Hotels in South Main
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Featured Hotels in South Main

Wyndham Houston near NRG Park/Medical Center
8686 Kirby Drive Houston TX
0.49 mi from South Main
$101 nightly
The price is $118 total per night
$118 total
May 17 - May 18
Total with taxes and fees
At Wyndham Houston near NRG Park/Medical Center, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Limited parking is available. Multilingual staff at the front desk are standing by 24/7 to help with securing valuables, luggage storage, and concierge services. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Pet friendly

Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Free Cancellation
Reserve now, pay when you stay
2.16 mi from South Main
$151 nightly
The price is $177 total per night
$177 total
May 28 - May 29
Total with taxes and fees
Blossom Hotel Houston, Curio Collection by Hilton features a full-service spa, an outdoor pool, and a 24-hour gym. Valet parking is available for USD 49 per night, and there's also limo/town car service. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this spa hotel include a rooftop terrace, free WiFi in public areas, and meeting rooms.
Pool
Spa

Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Free Cancellation
Reserve now, pay when you stay
2.71 mi from South Main
$100 nightly
The price is $117 total per night
$117 total
May 10 - May 11
Total with taxes and fees
Guests staying at Hilton Houston Plaza/Medical Center enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 20 per day. Multilingual staff at the front desk are standing by 24/7 to help with concierge services, securing valuables, and dry cleaning/laundry. Other amenities at this luxury hotel include meeting rooms, conference space, and coffee/tea in a common area.
Pool
Free WiFi

Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Free Cancellation
Reserve now, pay when you stay
3.93 mi from South Main
$246 nightly
The price is $288 total per night
$288 total
May 26 - May 27
Total with taxes and fees
Hotel Zaza Houston Museum District features a full-service spa, an outdoor pool, and a 24-hour gym. Valet parking is available for USD 60 per night, and there's also a free area shuttle. Front-desk staff can answer questions 24/7, and assist with luggage storage, securing valuables, and dry cleaning/laundry. Other amenities at this luxury hotel include a sauna, free WiFi in public areas, and conference space.
Pool
Spa

The Royal Sonesta Houston Galleria
2222 West Loop South Houston TX
Free Cancellation
Reserve now, pay when you stay
5.49 mi from South Main
$138 nightly
The price is $161 total per night
$161 total
May 9 - May 10
Total with taxes and fees
Guests staying at The Royal Sonesta Houston Galleria enjoy an outdoor pool, a 24-hour gym, and WiFi in public areas. Parking is available for USD 34.00 per night (USD 45.00 per night for valet parking), and there's also an area shuttle. Multilingual staff at the 24-hour front desk can assist with securing valuables, luggage storage, and dry cleaning/laundry. Additional amenities include meeting rooms, a conference center, and a 24-hour business center.
Pool
Pet friendly

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
Free Cancellation
Reserve now, pay when you stay
5.5 mi from South Main
$130 nightly
The price is $152 total per night
$152 total
May 8 - May 9
Total with taxes and fees
At DoubleTree by Hilton Hotel & Suites Houston by the Galleria, guests enjoy features like an outdoor pool, a 24-hour gym, and WiFi in public areas. Parking is available for USD 32 per night (USD 46.00 per night for valet parking), and there's also a free area shuttle. The 24-hour front desk has multilingual staff ready to assist with luggage storage and dry cleaning/laundry. Additional amenities include conference space, a business center, and a seasonal outdoor pool.
Pool
Pet friendly

The Whitehall Houston
1700 Smith St Houston TX
Free Cancellation
Reserve now, pay when you stay
6.2 mi from South Main
$139 nightly
The price is $163 total per night
$163 total
May 20 - May 21
Total with taxes and fees
At The Whitehall Houston, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 50 per night, and there's also a free area shuttle. The front desk has multilingual staff on hand 24/7 to help with luggage storage, concierge services, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include meeting rooms, a conference center, and a 24-hour business center.
Pool
Pet friendly

Club Quarters Hotel Downtown, Houston
1085 Rusk Street Houston TX
Free Cancellation
Reserve now, pay when you stay
6.76 mi from South Main
$114 nightly
The price is $133 total per night
$133 total
May 7 - May 8
Total with taxes and fees
At Club Quarters Hotel Downtown, Houston, guests have access to a 24-hour gym, free WiFi in public areas, and meeting rooms. Valet parking is offered for USD 45 per day. Multilingual staff at the 24-hour front desk can assist with securing valuables, concierge services, and luggage storage. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a computer station.
Pet friendly
Free WiFi

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
15510 JFK Blvd Houston TX
Free Cancellation
Reserve now, pay when you stay
19.35 mi from South Main
$88 nightly
The price is $102 total per night
$102 total
May 3 - May 4
Total with taxes and fees
At La Quinta Inn & Suites by Wyndham Houston Bush IAH South, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking, along with a free airport shuttle (available on request). The 24-hour front desk has multilingual staff ready to help with luggage storage, and answer any questions about the area. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Breakfast included
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
South Main hotels essential information
Accommodation | 6,865 hotels |
|---|---|
Lowest Price | $102 |
Highest Price | $288 |
Popular hotels | Wyndham Houston near NRG Park/Medical Center, DoubleTree by Hilton Hotel & Suites Houston by the Galleria, Club Quarters Hotel Downtown, Houston, Blossom Hotel Houston, Curio Collection by Hilton, The Whitehall Houston, Hilton Houston Plaza/Medical Center, The Royal Sonesta Houston Galleria, Hotel Zaza Houston Museum District, La Quinta Inn & Suites by Wyndham Houston Bush IAH South |
Popular places to visit

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MD Anderson Cancer Center
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Recent Reviews

The Whitehall Houston
2/5 Poor
"We stayed a total of 4 nights. Was told we’d get house keeping "
A verified traveler stayed at The Whitehall Houston
Posted 1 hour ago
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