$98 Cheap flight deals from Santo Domingo (SDQ) to Medellin (MDE)

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This Weekend's Flight Deals from Santo Domingo to Medellin

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Nov 15 - Sat, Nov 22
SDQ
Las Americas Intl.
MDE
José María Córdova Intl.
$341 Roundtrip, found 12 hours ago
$341
Roundtrip
found 12 hours ago
Select avianca flight, departing Sat, Nov 15 from Las Americas Intl. to José María Córdova Intl., returning Sat, Nov 22, priced at $341 found 12 hours ago

Airfares from $98 One Way, $210 Round Trip from Santo Domingo to Medellin

Prices starting at $210 for return flights and $98 for one-way flights to Medellin were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Mar 5 - Tue, Mar 10
SDQ
Santo Domingo
MDE
Medellin
$210 Roundtrip, found 1 hour ago
$210
Roundtrip
found 1 hour ago
Select Arajet flight, departing Thu, Mar 5 from Santo Domingo to Medellin, returning Tue, Mar 10, priced at $210 found 1 hour ago
Wed, Jan 21 - Thu, Jan 22
SDQ
Santo Domingo
MDE
Medellin
$229 Roundtrip, found 1 hour ago
$229
Roundtrip
found 1 hour ago
Select Arajet flight, departing Wed, Jan 21 from Santo Domingo to Medellin, returning Thu, Jan 22, priced at $229 found 1 hour ago
Sun, Jan 11 - Thu, Jan 15
SDQ
Santo Domingo
MDE
Medellin
$237 Roundtrip, found 2 hours ago
$237
Roundtrip
found 2 hours ago
Select Arajet flight, departing Sun, Jan 11 from Santo Domingo to Medellin, returning Thu, Jan 15, priced at $237 found 2 hours ago
Sat, Jan 17 - Sat, Jan 24
SDQ
Santo Domingo
MDE
Medellin
$246 Roundtrip, just found
$246
Roundtrip
just found
Select Arajet flight, departing Sat, Jan 17 from Santo Domingo to Medellin, returning Sat, Jan 24, priced at $246 just found
Wed, Dec 3 - Wed, Dec 10
SDQ
Santo Domingo
MDE
Medellin
$339 Roundtrip, found 12 hours ago
$339
Roundtrip
found 12 hours ago
Select avianca flight, departing Wed, Dec 3 from Santo Domingo to Medellin, returning Wed, Dec 10, priced at $339 found 12 hours ago

Medellin economy flight packages

Price found within the past 48 hours. Click for updated prices.
Blues Suites Medellin
4.0-star property

Blues Suites Medellin

9/10 Wonderful! (943 reviews)

Dec 26 - Dec 29

3 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Price was $836, price is now $580 per person
$580
per person
found 1 day ago
Perfect location, excellent staff! Will definitely stay again here!

Reviewed on Sep 20, 2025

Sonata 44 Hotel Laureles
3.0-star property

Sonata 44 Hotel Laureles

9/10 Wonderful! (54 reviews)

Dec 31 - Jan 8

8 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Save 100% on your flight
Price was $1,232, price is now $613 per person
$613
per person
found 18 hours ago
The rooms are in great condition. Depending on overall room usage the pressure of the hot water may be limited at certain times of the day. Complementary breakfast great. Roof top restaurant very good, but remember to separate space by reservation.

Reviewed on Jul 6, 2025

Urbit Social Lofts
3.0-star property

Urbit Social Lofts

9.2/10 Wonderful! (314 reviews)

Dec 31 - Jan 8

8 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Save 100% on your flight
Price was $1,198, price is now $698 per person
$698
per person
found 18 hours ago
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More About Flying To Medellin from Santo Domingo

Route Information for Flights from Santo Domingo to Medellin

Origin Airport IATA Code
SDQ
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Santo Domingo to Medellin

It has never been easier to find cheap Santo Domingo to Medellin flights. Orbitz has some of the best deals around to save you more money on your flight, hotel, and vacation package for the trip you have been waiting for.

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Pile Up Miles With Discount Air Tickets

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Stay on top of the latest updates for flights from Santo Domingo to Medellin. We send you free email and mobile alerts to keep you informed about delays to Santo Domingo to Medellin flights.

Frequently asked questions

What is the shortest flight from Santo Domingo to Medellin?
The fastest flight time from Santo Domingo to Medellin is 3 hours and 35 minutes, which gives you lots of time to enjoy a beverage or get swept up in a good movie.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.