$145 Cheap flight deals from Jacksonville (JAX) to Des Moines (SEA)

Orbitz guarantees you low prices on flights from Jacksonville to Des Moines. In addition to low fares on Jacksonville to Des Moines flights, Orbitz offers fantastic savings on hotels, cruises, vacation packages, and more.

Earn Miles While Saving

Besides helping you fly for the lowest fares, Orbitz lets you earn miles for your frequent flyer program for certain flights from Jacksonville to Des Moines. If you are a member of the frequent flyer or loyalty program offered by the airline you booked through Orbitz or a partner airline’s, simply add your frequent flyer number to your Orbitz reservation to get credit for your Jacksonville to Des Moines flights.

Travel Planning Made Easy

We help take some of the anxiety out of your Jacksonville to Des Moines flights with free flight alerts. We will let you know of flight changes and delays to your flights from Jacksonville to Des Moines by email, voicemail, or text messages to your mobile phone. Alerts can also be sent to up to six other contacts to keep family and business teams informed.

Use Mobile Apps with Orbitz

Orbitz lets you find the best deals on Jacksonville to Des Moines flights while on the go, with our easy-to-use Android and iPhone mobile apps. Easily check flight status, gate numbers, and other flight details all in one place with our app—which is great when you are in a hurry. You can use the apps to access great mobile deals on flights and amazing hotel rooms.