Hotels in South Main
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Featured Hotels in South Main

Wyndham Houston at Reliant Park & Medical Center
8686 Kirby Drive Houston TX
Free Cancellation
Reserve now, pay when you stay
0.49 mi from South Main
$99 nightly
The price is $116 total per night
$116 total
Nov 9 - Nov 10
Total with taxes and fees
At Wyndham Houston at Reliant Park & Medical Center, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Limited parking is available. Multilingual staff at the front desk are standing by 24/7 to help with concierge services, securing valuables, and luggage storage. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Spa

Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Free Cancellation
Reserve now, pay when you stay
2.71 mi from South Main
$84 nightly
The price is $99 total per night
$99 total
Nov 22 - Nov 23
Total with taxes and fees
Guests staying at Hilton Houston Plaza/Medical Center enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 20 per day. Multilingual staff at the front desk are standing by 24/7 to help with dry cleaning/laundry, concierge services, and securing valuables. Other amenities at this luxury hotel include meeting rooms, conference space, and coffee/tea in a common area.
Pool
Free WiFi

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
2712 Southwest Fwy Houston TX
Free Cancellation
4.05 mi from South Main
$66 nightly
The price is $77 total per night
$77 total
Dec 7 - Dec 8
Total with taxes and fees
Guests of Crowne Plaza Houston Med Ctr-Galleria Area by IHG have access to an outdoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 25.00 per day. The 24-hour front desk has multilingual staff ready to assist with luggage storage, dry cleaning/laundry, and tours or tickets. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Free WiFi

The Royal Sonesta Houston Galleria
2222 West Loop South Houston TX
5.49 mi from South Main
$129 nightly
The price is $151 total per night
$151 total
Nov 22 - Nov 23
Total with taxes and fees
The Royal Sonesta Houston Galleria features an outdoor pool, a 24-hour gym, and meeting rooms. Valet parking is offered for USD 45.00 per night. Multilingual staff at the 24-hour front desk can assist with luggage storage, dry cleaning/laundry, and securing valuables. Additional amenities include a conference center, a 24-hour business center, and coffee/tea in a common area.
Pool
Pet friendly

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
Free Cancellation
Reserve now, pay when you stay
5.5 mi from South Main
$115 nightly
The price is $134 total per night
$134 total
Nov 23 - Nov 24
Total with taxes and fees
At DoubleTree by Hilton Hotel & Suites Houston by the Galleria, guests enjoy features like an outdoor pool, a 24-hour gym, and WiFi in public areas. Parking is available for USD 32 per night (USD 46.00 per night for valet parking), and there's also a free area shuttle. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry and luggage storage. Additional amenities include conference space, a business center, and a seasonal outdoor pool.
Pool
Pet friendly

The Whitehall Houston
1700 Smith St Houston TX
Free Cancellation
Reserve now, pay when you stay
6.2 mi from South Main
$136 nightly
The price is $159 total per night
$159 total
Dec 8 - Dec 9
Total with taxes and fees
At The Whitehall Houston, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 59 per night, and there's also a free area shuttle. The front desk has multilingual staff on hand 24/7 to help with dry cleaning/laundry, luggage storage, and tours or tickets. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include meeting rooms, a conference center, and a 24-hour business center.
Pool
Pet friendly

Club Quarters Hotel Downtown, Houston
1085 Rusk Street Houston TX
Free Cancellation
Reserve now, pay when you stay
6.76 mi from South Main
$81 nightly
The price is $95 total per night
$95 total
Nov 10 - Nov 11
Total with taxes and fees
At Club Quarters Hotel Downtown, Houston, guests have access to a 24-hour gym, free WiFi in public areas, and meeting rooms. Valet parking is offered for USD 45 per day. Multilingual staff at the 24-hour front desk can assist with luggage storage, dry cleaning/laundry, and securing valuables. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a computer station.
Pet friendly
Free WiFi

Grand Tuscany Hotel
12801 Northwest Fwy Houston TX
Free Cancellation
Reserve now, pay when you stay
12.6 mi from South Main
$111 nightly
The price is $130 total per night
$130 total
Dec 9 - Dec 10
Total with taxes and fees
At Grand Tuscany Hotel, guests enjoy features like a lazy river, a gym, and free WiFi in public areas. Valet parking is available for USD 20.00 per day. The 24-hour front desk has multilingual staff ready to help with luggage storage, and answer any questions about the area. Other amenities at this family-friendly hotel include meeting rooms, a conference center, and a seasonal outdoor pool.
Pool
Free WiFi

Hyatt Regency Houston West
13210 Katy Fwy Houston TX
Free Cancellation
Reserve now, pay when you stay
14.38 mi from South Main
$103 nightly
The price is $121 total per night
$121 total
Dec 6 - Dec 7
Total with taxes and fees
At Hyatt Regency Houston West, guests enjoy features like an outdoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking if you drive. The front desk has multilingual staff on hand 24/7 to help with securing valuables, dry cleaning/laundry, and concierge services. Additional amenities include meeting rooms, a conference center, and a business center.
Pool
Pet friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
South Main hotels essential information
Accommodation | 7,382 hotels |
|---|---|
Lowest Price | $77 |
Highest Price | $159 |
Popular hotels | Wyndham Houston at Reliant Park & Medical Center, DoubleTree by Hilton Hotel & Suites Houston by the Galleria, Club Quarters Hotel Downtown, Houston, Hilton Houston Plaza/Medical Center, The Whitehall Houston, The Royal Sonesta Houston Galleria, Hyatt Regency Houston West, Grand Tuscany Hotel, Crowne Plaza Houston Med Ctr-Galleria Area by IHG |
Recent Reviews

Club Quarters Hotel Downtown, Houston
5/5 Excellent
"Clean room and quick check in"
A verified traveler stayed at Club Quarters Hotel Downtown, Houston
Posted 8 hours ago
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