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Featured Uptown 5 Stars Hotels

Graduate by Hilton Cincinnati

Graduate by Hilton Cincinnati

4 out of 5
151 Goodman St Cincinnati OH
Free Cancellation
Reserve now, pay when you stay
0.1 mi from city center
$104 nightly
The price is $124 total per night
$124 total
Dec 16 - Dec 17
Total with taxes and fees
Guests of Graduate by Hilton Cincinnati enjoy a 24-hour gym, free WiFi in public areas, and a conference center. Self parking is available for USD 20.00 per day. The front desk is staffed 24/7 to help with tours or tickets, securing valuables, and luggage storage. Additional amenities include a terrace, wedding services, and a porter/bellhop.
Pet friendly
Free WiFi
Hotel Celare, Cincinnati Midtown, a Tribute Portfolio Hotel

Hotel Celare, Cincinnati Midtown, a Tribute Portfolio Hotel

4 out of 5
310 STRAIGHT STREET CINCINNATI Cincinnati OH
Free Cancellation
Reserve now, pay when you stay
0.97 mi from city center
$129 nightly
The price is $154 total per night
$154 total
Dec 17 - Dec 18
Total with taxes and fees
At Hotel Celare, Cincinnati Midtown, a Tribute Portfolio Hotel, guests have access to free WiFi in public areas, meeting rooms, and a terrace. Valet parking is available for USD 40 per day. The front desk is staffed 24/7 to help with dry cleaning or laundry, and answer any questions about the accommodations. This smoke-free hotel also has a banquet hall.
Pet friendly
Free WiFi
voco The Clair Cincinnati Downtown by IHG

voco The Clair Cincinnati Downtown by IHG

4 out of 5
701 Broadway Street Cincinnati OH
Free Cancellation
2.27 mi from city center
$119 nightly
The price is $142 total per night
$142 total
Dec 7 - Dec 8
Total with taxes and fees
Guests of voco The Clair Cincinnati Downtown by IHG have access to an indoor pool, a 24-hour gym, and free WiFi in public areas. Self parking is available for USD 20 per day. The front desk is staffed 24/7 to help with luggage storage, concierge services, and securing valuables. Additional amenities include laundry facilities and a vending machine.
Pool
Free WiFi
21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

4.5 out of 5
609 Walnut St Cincinnati OH
Free Cancellation
Reserve now, pay when you stay
2.4 mi from city center
$148 nightly
The price is $176 total per night
$176 total
Jan 2 - Jan 3, 2026
Total with taxes and fees
Guests staying at 21c Museum Hotel Cincinnati enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. Valet parking is offered for USD 40.00 per night. Front-desk staff can answer questions 24/7, and assist with concierge services, luggage storage, and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Other amenities at this luxury hotel include a conference center, a 24-hour business center, and a computer station.
Spa
Pet friendly
The Westin Cincinnati

The Westin Cincinnati

4 out of 5
21 E 5th St Cincinnati OH
Free Cancellation
Reserve now, pay when you stay
2.55 mi from city center
$118 nightly
The price is $141 total per night
$141 total
Dec 28 - Dec 29
Total with taxes and fees
Guest of The Westin Cincinnati enjoy features like meeting rooms, conference space, and a business center. Self parking is offered for USD 21 per night. The front desk is staffed 24/7 to help with dry cleaning/laundry, securing valuables, and concierge services. Additional amenities include express check-out, a ballroom, and an ATM.
Hilton Cincinnati Netherland Plaza

Hilton Cincinnati Netherland Plaza

4 out of 5
35 W 5th St Cincinnati OH
Free Cancellation
Reserve now, pay when you stay
2.56 mi from city center
$117 nightly
The price is $140 total per night
$140 total
Dec 25 - Dec 26
Total with taxes and fees
At Hilton Cincinnati Netherland Plaza, guests have access to a 24-hour gym, free WiFi in public areas, and meeting rooms. Valet parking is offered for USD 49.00 per day. The front desk has multilingual staff on hand 24/7 to help with dry cleaning/laundry, securing valuables, and concierge services. Other amenities at this historic hotel include conference space, a business center, and express check-out.
Pet friendly
Free WiFi
Hyatt Regency Cincinnati

Hyatt Regency Cincinnati

4 out of 5
151 West Fifth Street Cincinnati OH
Free Cancellation
Reserve now, pay when you stay
2.59 mi from city center
$152 nightly
The price is $181 total per night
$181 total
Dec 19 - Dec 20
Total with taxes and fees
Guests of Hyatt Regency Cincinnati have access to an indoor pool, a gym, and free WiFi in public areas. Valet parking is offered for USD 49.00 per night. Multilingual staff at the 24-hour front desk can assist with dry cleaning/laundry, securing valuables, and concierge services. Additional amenities include meeting rooms, conference space, and a business center.
Pool
Pet friendly
Hampton Inn & Suites Newport/Cincinnati

Hampton Inn & Suites Newport/Cincinnati

2.5 out of 5
275 Columbia Street Newport KY
Free Cancellation
Reserve now, pay when you stay
3.11 mi from city center
$95 nightly
The price is $107 total per night
$107 total
Dec 21 - Dec 22
Total with taxes and fees
At Hampton Inn & Suites Newport/Cincinnati, guests enjoy features like an indoor pool, a gym, and free WiFi in public areas. Self parking is offered for USD 10.00 per day. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. If you like to take your furry friend along on your adventures, this pet-friendly property offers an off-leash area. Additional amenities include meeting rooms, a business center, and coffee/tea in a common area.
Pool
Breakfast included
LivINN Hotel Cincinnati / Sharonville Convention Center

LivINN Hotel Cincinnati / Sharonville Convention Center

2.5 out of 5
11385 Chester Rd Sharonville OH
Free Cancellation
Reserve now, pay when you stay
10.43 mi from city center
$60 nightly
The price is $72 total per night
$72 total
Dec 4 - Dec 5
Total with taxes and fees
Guests staying at LivINN Hotel Cincinnati / Sharonville Convention Center enjoy an indoor pool, a 24-hour gym, and free WiFi in public areas. A stay here includes free parking. The front desk is staffed 24 hours a day to help with securing valuables and tours/tickets. Additional amenities include conference space, a business center, and coffee/tea in a common area.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Best 5 star hotels in Uptown

Guarantee yourself a relaxing time when you book the best of the best: 5 star hotels in Uptown. After all, treating yourself to the finer things is what vacations are about. 

What are the criteria for a 5 star hotel?
5 star hotel requirements include distinctive services and amenities that surpass all others. These Uptown hotels bring an incomparable degree of quality and attention to detail, with guest satisfaction being top priority. Your 5 star hotel should be dressed to impress, with design details like marble surfaces and hi-tech fixtures.

What amenities can I expect at a 5 star hotel?
Uptown 5 star hotels and resorts typically offer luxury amenities such as:

  • Gourmet restaurant
  • Full-service fitness center with pool
  • Luxury spa 
  • Welcome gifts upon arrival
  • Top-of-the-line beds and linens 
  • Designer personal care products
  • Premium cable, free Wi-Fi and device docking stations

How do I find an amazing 5 star hotel?
Finding 5 star hotel deals in Uptown with Orbitz is as easy as your stay will be. For the top-shelf vacation you deserve, we’ll help you choose the right hotel in the right place: 

  • Search hotels by price, ranging from $72 to $181
  • Find the best-loved hotels through word-of-mouth advice when you check out over reviews by Orbitz travelers
  • Choose from 2,168 5 star hotels in Uptown!

Uptown hotels essential information

Accommodation
2,168 hotels
Lowest Price
$72
Highest Price
$181
Popular hotels
Graduate by Hilton Cincinnati, Hotel Celare, Cincinnati Midtown, a Tribute Portfolio Hotel, Hilton Cincinnati Netherland Plaza, voco The Clair Cincinnati Downtown by IHG, Hyatt Regency Cincinnati, LivINN Hotel Cincinnati / Sharonville Convention Center, 21c Museum Hotel Cincinnati, Hampton Inn & Suites Newport/Cincinnati, The Westin Cincinnati

Recent Reviews

Graduate by Hilton Cincinnati

Graduate by Hilton Cincinnati

5/5 Excellent
"Super friendly lady at check in. Clean, uniquely decorated room. "
A verified traveler stayed at Graduate by Hilton Cincinnati
Posted 21 hours ago
Graduate by Hilton Cincinnati

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