
$142 Cheap flight deals from St. Louis (STL) to Medellin (MDE)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
Airfares from $142 One Way, $393 Round Trip from St. Louis to Medellin
Prices starting at $393 for return flights and $142 for one-way flights to Medellin were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Medellin economy flight packages



York Luxury Suites Medellín
Dec 31 - Jan 2
St. Louis (STL) to Medellín (MDE)
Reviewed on Sep 28, 2025
More About Flying To Medellin from St. Louis
Route Information for Flights from St. Louis to Medellin
Origin Airport IATA Code | STL |
|---|---|
Destination Airport IATA Code | MDE |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
St. Louis to Medellin
The perfect trip begins with Orbitz. From booking your flights from St. Louis to Medellin to finding the best hotels, Orbitz has got it covered.
Stress-free Searching
With an easy to use system, Orbitz takes the stress and expense out of travel. Not only does Orbitz match your St. Louis to Medellin flights to your ideal hotel, the Display Matrix shows your deals and discounts, including free nights and other savings.
Be One Step Ahead
Need to know what is going on at the airport before you get there? With Orbitz’s free alerts service, you can quickly find out about any booking changes, or flight from St. Louis to Medellin disruptions, saving you hours of wasted time. And if you are being picked up at the airport after your St. Louis to Medellin flights, have alerts sent straight to your contact’s mobile phone or email.
Cutting-Edge Mobile Tools
Find the best price on flights from St. Louis to Medellin with Orbitz’s mobile apps for iPhone and Android. Use m.orbitz.com on your mobile browser to check your gate, baggage allowance and delays, or find exclusive deals on hotels only available to mobile users.
We Work, you Rest and Play
Not only does booking with us ensure guaranteed low prices, but Orbitz does the hard work, leaving you to relax. Just tell us what you want, from St. Louis to Medellin flights, to great deals on hotels and car rental, and activities and tours, and we will do all the rest.
Frequently asked questions
Flights to Medellin
- New York to Medellin
- Los Angeles to Medellin
- Orlando to Medellin
- Toronto to Medellin
- Bogotá to Medellin
- Houston to Medellin
- Chicago to Medellin
- Montreal to Medellin
- San Francisco to Medellin
- Pereira to Medellin
- Barranquilla to Medellin
- Buenos Aires to Medellin
- Sao Paulo to Medellin
- Bucaramanga to Medellin
Flights from St. Louis
- St. Louis to Orlando
- St. Louis to New York
- St. Louis to Houston
- St. Louis to Dallas
- St. Louis to Chicago
- St. Louis to Denver
- St. Louis to Atlanta
- St. Louis to Phoenix
- St. Louis to Los Angeles
- St. Louis to New Orleans
- St. Louis to Toronto
- St. Louis to Detroit
- St. Louis to Washington
- St. Louis to Kansas City
- St. Louis to London
- St. Louis to Cleveland
- St. Louis to San Francisco
- St. Louis to Rome
- St. Louis to Montreal
- St. Louis to Vancouver
St. Louis Airports
Medellin Airports
More Destinations
- Business Hotels in Antioquia
- Kid Friendly Hotels in Antioquia
- Hotels with Hot Tubs in Antioquia
- Pet Friendly Hotels in Antioquia
- Spa Resorts & in Antioquia
- Hotels with a Wedding Venue in Antioquia
- Antioquia Hotels
- Hotels near Explora Park
- Amaga Hotels
- Cottages in Itagüí
- Extended Stay Hotels in Itagüí
- Itagüí Hotels
- Girardota Hotels
- San Diego Hotels
- Spa Resorts & in Laureles
- Cabin Rentals in Guarne
- Guarne Hotels
- Hotels near Piedras Blancas Ecological Park
- Marinilla Hotels
- Manrique Hotels
- Cabin Rentals in San Jerónimo
- San Jerónimo Hotels
- Villas in San Jerónimo
- Apartments in Bello
- Farmstay in Retiro
- Retiro Hotels
- San Javier Hotels
- Condo Rentals in Envigado
- Guest Houses in Envigado
- Envigado Hotels
- Hotels near Arvi Park
- Hotels near Golden Mile
- Cabin Rentals in Rionegro
- Rionegro Hotels
- Villas in Rionegro
- Hotels near Botero Plaza
- La Candelaria Hotels
- Hotels near Hospital Universitario San Vicente de Paul
- San Antonio de Prado Hotels
- Hotels with Free Airport Shuttle in Medellín
- Hotels near Hospital Pablo Tobon Uribe
- Hotels near Atanasio Giradot Stadium
- Cheap Hotels in El Poblado
- Kid Friendly Hotels in El Poblado
- Gay Friendly Hotels in El Poblado
- Hotels with Balconies in El Poblado
- Hotels with an Indoor Pool in El Poblado
- Hotels with a Wedding Venue in El Poblado
- El Poblado Hotels
- Hotels near Medellín Clinic - El Poblado
- Hotels near Lleras Park
- Extended Stay Hotels in Santa Elena
- Hotels near José María Córdova Intl.
- Estadio Hotels
- El Rosario Hotels
- Hotels near Llanogrande Mall
- Extended Stay Hotels in San Antonio de Pereira
- San Antonio de Pereira Hotels
- Apartments in Sabaneta
- Condo Rentals in Sabaneta
- Cottages in Sabaneta
- Sabaneta Hotels
- Flights to Antioquia
- Flights from Itagüí
- Flights from Bello
- Flights from Envigado
- Flights to Rionegro
- Flights from New York to Rionegro
- Flights from Rionegro
- Flights from Bogotá to Guatapé
- Flights from Buenos Aires to Guatapé
- Flights from Dallas to Guatapé
- Flights from Minneapolis - St. Paul to Guatapé
- Flights from St. Louis to Guatapé
- Flights from Fort Lauderdale to Guatapé
- Flights from Tampa to Guatapé
- Flights from Cali to Guatapé
- Flights from Santa Elena
- Flights from José María Córdova Intl.
- Flights from Bogotá (BOG) to Medellín (MDE)
- Flights from New York (JFK) to Medellín (MDE)
- Flights from Los Angeles (LAX) to Medellín (MDE)
- Flights from Miami (MIA) to Medellín (MDE)
- Car rentals near Antioquia
- Car rental Rionegro
- Car rentals near Plaza Cisneros
- Alamo Rent A Car Rental Cars in José María Córdova Intl.
- Avis Rental Cars in José María Córdova Intl.
- Budget Rental Cars in José María Córdova Intl.
- Dollar Rent A Car Rental Cars in José María Córdova Intl.
- Enterprise Rental Cars in José María Córdova Intl.
- Europcar Rental Cars in José María Córdova Intl.
- Fox Rental Cars Rental Cars in José María Córdova Intl.
- Hertz Rental Cars in José María Córdova Intl.
- Payless Rental Cars in José María Córdova Intl.
- Car rental Sabaneta
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

