Book 5 Star Hotels in Downtown Buffalo

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Featured Downtown Buffalo 5 Stars Hotels

Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza Buffalo NY
0.37 mi from Downtown Buffalo
$143 nightly
The price is $167 total per night
$167 total
Jan 19 - Jan 20, 2026
Total with taxes and fees
At Hyatt Regency Buffalo / Hotel and Conference Center, guests enjoy features like an indoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is offered for USD 29.50 per night. The front desk has multilingual staff on hand 24/7 to help with securing valuables, dry cleaning/laundry, and concierge services. Additional amenities include meeting rooms, a conference center, and a business center.
Pool
Pet friendly
Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

2.5 out of 5
601 Main St Buffalo NY
Free Cancellation
0.39 mi from Downtown Buffalo
$112 nightly
The price is $131 total per night
$131 total
Jan 26 - Jan 27, 2026
Total with taxes and fees
Guests of Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG enjoy a gym, free WiFi in public areas, and a business center. Front-desk staff can answer questions 24/7, and assist with securing valuables, dry cleaning/laundry, and luggage storage. Additional amenities include express check-out, laundry facilities, and a vending machine.
Breakfast included
Free WiFi
Hilton Garden Inn Buffalo Downtown

Hilton Garden Inn Buffalo Downtown

3 out of 5
10 Lafayette Square Buffalo NY
Free Cancellation
Reserve now, pay when you stay
0.53 mi from Downtown Buffalo
$105 nightly
The price is $123 total per night
$123 total
Jan 19 - Jan 20, 2026
Total with taxes and fees
At Hilton Garden Inn Buffalo Downtown, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. The front desk is staffed 24/7 to help with luggage storage, securing valuables, and dry cleaning/laundry. Additional amenities include meeting rooms, conference space, and coffee/tea in a common area.
Pool
Pet friendly
Hampton Inn & Suites Buffalo Downtown

Hampton Inn & Suites Buffalo Downtown

2.5 out of 5
220 Delaware Ave Buffalo NY
Free Cancellation
Reserve now, pay when you stay
0.19 mi from Downtown Buffalo
$130 nightly
The price is $152 total per night
$152 total
Jan 20 - Jan 21, 2026
Total with taxes and fees
Guests staying at Hampton Inn & Suites Buffalo Downtown enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 20 per day. The front desk has multilingual staff on hand 24/7 to help with dry cleaning/laundry, securing valuables, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a hot tub, conference space, and coffee/tea in a common area.
Pool
Hot Tub
Wyndham Garden Buffalo Downtown

Wyndham Garden Buffalo Downtown

3 out of 5
125 High St Buffalo NY
0.95 mi from Downtown Buffalo
$124 nightly
The price is $144 total per night
$144 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
At Wyndham Garden Buffalo Downtown, guests have access to a 24-hour gym, free WiFi in public areas, and a 24-hour business center. For transportation, you can make use of an airport shuttle (available on request) for USD 25.00 per room one-way, as well as a free area shuttle. The front desk has multilingual staff standing by 24 hours a day to assist with concierge services and luggage storage. Additional amenities include coffee/tea in a common area, express check-in, and express check-out.
Breakfast included
Free WiFi
Curtiss Hotel, an Ascend Collection Hotel

Curtiss Hotel, an Ascend Collection Hotel

5 out of 5
210 Franklin St Buffalo NY
Free Cancellation
0.28 mi from Downtown Buffalo
$208 nightly
The price is $243 total per night
$243 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
Guests staying at Curtiss Hotel, an Ascend Collection Hotel enjoy access to a full-service spa, a 24-hour gym, and a rooftop terrace. You can put free valet parking to good use if you drive. The 24-hour front desk has multilingual staff ready to assist with tours or tickets, dry cleaning/laundry, and luggage storage. Other amenities at this luxury hotel include free WiFi in public areas, meeting rooms, and a 24-hour business center.
Breakfast included
Spa
The Mansion On Delaware Ave

The Mansion On Delaware Ave

4 out of 5
414 Delaware Ave Buffalo NY
Free Cancellation
Reserve now, pay when you stay
0.33 mi from Downtown Buffalo
$199 nightly
The price is $228 total per night
$228 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
At The Mansion On Delaware Ave, guests have access to a 24-hour gym, free WiFi in public areas, and meeting rooms. You can take advantage of free parking if you drive. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, securing valuables, and tours or tickets. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Breakfast included
Parking included
Courtyard Buffalo Downtown / Canalside

Courtyard Buffalo Downtown / Canalside

3 out of 5
One Canalside, 125 Main Street Buffalo NY
Free Cancellation
Reserve now, pay when you stay
1.02 mi from Downtown Buffalo
$195 nightly
The price is $227 total per night
$227 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
At Courtyard Buffalo Downtown / Canalside, guests enjoy features like an indoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 18 per night. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this golf hotel include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub
Hotel at the Lafayette Trademark Collection by Wyndham

Hotel at the Lafayette Trademark Collection by Wyndham

3.5 out of 5
391 Washington St Buffalo NY
Free Cancellation
Reserve now, pay when you stay
0.6 mi from Downtown Buffalo
$109 nightly
The price is $127 total per night
$127 total
Jan 26 - Jan 27, 2026
Total with taxes and fees
Dating back to 1904, Hotel at the Lafayette Trademark Collection by Wyndham offers a 24-hour gym, free WiFi in public areas, and a fireplace in the lobby. There's free offsite parking and a bus station shuttle. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include an ATM, wedding services, and a banquet hall.
Free WiFi
Air conditioning
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best 5 star hotels in Downtown Buffalo

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in Downtown Buffalo. After all, treating yourself to the finer things is what vacations are about. 

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These Downtown Buffalo hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
Downtown Buffalo 5 star hotels and resorts typically offer luxury amenities such as:

  • Gourmet restaurant
  • Full-service fitness center with pool
  • Luxury spa 
  • Welcome gifts upon arrival
  • Top-of-the-line beds and linens 
  • Designer personal care products
  • Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in Downtown Buffalo with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place: 

  • Search hotels by price, ranging from $123 to $243
  • Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
  • Choose from 1,227 5 star hotels in Downtown Buffalo!

Downtown Buffalo hotels essential information

Accommodation
1,227 hotels
Lowest Price
$123
Highest Price
$243
Popular hotels
Hyatt Regency Buffalo / Hotel and Conference Center, Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG, Hilton Garden Inn Buffalo Downtown, Hampton Inn & Suites Buffalo Downtown, Wyndham Garden Buffalo Downtown, Curtiss Hotel, an Ascend Collection Hotel, The Mansion On Delaware Ave, Courtyard Buffalo Downtown / Canalside, Hotel at the Lafayette Trademark Collection by Wyndham

Recent Reviews

Hilton Garden Inn Buffalo Downtown

Hilton Garden Inn Buffalo Downtown

5/5 Excellent
"Everything was amazing even the front desk very helpful and very knowledgeable about the area. Thanks for the hospitality "
A verified traveler stayed at Hilton Garden Inn Buffalo Downtown
Posted 4 days ago
Hilton Garden Inn Buffalo Downtown