
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$98 nightly
The price is $110 total per night from Jan 25 to Jan 26
$110 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,191 reviews)
Fast check in, comfortable bed, quiet setting and a wonderful breakfast.

Reviewed on Jan 2, 2026

Comfort Inn & Suites Florence Center Area
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$85 nightly
The price is $95 total per night from Jan 11 to Jan 12
$95 total
Jan 11 - Jan 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,226 reviews)
Nice hotel

Reviewed on Jan 2, 2026

Park Inn by Radisson Florence, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Jan 12 to Jan 13
$63 total
Jan 12 - Jan 13
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,001 reviews)
The A/C was a bit difficult to handle. The buttons to change the temperature caused the machine to change between modes settings instead. Not to mention, the room could use some renovating. There was patches of paint just hanging from the ceiling.

Reviewed on Dec 29, 2025

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Jan 11 to Jan 12
$68 total
Jan 11 - Jan 12
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (323 reviews)
Clean room, great for price, stayed with spouse, 2 children and two pets. You can hear cars pulling in and out of this location. There was a homeless guy asking for money but you can encounter that anywhere. No bugs, no concerns. :)

Reviewed on Dec 29, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Jan 13 to Jan 14
$74 total
Jan 13 - Jan 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,001 reviews)
Receptionist was very professional and polite. And took her time to answer every question.

Reviewed on Jan 1, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$106 nightly
The price is $119 total per night from Feb 8 to Feb 9
$119 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,007 reviews)
We came for a hockey game, which was amazingly right across the street! Beautiful, spacious room at an amazing price. Couldn’t have asked for better accommodations. Thank you!

Reviewed on Dec 30, 2025

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$101 nightly
The price is $113 total per night from Jan 14 to Jan 15
$113 total
Jan 14 - Jan 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (33 reviews)
Good stay, breakfast was the only dis appointment, no hot options. Good price, friendly staff very clean room. Thank you!

Reviewed on Dec 29, 2025

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$66 nightly
The price is $74 total per night from Jan 13 to Jan 14
$74 total
Jan 13 - Jan 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,001 reviews)
Receptionist was very professional and polite. And took her time to answer every question.

Reviewed on Jan 1, 2026

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

RSW to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

What is the shortest flight from Southwest Florida Intl. Airport (RSW) to Florence Regional Airport?
If you're a firm believer that your vacation hours should be spent 'vacationing' rather than flying, you'll enjoy the flight from Southwest Florida Intl. Airport (RSW) to Florence Regional Airport (FLO). It's a short and sweet 2 hours and 58 minutes.
How many hours flight from RSW to Florence Regional Airport (FLO)?
On a normal day, the trip from RSW to Florence Regional Airport takes 3 hours and 6 minutes. If you want to be as comfortable as possible, try upgrading your seat using miles or cash.
What airlines have the most flights from Southwest Florida Intl. Airport (RSW) to Florence Regional Airport?
At the moment, you can't fly direct from RSW to Florence Regional Airport. However, you will be able to book flights with one or more stops. Look on the positive side — use the time to stretch your travel-weary legs or sit down for a nice coffee!

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.