Hotels in South Main
Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels
Save 10% or more on select hotels with Insider Prices
Book on the app to instantly earn 5% on 350,000+ hotels
Featured Hotels in South Main

Wyndham Houston near NRG Park/Medical Center
8686 Kirby Drive Houston TX
0.49 mi from South Main
$93 nightly
The price is $108 total per night
$108 total
Apr 19 - Apr 20
Total with taxes and fees
At Wyndham Houston near NRG Park/Medical Center, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Limited parking is available. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, luggage storage, and concierge services. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Pet friendly

Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Free Cancellation
Reserve now, pay when you stay
2.16 mi from South Main
$158 nightly
The price is $185 total per night
$185 total
May 14 - May 15
Total with taxes and fees
Blossom Hotel Houston, Curio Collection by Hilton features a full-service spa, an outdoor pool, and a 24-hour gym. Valet parking is available for USD 49 per night, and there's also limo/town car service. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this spa hotel include a rooftop terrace, free WiFi in public areas, and meeting rooms.
Pool
Spa

Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Free Cancellation
Reserve now, pay when you stay
3.93 mi from South Main
$237 nightly
The price is $277 total per night
$277 total
Apr 19 - Apr 20
Total with taxes and fees
Hotel Zaza Houston Museum District features a full-service spa, an outdoor pool, and a 24-hour gym. Valet parking is available for USD 60 per night, and there's also a free area shuttle. Front-desk staff can answer questions 24/7, and assist with luggage storage, securing valuables, and dry cleaning/laundry. Other amenities at this luxury hotel include a sauna, free WiFi in public areas, and conference space.
Pool
Pet friendly

The Royal Sonesta Houston Galleria
2222 West Loop South Houston TX
Free Cancellation
Reserve now, pay when you stay
5.49 mi from South Main
$149 nightly
The price is $174 total per night
$174 total
May 8 - May 9
Total with taxes and fees
Guests staying at The Royal Sonesta Houston Galleria enjoy an outdoor pool, a 24-hour gym, and WiFi in public areas. Parking is available for USD 34.00 per night (USD 45.00 per night for valet parking), and there's also an area shuttle. Multilingual staff at the 24-hour front desk can assist with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include meeting rooms, a conference center, and a 24-hour business center.
Pool
Pet friendly

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
Free Cancellation
Reserve now, pay when you stay
5.5 mi from South Main
$119 nightly
The price is $139 total per night
$139 total
Apr 26 - Apr 27
Total with taxes and fees
At DoubleTree by Hilton Hotel & Suites Houston by the Galleria, guests enjoy features like an outdoor pool, a 24-hour gym, and WiFi in public areas. Parking is available for USD 32 per night (USD 46.00 per night for valet parking), and there's also a free area shuttle. The 24-hour front desk has multilingual staff ready to assist with luggage storage and dry cleaning/laundry. Additional amenities include conference space, a business center, and a seasonal outdoor pool.
Pool
Pet friendly

The Whitehall Houston
1700 Smith St Houston TX
Free Cancellation
Reserve now, pay when you stay
6.2 mi from South Main
$122 nightly
The price is $142 total per night
$142 total
Apr 26 - Apr 27
Total with taxes and fees
At The Whitehall Houston, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 50 per night, and there's also a free area shuttle. The front desk has multilingual staff on hand 24/7 to help with luggage storage, concierge services, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include meeting rooms, a conference center, and a 24-hour business center.
Pool
Pet friendly

Heritage Place Houston Brookhollow
2504 North Loop West Houston TX
Free Cancellation
Reserve now, pay when you stay
9.55 mi from South Main
$65 nightly
The price is $77 total per night
$77 total
May 5 - May 6
Total with taxes and fees
Guests of Heritage Place Houston Brookhollow have access to an outdoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with dry cleaning/laundry, securing valuables, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include conference space, a 24-hour business center, and a seasonal outdoor pool.
Pool
Pet friendly

Hilton Houston North
12400 Greenspoint Dr Houston TX
Free Cancellation
Reserve now, pay when you stay
18.94 mi from South Main
$112 nightly
The price is $132 total per night
$132 total
Apr 26 - Apr 27
Total with taxes and fees
Guests of Hilton Houston North enjoy a 24-hour gym, free WiFi in public areas, and meeting rooms. There's free parking, as well as a free airport shuttle (available on request). The front desk is staffed 24/7 to help with concierge services, securing valuables, and luggage storage. Additional amenities include conference space, a business center, and a microwave in a common area.
Free airport shuttle
Parking included

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
15510 JFK Blvd Houston TX
Free Cancellation
Reserve now, pay when you stay
19.35 mi from South Main
$84 nightly
The price is $98 total per night
$98 total
Apr 20 - Apr 21
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Houston Bush IAH South, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking, along with a free airport shuttle (available on request). The 24-hour front desk has multilingual staff ready to help with luggage storage, and answer any questions about the area. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
South Main hotels essential information
Accommodation | 6,793 hotels |
|---|---|
Lowest Price | $77 |
Highest Price | $277 |
Popular hotels | Wyndham Houston near NRG Park/Medical Center, DoubleTree by Hilton Hotel & Suites Houston by the Galleria, Hotel Zaza Houston Museum District, The Royal Sonesta Houston Galleria, Blossom Hotel Houston, Curio Collection by Hilton, Heritage Place Houston Brookhollow, The Whitehall Houston, La Quinta Inn & Suites by Wyndham Houston Bush IAH South, Hilton Houston North |
Popular places to visit

George R. Brown Convention Center
4/5(971 reviews)
During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.

Daikin Park
4.5/5(915 reviews)
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art scene and great live music in this vibrant area.

MD Anderson Cancer Center
4.5/5(802 reviews)
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Recent Reviews

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5/5 Excellent
"They have nice accommodations, the rooms were clean, tastefully done, white bed cover, and the hotel food is actually excellent. The bartender Jonay is an amazing bartender and remembered me. She ordered my Jambalaya as I put my things in my room. Location is perfect to amazing restaurants in Houston."
A verified traveler stayed at DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Posted 3 hours ago
More to Explore
- Car rentals in Houston
- Visit NRG Stadium
- Hotels near MD Anderson Cancer Center
- Cheap Hotels in Houston
- Hotels near NRG Stadium
- Hotels in Texas Medical Center
- Hotels near NRG Park
- Hotels near Rice University
- Flights to Houston
- Hotels in Bellaire
- Hotels in The Galleria
- Hotels in Downtown Houston
- Hotels in Southwest Houston
- Hotels near Houston Zoo
- Hotels in Houston


