Hotels in Defiance
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Top Rated Defiance Hotels
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive Fenton MO
Free Cancellation
Reserve now, pay when you stay
17.91 mi from city center
$85 nightly
The price is $98 total per night
$98 total
Dec 29 - Dec 30
Total with taxes and fees
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham features an indoor pool, an outdoor pool, and a gym. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and luggage storage. Additional amenities include free WiFi in public areas, a hot tub, and meeting rooms.
Pool
Hot Tub
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Free Cancellation
Reserve now, pay when you stay
18.31 mi from city center
$183 nightly
The price is $214 total per night
$214 total
Dec 29 - Dec 30
Total with taxes and fees
Guests of Ameristar Casino Resort and Spa have access to a full-service spa, a casino, and a 24-hour gym. The 24-hour front desk has multilingual staff ready to assist with luggage storage and concierge services. Other amenities at this luxury hotel include 2 hot tubs, a conference center, and a seasonal outdoor pool.
Pool
Hot Tub
The Wildwood Hotel
2801 Fountain Pl Wildwood MO
Free Cancellation
Reserve now, pay when you stay
8.76 mi from city center
$92 nightly
The price is $108 total per night
$108 total
Jan 8 - Jan 9, 2026
Total with taxes and fees
Guests staying at The Wildwood Hotel enjoy an indoor pool, a gym, and free WiFi in public areas. You can put free parking to good use if you drive. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a hot tub, meeting rooms, and conference space.
Pool
Hot Tub
La Quinta Inn & Suites by Wyndham St. Louis Westport
11805 Lackland Rd Maryland Heights MO
Free Cancellation
Reserve now, pay when you stay
19.04 mi from city center
$82 nightly
The price is $95 total per night
$95 total
Dec 28 - Dec 29
Total with taxes and fees
Guests of La Quinta Inn & Suites by Wyndham St. Louis Westport have access to an outdoor pool, a gym, and free WiFi in public areas. You can take advantage of free parking, along with a free airport shuttle during limited hours. The 24-hour front desk has multilingual staff ready to help with luggage storage, and answer any questions about the area. Additional amenities include conference space, a business center, and coffee/tea in a common area.
Pool
Breakfast included
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
13639 Riverport Dr Maryland Heights MO
Free Cancellation
Reserve now, pay when you stay
18.88 mi from city center
$66 nightly
The price is $77 total per night
$77 total
Jan 6 - Jan 7, 2026
Total with taxes and fees
Guests of Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The 24-hour front desk has staff standing by to help with luggage storage, and answer any questions about the accommodations. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a meeting room.
Pool
Breakfast included
Best Western Plus The Charles Hotel
1425 South 5th Street St. Charles MO
Free Cancellation
Reserve now, pay when you stay
18.08 mi from city center
$88 nightly
The price is $102 total per night
$102 total
Dec 30 - Dec 31
Total with taxes and fees
At Best Western Plus The Charles Hotel, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. Free parking is available if you drive. The 24-hour front desk has multilingual staff ready to assist with luggage storage and dry cleaning/laundry. Additional amenities include meeting rooms, conference space, and a business center.
Pool
Breakfast included
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
Free Cancellation
Reserve now, pay when you stay
18.13 mi from city center
$142 nightly
The price is $166 total per night
$166 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
Guests of Hollywood Casino & Hotel St. Louis have access to a casino, a 24-hour gym, and meeting rooms. You can take advantage of free parking, along with a free airport shuttle at scheduled times. Front-desk staff can answer questions 24/7, and assist with luggage storage, concierge services, and securing valuables. Additional amenities include conference space, a 24-hour business center, and express check-out.
Free airport shuttle
Parking included
Crowne Plaza St. Louis Airport by IHG
11228 Lone Eagle Dr Bridgeton MO
Free Cancellation
21.82 mi from city center
$125 nightly
The price is $148 total per night
$148 total
Jan 22 - Jan 23, 2026
Total with taxes and fees
At Crowne Plaza St. Louis Airport by IHG, guests enjoy an indoor pool, a gym, and free WiFi in public areas. If you drive, self parking is USD 10.00 per night, or you can take advantage of the free airport shuttle (available 24 hours). The front desk is staffed 24/7 to help with luggage storage, dry cleaning/laundry, and concierge services. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Pool
Free airport shuttle
Courtyard by Marriott St Louis Creve Coeur
828 N New Ballas Rd St. Louis MO
Free Cancellation
Reserve now, pay when you stay
18.27 mi from city center
$122 nightly
The price is $142 total per night
$142 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
At Courtyard by Marriott St Louis Creve Coeur, guests have access to a 24-hour gym, free WiFi in public areas, and conference space. A stay here includes free parking. The front desk is staffed 24 hours a day to help with securing valuables and dry cleaning/laundry. Additional amenities include a microwave in a common area, a computer station, and express check-out.
Pet friendly
Parking included
Wingate by Wyndham St. Louis/Fenton Route 66
1100 S Highway Dr Fenton MO
Free Cancellation
Reserve now, pay when you stay
17.88 mi from city center
$79 nightly
The price is $91 total per night
$91 total
Dec 28 - Dec 29
Total with taxes and fees
Wingate by Wyndham St. Louis/Fenton Route 66 features an outdoor pool, free WiFi in public areas, and coffee in a common area. Free parking is available if you drive. The front desk is staffed 24 hours a day to help with luggage storage and securing valuables. Additional amenities include express check-out, a vending machine, and a TV in a common area.
Pool
Breakfast included
Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
Free Cancellation
Reserve now, pay when you stay
16.14 mi from city center
$89 nightly
The price is $103 total per night
$103 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
At Hampton Inn St. Charles St. Peters, guests enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. You can take advantage of free parking if you drive. The 24-hour front desk has staff standing by to help with dry cleaning/laundry and securing valuables. Other amenities at this golf hotel include a hot tub, a 24-hour business center, and coffee/tea in a common area.
Pool
Hot Tub
Relax Inn Saint Charles
3800 Harry S Truman Blvd St. Charles MO
Free Cancellation
16.17 mi from city center
$58 nightly
The price is $67 total per night
$67 total
Dec 28 - Dec 29
Total with taxes and fees
Guests staying at Relax Inn Saint Charles enjoy free WiFi in public areas, laundry facilities, and a vending machine. If you drive, take advantage of free parking. Front-desk staff are standing by 24/7 to assist with any requests.
Parking included
Free WiFi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top reasons to visit Defiance
- Wineries Galore: Defiance is a wine lover's paradise, with nearby wineries offering delightful tastings that will make your taste buds dance.
- Nature's Playground: Get your hiking boots ready and explore the breathtaking natural parks and trails that will leave you in awe of Mother Nature.
- Step Back in Time: History buffs rejoice! Defiance is packed with attractions and historic sites that will transport you to a bygone era.
- Entertainment Extravaganza: From destination activities to outdoor adventures, Defiance offers a wide range of entertainment options to keep you thoroughly entertained.
- A Town for All: Whether you're a wine enthusiast, nature lover, or history buff, Defiance has something for everyone to enjoy. Don't miss out!
Popular hotels in Defiance
Defiance, Missouri, a charming outdoor destination, offers a range of hotel options to suit every traveler's taste and budget. From rustic lodges nestled in the heart of nature to modern hotels with all the amenities, Defiance has something for everyone. Whether you're looking for a luxurious retreat or a budget-friendly stay, you'll find a variety of choices. Don't forget to check out hotel reviews and compare prices to find the best deals and cheap hotels in Defiance, Missouri.
- Clayton Plaza Hotel & Extended Stay - Located 23.9 miles away from Defiance, this 3.5-star hotel offers close proximity to friendly people, arcade, and breakfast. With amenities like free airport transportation, a wedding venue, indoor and outdoor pools, sauna, and university nearby, it is a great option for your outdoor vacation.
- Pear Tree Inn St. Louis Airport - This 2.5-star hotel is located 23.2 miles away from Defiance and provides easy access to friendly people, transportation services, and free airport transportation. It also offers amenities such as connecting rooms, smoking area, fitness center, and sports. Perfect for your outdoor vacation needs.
- Hollywood Casino & Hotel St. Louis - Situated 18.2 miles away from Defiance, this 3.5-star hotel is ideal for outdoor enthusiasts with its close proximity to a casino, live music, and friendly people. Additionally, it offers amenities like rock climbing, access to the river, free airport transportation, and a theater. A great choice for your outdoor vacation.
Top things to see and do in Defiance
Located in the charming town of Defiance, Missouri, there are plenty of activities to keep travelers entertained. Whether you're a wine enthusiast, nature lover, or history buff, Defiance has something for everyone. Explore the nearby wineries and indulge in wine tastings, or take a hike through the picturesque natural parks and trails. For history enthusiasts, there are many attractions and historic places to visit, allowing you to delve into the rich history of the area. From destination activities to a wide range of things to do, Defiance offers a variety of entertainment spots and outdoor activities to keep visitors engaged.
- Chandler Hill Vineyards: Immerse yourself in the beauty of the countryside while sipping on exquisite wines. Enjoy the enchanting atmosphere of the winery, surrounded by picturesque vineyards and rolling hills. Indulge in a romantic dinner at their charming restaurant, or dance the night away at one of their lively events. Friendly staff and a warm ambiance make this a perfect spot for a memorable experience.
- Historic Daniel Boone Home and Heritage Center: Step back in time as you explore the historic home of the legendary pioneer, Daniel Boone. Wander through nature trails that lead to secluded spots, where you can dance under the stars during festivals. Discover the rich culture and heritage of the region, surrounded by beautiful forests and scenic wineries. Engage with friendly locals who are passionate about preserving history and enjoy the tranquility of a nearby lake.
- August A. Busch Memorial Conservation Area: Immerse yourself in nature at this expansive conservation area. Dance through the lush landscapes and witness stunning birdwatching opportunities. Enjoy a friendly game of baseball with your family or dine in the midst of beautiful gardens filled with colorful flowers. Take exciting excursions through the area and marvel at the diverse wildlife. This family-friendly destination offers a perfect blend of outdoor activities and peaceful surroundings.
Seasonal travel trends of Defiance
The popularity of Defiance shows a slight change throughout the year. The most popular time to visit is between July and September, with a seasonal peak in July. The off-peak tourist season is from November and January, with December typically being the quietest month.
Check out the month-by-month weather chart for Defiance to help you plan your next trip. With a monthly average of 79.0 degrees Fahrenheit, you can expect the hottest temperatures in July. The coldest month, on average, is January. The most rainfall typically happens in May. Regardless of when you visit Defiance, every season has a reason to stay.
 Calendar Month |  Temperature |  Precipitation |  Cloudiness |
| January | 31.6°F (-0.2°C) | Light Rain | Mostly Cloudy |
| February | 34.7°F (1.5°C) | Light Rain | Mostly Sunny |
| March | 46.4°F (8.0°C) | Light Rain | Mostly Sunny |
| April | 55.9°F (13.3°C) | Light Rain | Mostly Sunny |
| May | 66.2°F (19.0°C) | Light Rain | Mostly Sunny |
| June | 75.9°F (24.4°C) | Light Rain | Mostly Sunny |
| July | 79.0°F (26.1°C) | Light Rain | Mostly Sunny |
| August | 77.2°F (25.1°C) | Light Rain | Mostly Sunny |
| September | 70.9°F (21.6°C) | Light Rain | Mostly Sunny |
| October | 58.5°F (14.7°C) | Light Rain | Mostly Sunny |
| November | 46.2°F (7.9°C) | Light Rain | Mostly Sunny |
| December | 37.6°F (3.1°C) | Light Rain | Mostly Sunny |
Where should you stay in Defiance?
What are some favorite hotels in Defiance?
Consider these top hotels around Defiance:
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham is located 17.9 mi away, and this hotel has free breakfast, free WiFi, and free parking.
- Hollywood Casino & Hotel St. Louis is located 18.1 mi away, and this hotel has a casino, 7 restaurants, and 3 bars.
- The Wildwood Hotel is located 8.8 mi away, and this hotel has free breakfast, free WiFi, and free parking.
Yellow Farmhouse Winery and Chandler Hill Vineyards are a couple of sights to visit in the heart of Defiance.
Defiance hotels essential information
Accommodation | 865 hotels |
|---|---|
Lowest Price | $67 |
Highest Price | $214 |
Popular hotels | Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, Ameristar Casino Resort and Spa, The Wildwood Hotel, La Quinta Inn & Suites by Wyndham St. Louis Westport, Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West, Best Western Plus The Charles Hotel, Hollywood Casino & Hotel St. Louis, Crowne Plaza St. Louis Airport by IHG, Courtyard by Marriott St Louis Creve Coeur, Wingate by Wyndham St. Louis/Fenton Route 66, Hampton Inn St. Charles St. Peters, Relax Inn Saint Charles |
Booking tips for Defiance
Find your perfect hotel with Orbitz
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Travel as you are
At Orbitz, we believe that travel should be inclusive and enjoyable for everyone. From our early support of LGBTQIA rights to our commitment to creating a more welcoming world, we are here to help you celebrate who you are and where you're going. With our tools, LGBTQIA+ travelers can plan and book with confidence, including a filter to find LGBTQ-welcoming hotels where you'll be celebrated, not just tolerated.
Saving tips for your trip
If you're planning a trip to Defiance, Missouri, try to avoid the peak season from July to September and consider visiting during the off-peak season from November to January. To save money, bundle your flights, hotel, and car bookings together for a discounted price. While exploring Defiance, take advantage of the close proximities to inexpensive attractions such as local wineries, natural parks, and historical sites. These affinities offer affordable and enjoyable experiences for travelers on a budget.
Recent Reviews
Ameristar Casino Resort and Spa
5/5 Excellent
"The room was impeccable and the staff were super friendly. I plan to say in the future."
A verified traveler stayed at Ameristar Casino Resort and Spa
Posted 3 days ago
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