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Holiday Inn Express & Suites St. Louis South - I-55 by IHG

2.5 star property
Hotel in St. Louis with free breakfast and a 24-hour fitness center

Choose dates to view prices

Photo gallery for Holiday Inn Express & Suites St. Louis South - I-55 by IHG

Exterior
Property amenity
Standard Room, 2 Queen Beds, Accessible (Mobil Tub) | In-room safe, desk, laptop workspace, blackout drapes
Exterior
Property amenity

Reviews

9.6 out of 10
Exceptional

Popular amenities

  • Pool
  • Housekeeping
  • Gym
  • Air conditioning

Explore the area

View in a map
4250 Midamerica Lane, St. Louis, MO, 63129
  • Place, Barnes Jewish South Campus
    ‪5 min walk‬
  • Place, Gateway Arch
    ‪17 min drive‬
  • Place, St. Louis Union Station
    ‪18 min drive‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪30 min drive‬

Room options

View all photos for Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

Room amenity

Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

9.4 out of 10
Exceptional
(13 reviews)
  • 300 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

Standard Room, 2 Queen Beds, Accessible (Mobil Tub) | In-room safe, desk, laptop workspace, blackout drapes

Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

9.6 out of 10
Exceptional
(4 reviews)
  • 300 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Suite, 1 Bedroom (2 Queen, Extra Living Area)

Room amenity

Suite, 1 Bedroom (2 Queen, Extra Living Area)

9.4 out of 10
Exceptional
(27 reviews)
  • 300 sq ft
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

Room amenity

Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

9.0 out of 10
Wonderful
(7 reviews)
  • 300 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

Free toiletries, hair dryer, towels, soap

Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

10.0 out of 10
Exceptional
(1 review)
  • 300 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Extra Living, Walk in Shwr)

Suite, 1 King Bed (Extra Living, Walk in Shwr) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Extra Living, Walk in Shwr)

9.0 out of 10
Wonderful
(4 reviews)
  • 300 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 1 King Bed (Bath Shwr Combo)

Room amenity

Standard Room, 1 King Bed (Bath Shwr Combo)

9.8 out of 10
Exceptional
(15 reviews)
  • 300 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room

Standard Room | In-room safe, desk, laptop workspace, blackout drapes

Standard Room

  • 300 sq ft
  • Sleeps 2
  • 1 Twin Bed

View all photos for Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

  • 300 sq ft
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 2 Queen Beds

Room amenity

Standard Room, 2 Queen Beds

9.4 out of 10
Exceptional
(72 reviews)
  • 300 sq ft
  • Sleeps 4
  • 2 Queen Beds

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Hampton Inn & Suites St. Louis/South I-55

St. Louis
  • Pool
  • Breakfast included
  • Pet friendly
  • Parking included
9.6 out of 10, Exceptional, 1,002 reviews
$111 nightly
The price is $128
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hampton Inn & Suites St. Louis/South I-55

About the neighborhood

St. Louis

Located within a leisurely stroll of Barnes Jewish South Campus, Holiday Inn Express & Suites St. Louis South - I-55 by IHG is within a few miles (5 km) of St Anthony's. This 99-room hotel has free breakfast along with conveniences like an indoor pool and a 24-hour gym.

What's nearby

  • Barnes Jewish South Campus - 5 min walk - 0.3 miles
  • Gateway Arch - 17 min drive - 17.3 miles
  • Enterprise Center - 17 min drive - 16.7 miles
  • St. Louis Union Station - 18 min drive - 16.9 miles
  • St. Louis Zoo - 21 min drive - 16.4 miles

Getting around

  • Kirkwood Station - 17 min drive
  • St. Louis Lambert Intl. Airport (STL) - 32 min drive

Restaurants

  • ‪Burger King - ‬10 min walk
  • ‪Popeyes Louisiana Kitchen - ‬4 min walk
  • ‪Starbucks - ‬9 min walk
  • ‪Rich & Charlie's Italian Restaurant - ‬3 min drive
  • ‪Taco Bell - ‬11 min walk

About this property

Holiday Inn Express & Suites St. Louis South - I-55 by IHG

Hotel in St. Louis with free breakfast and a 24-hour fitness center
Guests staying at Holiday Inn Express & Suites St. Louis South - I-55 by IHG enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has staff standing by to help secure valuables, and answer any questions about the accommodations. Additional amenities include meeting rooms, a business center, and a vending machine.
49-inch flat-screen TVs come with cable channels, and guests can stay connected with free WiFi and wired Internet. Bathrooms have hair dryers and free toiletries. Refrigerators, microwaves, and coffee makers are also available. Housekeeping is available on request.
Recreational amenities at the hotel include an indoor pool and a 24-hour fitness center.

Similar properties

Exterior
Fairfield Inn & Suites by Marriott St. Louis South
  • Pool
  • Breakfast included
  • Parking included
  • Free WiFi
9.6 out of 10, Exceptional, 325 reviews
$116 nightly
The price is $134
Dec 28 - Dec 29
Total with taxes and fees
Fairfield Inn & Suites by Marriott St. Louis South

Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available daily 6:00 AM to 9:30 AM

Things to do

  • 24-hour gym
  • Indoor pool

Family friendly

  • In-room crib
  • In-room microwave
  • In-room refrigerator
  • Indoor pool

Conveniences

  • 24-hour front desk
  • Safe at front desk
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Elevator
  • Stair-free path to entrance
  • Visual alarms in hallways
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible van parking

More

  • 4 floors
  • At least 10% of profits reinvested in community and sustainability
  • Banquet hall
  • No plastic drinking straws
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes
  • Free crib

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 49-inch flat-screen TV with cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Refrigerator

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: 2:30 AM
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

  • Service animals exempt from fees

Children and extra beds

  • Free cribs/infant beds are available

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)
  • Check-in: 3:00 PM
  • Check-out: 11 AM
  • Minimum check-in age: 21
The front desk is open 24 hours a day. Driving? This property offers free parking.

We should mention

Details about charges, deposits, or other important information:

  • This property is managed by a professional host. The provision of housing is linked to their trade, business, or profession.
  • Charges for extra guests may apply and vary depending on the property's policy.
  • A cash deposit, credit card, or debit card for incidental charges, as well as a government-issued photo ID, may be required at check-in.
  • Special requests are subject to availability at the time of check-in and can't be guaranteed. Certain requests may come with additional charges.
  • This property accepts credit cards. Cash is not accepted. 
  • This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG).

Additional information about polices, regulations, and more:

  • Pool access available from 8 AM to 10 PM.
  • Connecting or adjoining rooms can be requested, but all rooms are subject to availability. Contact the property using the phone number on your booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

Property is also known as

Holiday Inn Express St. Louis South I-55 Hotel
Holiday Inn Express St. Louis South I-55
Inn Express St Louis I55
Holiday Inn Express Suites St. Louis South I 55
Holiday Inn Express Suites St. Louis South I 55 by IHG
Holiday Inn Express Suites St. Louis South I 55 an IHG Hotel
Holiday Inn Express & Suites St. Louis South - I-55 by IHG Hotel

Frequently asked questions

Is a free cancellation option available at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Holiday Inn Express & Suites St. Louis South - I-55 by IHG offers free cancellation on select room rates. To learn more, take a look at the cancellation policy on our site.

How much does it cost to stay at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

As of Dec 9, 2025, prices found for a 1-night stay for 2 adults at Holiday Inn Express & Suites St. Louis South - I-55 by IHG on Jan 2, 2026 start from $105.0, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

What is there to do close to Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

This hotel is located in St. Louis, close to Grant's Farm, River City Casino, and Jefferson Barracks Historic Park. You'll also find Meramec River and Suson Park within a short drive.

Will I be able to park at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Yes, self parking is offered for free at the hotel. Accessible parking is also available for guests.

Does Holiday Inn Express & Suites St. Louis South - I-55 by IHG include a casino at the property?

No, Holiday Inn Express & Suites St. Louis South - I-55 by IHG doesn't have a casino.

Will I find an indoor pool at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Yes, this hotel has an indoor pool. Guests have pool access between 8 AM and 10 PM.

What will couples enjoy most about a stay at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Couples staying at this hotel will appreciate amenities like free Internet access as well as an indoor pool and a 24-hour fitness facility.

Does Holiday Inn Express & Suites St. Louis South - I-55 by IHG have a hot tub?

No, this hotel doesn't have a spa tub.

Does Holiday Inn Express & Suites St. Louis South - I-55 by IHG feature a restaurant that includes a breakfast menu?

Holiday Inn Express & Suites St. Louis South - I-55 by IHG offers free buffet breakfast each morning though there is no restaurant.

Will Holiday Inn Express & Suites St. Louis South - I-55 by IHG allow pets to stay for free?

No, pets aren't allowed at Holiday Inn Express & Suites St. Louis South - I-55 by IHG though service animals are welcome.

Are there connecting rooms at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Yes, this hotel has connecting guestrooms you can book for your group event or vacation.

What is the closest airport to Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

The closest major airport to Holiday Inn Express & Suites St. Louis South - I-55 by IHG is St. Louis Lambert Intl. Airport (STL), which is 26.1 mi away (32 minutes by car). Another top airport is St. Louis, MO (SUS-Spirit of St. Louis), which is located 26.2 mi away (32-minute drive).

Can I book a room with a balcony at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

No, there aren't any guestrooms with balconies at Holiday Inn Express & Suites St. Louis South - I-55 by IHG.

Holiday Inn Express & Suites St. Louis South - I-55 by IHG Reviews

Reviews

9.6

Exceptional

Rating 10 - Excellent. 802 out of 1002 reviews
Rating 8 - Good. 145 out of 1002 reviews
Rating 6 - Okay. 35 out of 1002 reviews
Rating 4 - Poor. 14 out of 1002 reviews
Rating 2 - Terrible. 6 out of 1002 reviews

9.6/10

Cleanliness

9.6/10

Staff & service

9.6/10

Amenities

9.6/10

Property conditions & facilities

9.4/10

Eco-friendliness

Reviews

10/10 Excellent

John C

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Staff was amazing
Stayed 2 nights in Sep 2025

10/10 Excellent

Marilyn

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Comfortable & Relaxing

My family and I were in transit to a family reunion in Wisconsin. We had double reservations here and back. Both times were very satisfying and great. Amazing breakfast and love cookie hour.
Stayed 1 night in Sep 2025

10/10 Excellent

Maria

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Sep 2025

10/10 Excellent

Kaylee

Stayed 1 night in Aug 2025

8/10 Good

Laura

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Great place!

Hotel is always super clean, staff is very friendly and breakfast buffet is awesome. We stayed on the first floor in a standard room, but will book a suite next time. They were all booked up.
Stayed 2 nights in Aug 2025

8/10 Good

margaret

Traveled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Good stay!

Nice spacious room with many device connections. Towels were a bit week
Stayed 1 night in Aug 2025

10/10 Excellent

Verified traveler

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
The girls at the front desk were very friendly. The nightly milk & cookies were a big hit!
Stayed 2 nights in Aug 2025

10/10 Excellent

Marilyn

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Clean, fast, & friendly!

We are currently still checked in and had the most delicious & well presented breakfast. Coffee is excellent, and breakfast area is cleaned. The breakfast server was very friendly & respectful.
Stayed 1 night in Aug 2025

8/10 Good

Francis

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
When I went to the Fitness room my key didn't open the door. There was no one at the desk for me to ask about it. It was about 7:30 AM.
Stayed 1 night in Aug 2025

10/10 Excellent

Cresley

Traveled with family and small children, Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I have stayed at this property multiple times and it’s always a good experience. The staff are friendly and do an excellent job at keeping up the facility. I look forward to returning.
Stayed 1 night in Aug 2025

8/10 Good

James

Stayed 2 nights in Aug 2025

10/10 Excellent

Linda

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Tameka, Memphis

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay and clean hotel. I had a double queen and the room was very spacious. Great breakfast option and friendly staff.
Stayed 1 night in Aug 2025

10/10 Excellent

Sujata

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

8/10 Good

Melinda

Stayed 1 night in Jul 2025

10/10 Excellent

Ryan Gerald

Business traveler
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice people, clean room, good breakfast
Stayed 1 night in Jul 2025

10/10 Excellent

Jude

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Bryan

Liked: Cleanliness, staff & service, property conditions & facilities
A
Stayed 1 night in Aug 2025

8/10 Good

Jimmy

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in May 2025

10/10 Excellent

John

Traveled with family and small children, Traveled with family
Liked: Cleanliness, amenities, property conditions & facilities
Our family loved cookie hour!
Stayed 3 nights in Jul 2025

10/10 Excellent

Ray

Liked: Cleanliness, staff & service, property conditions & facilities
Great hotel
Stayed 6 nights in Jul 2025

6/10 Okay

Megan

Liked: Cleanliness, property conditions & facilities, room comfort
Stayed 1 night in Jun 2025

10/10 Excellent

kerrie

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was clean property
Stayed 1 night in Jul 2025

8/10 Good

Barbara

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jul 2025

10/10 Excellent

Becca

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025

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