
$137 Cheap flight deals from Santo Domingo (SDQ) to Medellín (MDE)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Santo Domingo to Medellín
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $137 One Way, $281 Round Trip from Santo Domingo to Medellín
Prices starting at $281 for return flights and $137 for one-way flights to Medellín were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Medellín economy flight packages

Örök Landscape Hotel
Dec 18 - Dec 22
Santo Domingo (SDQ) to Medellín (MDE)
Reviewed on Nov 6, 2026

Revellion by EP
Dec 26 - Dec 30
Santo Domingo (SDQ) to Medellín (MDE)
Reviewed on Sep 8, 2026

Medellín business class flight packages

Golden Valley Hotel
Dec 30 - Jan 3
Santo Domingo (SDQ) to Medellín (MDE)
Medellín (MDE) to Santo Domingo (SDQ)

Hotel Du Parc
Dec 30 - Jan 3
Santo Domingo (SDQ) to Medellín (MDE)
Medellín (MDE) to Santo Domingo (SDQ)

The Anti Galerie Hotel
Dec 30 - Jan 3
Santo Domingo (SDQ) to Medellín (MDE)
Medellín (MDE) to Santo Domingo (SDQ)
More About Flying To Medellín from Santo Domingo
Route Information for Flights from Santo Domingo to Medellín
Origin Airport IATA Code | SDQ |
|---|---|
Destination Airport IATA Code | MDE |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Santo Domingo to Medellín
Searching for deals for cheap flights from Santo Domingo to Medellín? Orbitz has your guaranteed low prices and offers cutting-edge mobile tools to make it easy to find bargain air tickets.
Use Orbitz Apps to Find Santo Domingo to Medellín Flights
Smartphone users can download the Orbitz app for Android and iPhone devices to get information on low fare deals for flights from Santo Domingo to Medellín anytime. These apps allow users to not only book tickets but check on their flight status and get the details they need to find the right departure gate—right on their mobile device.
Earn Miles on Your Cheap Flight
Orbitz makes it simple to earn points for your frequent flyer program when you book certain flights from Santo Domingo to Medellín. Just enter the account number associated with your frequent flyer program during the booking process, and your points or miles will be added after you complete your flight.
Orbitz Flight Alerts Keep You Updated
Along with offering bargain prices for Santo Domingo to Medellín flights, Orbitz also features free flight alerts that inform you of any abrupt changes to your travel itinerary. You can opt to have your alerts sent by email, voice, or text message. Orbitz will even forward the alerts to your contacts, who may need to adjust their plans for picking you up at the terminal.
Get Bargain Fares for Santo Domingo to Medellín Flights
Orbitz makes it quick and easy to find airfare sales and low fare tickets. Decide which airline and flight times you want or, if your schedule is flexible, choose a range of dates to see the best prices.
Frequently asked questions
- Flights to Medellín
- Flights from Santo Domingo
- Santo Domingo Airports
- Medellín Airports
- Airlines Operating
Flights to Medellín
- New York to Medellín
- Toronto to Medellín
- Los Angeles to Medellín
- Houston to Medellín
- Orlando to Medellín
- San Francisco to Medellín
- Chicago to Medellín
- Bogotá to Medellín
- Montreal to Medellín
- Pereira to Medellín
- Barranquilla to Medellín
- São Paulo to Medellín
- Bucaramanga to Medellín
- Buenos Aires to Medellín
Flights from Santo Domingo
- Santo Domingo to New York
- Santo Domingo to Toronto
- Santo Domingo to Orlando
- Santo Domingo to Montreal
- Santo Domingo to Washington
- Santo Domingo to Dallas
- Santo Domingo to Madrid
- Santo Domingo to San Francisco
- Santo Domingo to São Paulo
- Santo Domingo to Chicago
- Santo Domingo to Paris
- Santo Domingo to Columbus
- Santo Domingo to London
- Santo Domingo to Rome
- Santo Domingo to Milan
- Santo Domingo to Atlantic City
- Santo Domingo to Málaga
Santo Domingo Airports
Medellín Airports
More Destinations
- Cabin Rentals in Rionegro
- Rionegro Hotels
- Villas in Rionegro
- Hotels near Botero Plaza
- Cabin Rentals in Guarne
- Guarne Hotels
- Hotels near Arvi Park
- Apartments in Sabaneta
- Condo Rentals in Sabaneta
- Cottages in Sabaneta
- Sabaneta Hotels
- San Javier Hotels
- Spa Resorts & in Laureles
- Hotels near Hospital Pablo Tobon Uribe
- Hotels near Piedras Blancas Ecological Park
- Marinilla Hotels
- Amaga Hotels
- San Diego Hotels
- Hotels near Hospital Universitario San Vicente de Paul
- Hotels near Golden Mile
- Business Hotels in Antioquia
- Kid Friendly Hotels in Antioquia
- Hotels with Hot Tubs in Antioquia
- Pet Friendly Hotels in Antioquia
- Spa Resorts & in Antioquia
- Hotels with a Wedding Venue in Antioquia
- Antioquia Hotels
- Hotels near Llanogrande Mall
- San Antonio de Prado Hotels
- Hotels with Free Airport Shuttle in Medellín
- Cottages in Itagüí
- Extended Stay Hotels in Itagüí
- Itagüí Hotels
- Extended Stay Hotels in San Antonio de Pereira
- San Antonio de Pereira Hotels
- Hotels near Explora Park
- El Rosario Hotels
- Girardota Hotels
- Hotels near Lleras Park
- Apartments in Bello
- Farmstay in Retiro
- Retiro Hotels
- Manrique Hotels
- Cheap Hotels in El Poblado
- Kid Friendly Hotels in El Poblado
- Gay Friendly Hotels in El Poblado
- Hotels with Balconies in El Poblado
- Hotels with an Indoor Pool in El Poblado
- Hotels with a Wedding Venue in El Poblado
- El Poblado Hotels
- La Candelaria Hotels
- Condo Rentals in Envigado
- Guest Houses in Envigado
- Envigado Hotels
- Cabin Rentals in San Jerónimo
- San Jerónimo Hotels
- Villas in San Jerónimo
- Extended Stay Hotels in Santa Elena
- Hotels near José María Córdova Intl.
- Hotels near Atanasio Giradot Stadium
- Estadio Hotels
- Hotels near Medellín Clinic - El Poblado
- Flights to Rionegro
- Flights from New York to Rionegro
- Flights from Rionegro
- Flights from Bogotá to Guatapé
- Flights from Buenos Aires to Guatapé
- Flights from Dallas to Guatapé
- Flights from Minneapolis - St. Paul to Guatapé
- Flights from St. Louis to Guatapé
- Flights from Fort Lauderdale to Guatapé
- Flights from Tampa to Guatapé
- Flights from Cali to Guatapé
- Flights to Antioquia
- Flights from Itagüí
- Flights from Bello
- Flights from Envigado
- Flights from Santa Elena
- Flights from José María Córdova Intl.
- Flights from Bogotá (BOG) to Medellín (MDE)
- Flights from New York (JFK) to Medellín (MDE)
- Flights from Los Angeles (LAX) to Medellín (MDE)
- Flights from Miami (MIA) to Medellín (MDE)
- Car rental Rionegro
- Car rental Sabaneta
- Car rentals near Antioquia
- Car rentals near Plaza Cisneros
- Alamo Rent A Car Rental Cars in José María Córdova Intl.
- Avis Rental Cars in José María Córdova Intl.
- Budget Rental Cars in José María Córdova Intl.
- Dollar Rent A Car Rental Cars in José María Córdova Intl.
- Enterprise Rental Cars in José María Córdova Intl.
- Europcar Rental Cars in José María Córdova Intl.
- Fox Rental Cars Rental Cars in José María Córdova Intl.
- Hertz Rental Cars in José María Córdova Intl.
- Payless Rental Cars in José María Córdova Intl.
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
