$163 Cheap flight deals from Myrtle Beach (MYR) to Knoxville (TYS)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Myrtle Beach to Knoxville

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Dec 20 - Tue, Dec 23
MYR
Myrtle Beach Intl.
TYS
McGhee Tyson
$499 Roundtrip, found 1 day ago
$499
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 20 from Myrtle Beach Intl. to McGhee Tyson, returning Tue, Dec 23, priced at $499 found 1 day ago

Airfares from $163 One Way, $308 Round Trip from Myrtle Beach to Knoxville

Prices starting at $308 for return flights and $163 for one-way flights to Knoxville were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jan 21 - Wed, Jan 28
MYR
Myrtle Beach
TYS
Knoxville
$308 Roundtrip, found 3 days ago
$308
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jan 21 from Myrtle Beach to Knoxville, returning Wed, Jan 28, priced at $308 found 3 days ago
Wed, Jan 21 - Tue, Jan 27
MYR
Myrtle Beach
TYS
Knoxville
$311 Roundtrip, found 3 days ago
$311
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jan 21 from Myrtle Beach to Knoxville, returning Tue, Jan 27, priced at $311 found 3 days ago
Wed, Jan 21 - Sat, Jan 24
MYR
Myrtle Beach
TYS
Knoxville
$316 Roundtrip, found 3 days ago
$316
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jan 21 from Myrtle Beach to Knoxville, returning Sat, Jan 24, priced at $316 found 3 days ago
Thu, Jan 22 - Sun, Jan 25
MYR
Myrtle Beach
TYS
Knoxville
$322 Roundtrip, found 3 days ago
$322
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jan 22 from Myrtle Beach to Knoxville, returning Sun, Jan 25, priced at $322 found 3 days ago
Thu, Jan 22 - Sun, Jan 25
MYR
Myrtle Beach
TYS
Knoxville
$325 Roundtrip, found 3 days ago
$325
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jan 22 from Myrtle Beach to Knoxville, returning Sun, Jan 25, priced at $325 found 3 days ago

More About Flying To Knoxville from Myrtle Beach

Route Information for Flights from Myrtle Beach to Knoxville

Origin Airport IATA Code
MYR
Destination Airport IATA Code
TYS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Myrtle Beach to Knoxville

For the best available deals on flights from Myrtle Beach to Knoxville, look no further than Orbitz. Offering the perfect packages with cutting-edge mobile tools, Orbitz is your ideal destination.

One Stop Travel Shop

Not only is Orbitz the best source for great deals on flights from Myrtle Beach to Knoxville, we offer the complete package. From guaranteed low prices on hotels, car rentals and activities, simply decide what you want and Orbitz will put together the complete vacation package.

Searching Anywhere

Booking Myrtle Beach to Knoxville flights is simple, wherever you are. Book on your computer and the Orbitz Display Matrix gives all your deals and discounts on flights from Myrtle Beach to Knoxville, showing your great savings. Or if you are on the move, use m.orbitz.com on your mobile browser to find exclusive Myrtle Beach to Knoxville flights for mobile users.

Worry-free Travel Planning

Orbitz is the best place for Myrtle Beach to Knoxville flights at guaranteed low prices, we also take the stress out of your flight details. With our free alerts service you can quickly find out your gate number or flight delays via email or text – perfect if you are in a rush.

Miles Better

If you frequently travel on flights from Myrtle Beach to Knoxville, it’s easy to rack up your air miles. Just add your frequent flyer number when booking your flights and we will do the rest. Orbitz will even store your number in your profile to automatically add on your miles each time you book.

Frequently asked questions

What is the shortest flight from Myrtle Beach to Knoxville?
It can take as little as 2 hours and 3 minutes to get from Myrtle Beach Intl. Airport to Knoxville Airport. Kick back and enjoy the trip, because you'll be coming in to land in the blink of an eye.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.