Holiday Inn Express & Suites St. Louis South - I-55 by IHG
Hotel in St. Louis with free breakfast and a 24-hour fitness center
Choose dates to view prices
Photo gallery for Holiday Inn Express & Suites St. Louis South - I-55 by IHG





Reviews
9.6 out of 10
Exceptional
Popular amenities
Explore the area

4250 Midamerica Lane, St. Louis, MO, 63129
- Barnes Jewish South Campus5 min walk
- Mercy Hospital South5 min drive
- Grant's Farm11 min drive
- St. Louis, MO (STL-Lambert-St. Louis Intl.)34 min drive
Room options
View all photos for Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)
9.4 out of 10
Exceptional
(13 reviews)
View all photos for Suite, 1 Bedroom (2 Queen, Extra Living Area)

Suite, 1 Bedroom (2 Queen, Extra Living Area)
9.4 out of 10
Exceptional
(24 reviews)
View all photos for Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

Standard Room, 2 Queen Beds, Accessible (Mobil Tub)
9.6 out of 10
Exceptional
(4 reviews)
View all photos for Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)
10.0 out of 10
Exceptional
(1 review)
View all photos for Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)
9.0 out of 10
Wonderful
(7 reviews)
View all photos for Standard Room, 1 King Bed (Bath Shwr Combo)

Standard Room, 1 King Bed (Bath Shwr Combo)
9.8 out of 10
Exceptional
(13 reviews)
View all photos for Suite, 1 King Bed (Extra Living, Walk in Shwr)

Suite, 1 King Bed (Extra Living, Walk in Shwr)
9.0 out of 10
Wonderful
(4 reviews)
View all photos for Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)
View all photos for Standard Room

Standard Room
View all photos for Standard Room, 2 Queen Beds

Standard Room, 2 Queen Beds
9.4 out of 10
Exceptional
(68 reviews)
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- Pool
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7.8 out of 10, Good, 1,008 reviews
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The price is $136
Jul 20 - Jul 21
Total includes taxes and fees
About the neighborhood
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Holiday Inn St Louis SW - Route 66 by IHG
Holiday Inn St Louis SW - Route 66 by IHG
- Pool
- Pet friendly
- Parking included
- Restaurant
9.0 out of 10, Wonderful, 294 reviews
$121 nightly
The price is $142
Jul 20 - Jul 21
Total includes taxes and fees
Property amenities
Room amenities
Policies
Important information
Frequently asked questions
Holiday Inn Express & Suites St. Louis South - I-55 by IHG Reviews
Reviews
9.6
Exceptional
9.6/10
Cleanliness
9.6/10
Staff & service
9.6/10
Amenities
9.6/10
Property conditions & facilities
9.4/10
Eco-friendliness
Reviews
Apr 10, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Apr 2025
10/10 Excellent
Verified traveler
Business traveler
Apr 9, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great place
Verified traveler
Stayed 1 night in Apr 2025
8/10 Good
Christina
Traveled with family
Apr 2, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Christina
Stayed 1 night in Mar 2025
8/10 Good
Thomas
Apr 1, 2025
Thomas
Stayed 1 night in Mar 2025
10/10 Excellent
Trisha
Traveled with family
Mar 31, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Trisha
Stayed 1 night in Mar 2025
10/10 Excellent
Susan
Traveled with family
Mar 30, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Susan
Stayed 2 nights in Mar 2025
10/10 Excellent
Susan
Traveled with family
Mar 30, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Susan
Stayed 1 night in Mar 2025
10/10 Excellent
Nobuyuki
Traveled with family
Mar 30, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Nobuyuki
Stayed 2 nights in Mar 2025
8/10 Good
rebecca
Mar 29, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
rebecca
Stayed 1 night in Dec 2024
10/10 Excellent
Verified traveler
Traveled with family
Mar 29, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Verified traveler
Stayed 1 night in Mar 2025
10/10 Excellent
Stephanie
Traveled with family
Mar 27, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great hotel for families
Stephanie
Stayed 2 nights in Mar 2025
2/10 Terrible
Chissolssi
Traveled with family
Mar 27, 2025
Liked: Property conditions & facilities
Disliked: Cleanliness, room comfort
Soiled sheets
Chissolssi
Stayed 2 nights in Mar 2025
8/10 Good
Michael
Business traveler
Mar 27, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
Michael
Stayed 5 nights in Mar 2025
10/10 Excellent
George
Mar 26, 2025
Liked: Staff & service
George
Stayed 2 nights in Mar 2025
8/10 Good
kimberly
Mar 25, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
kimberly
Stayed 1 night in Jan 2025
10/10 Excellent
Ryan
Mar 23, 2025
Ryan
Stayed 2 nights in Feb 2025
10/10 Excellent
Jacqueline
Traveled with family
Mar 21, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great property
Jacqueline
Stayed 1 night in Mar 2025
6/10 Okay
Tiffany
Mar 6, 2025
Tiffany
Stayed 1 night in Feb 2025
10/10 Excellent
Brian W
Feb 25, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Nice clean hotel
Brian W
Stayed 2 nights in Feb 2025
10/10 Excellent
Matthew
Traveled with family and small children, Traveled with family
Feb 23, 2025
Liked: Cleanliness, staff & service, amenities
Matthew
Stayed 4 nights in Feb 2025
10/10 Excellent
Damon
Traveled with partner
Feb 21, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
Damon
Stayed 1 night in Feb 2025
10/10 Excellent
Megan
Traveled with family
Feb 18, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Megan
Stayed 2 nights in Feb 2025
6/10 Okay
Shannon
Feb 14, 2025
Shannon
Stayed 2 nights in Feb 2025
10/10 Excellent
Debbie
Traveled with family
Feb 13, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Perfect
Debbie
Stayed 1 night in Feb 2025
10/10 Excellent
Mary
Feb 12, 2025
Liked: Cleanliness, staff & service, room comfort
Mary
Stayed 1 night in Feb 2025
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