$96 Cheap flight deals from Santo Domingo (SDQ) to Medellin (MDE)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Santo Domingo to Medellin
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $96 One Way, $227 Round Trip from Santo Domingo to Medellin
Prices starting at $227 for return flights and $96 for one-way flights to Medellin were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Medellin economy flight packages
Aparta Suites Torre Poblado
Mar 27 - Mar 31
Santo Domingo (SDQ) to Medellín (MDE)
Medellín (MDE) to Santo Domingo (SDQ)
Reviewed on Jun 12, 2023
The Charlee Hotel
Mar 26 - Mar 31
Santo Domingo (SDQ) to Medellín (MDE)
Medellín (MDE) to Santo Domingo (SDQ)
Reviewed on Nov 3, 2025
Hotel Park 10
Apr 6 - Apr 12
Santo Domingo (SDQ) to Medellín (MDE)
Reviewed on Oct 27, 2025
More About Flying To Medellin from Santo Domingo
Route Information for Flights from Santo Domingo to Medellin
Origin Airport IATA Code | SDQ |
|---|---|
Destination Airport IATA Code | MDE |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Santo Domingo to Medellin
Find bargain tickets for flights from Santo Domingo to Medellin, and plan your whole trip in just minutes with Orbitz. With Orbitz’s guaranteed low fares, there is no need to wait for special sales to find deals.
Cheap Flights From Santo Domingo to Medellin Through Orbitz
You need a vacation but you have a tight budget, and searching for discount Santo Domingo to Medellin flights has become an exercise in frustration. It's time to stop combing through never-ending search engine results, and go straight to Orbitz.
Guaranteed Low Fares for Santo Domingo to Medellin Flights
Whether you are looking for domestic or international flights, Orbitz offers you the lowest price. With our low price guarantee on flights from Santo Domingo to Medellin, you know you are getting the best deal out there.
Frequent Flyer Miles and Points on Your Flights From Santo Domingo to Medellin
Not only will you pay a low fare through Orbitz, but you can also get credit for frequent flyer miles or points. All you have to do is add your frequent flyer number in the appropriate field when you book Santo Domingo to Medellin flights that qualify.
Arrange Flights From Santo Domingo to Medellin Cutting-Edge Mobile Tools
We know you are busy, so with our mobile apps for Android and iOS devices, you can search for flights, book your seats, and make cancellations while standing in line or in a waiting room. You can also find great discounts on hotel rooms and vacation packages that go with your Santo Domingo to Medellin flights.
Frequently asked questions
- Flights to Medellin
- Flights from Santo Domingo
- Santo Domingo Airports
- Medellin Airports
- Airlines Operating
Flights to Medellin
- New York to Medellin
- Pereira to Medellin
- Bogotá to Medellin
- Buenos Aires to Medellin
- Chicago to Medellin
- Houston to Medellin
- Los Angeles to Medellin
- Montreal to Medellin
- Orlando to Medellin
- San Francisco to Medellin
- Toronto to Medellin
- Sao Paulo to Medellin
- Barranquilla to Medellin
- Bucaramanga to Medellin
Flights from Santo Domingo
- Santo Domingo to Chicago
- Santo Domingo to New York
- Santo Domingo to Orlando
- Santo Domingo to Toronto
- Santo Domingo to Paris
- Santo Domingo to Columbus
- Santo Domingo to Dallas
- Santo Domingo to London
- Santo Domingo to Madrid
- Santo Domingo to Montreal
- Santo Domingo to San Francisco
- Santo Domingo to Washington
- Santo Domingo to Rome
- Santo Domingo to Milan
- Santo Domingo to Sao Paulo
- Santo Domingo to Atlantic City
- Santo Domingo to Málaga
Santo Domingo Airports
Medellin Airports
More Destinations
- Cabin Rentals in Rionegro
- Rionegro Hotels
- Villas in Rionegro
- Hotels near Botero Plaza
- Cabin Rentals in Guarne
- Guarne Hotels
- Hotels near Arvi Park
- Apartments in Sabaneta
- Condo Rentals in Sabaneta
- Cottages in Sabaneta
- Sabaneta Hotels
- San Javier Hotels
- Spa Resorts & in Laureles
- Hotels near Hospital Pablo Tobon Uribe
- Hotels near Piedras Blancas Ecological Park
- Marinilla Hotels
- Amaga Hotels
- San Diego Hotels
- Hotels near Hospital Universitario San Vicente de Paul
- Hotels near Golden Mile
- Business Hotels in Antioquia
- Kid Friendly Hotels in Antioquia
- Hotels with Hot Tubs in Antioquia
- Pet Friendly Hotels in Antioquia
- Spa Resorts & in Antioquia
- Hotels with a Wedding Venue in Antioquia
- Antioquia Hotels
- Hotels near Llanogrande Mall
- San Antonio de Prado Hotels
- Hotels with Free Airport Shuttle in Medellín
- Cottages in Itagüí
- Extended Stay Hotels in Itagüí
- Itagüí Hotels
- Extended Stay Hotels in San Antonio de Pereira
- San Antonio de Pereira Hotels
- Hotels near Explora Park
- El Rosario Hotels
- Girardota Hotels
- Hotels near Lleras Park
- Apartments in Bello
- Farmstay in Retiro
- Retiro Hotels
- Manrique Hotels
- Cheap Hotels in El Poblado
- Kid Friendly Hotels in El Poblado
- Gay Friendly Hotels in El Poblado
- Hotels with Balconies in El Poblado
- Hotels with an Indoor Pool in El Poblado
- Hotels with a Wedding Venue in El Poblado
- El Poblado Hotels
- La Candelaria Hotels
- Condo Rentals in Envigado
- Guest Houses in Envigado
- Envigado Hotels
- Cabin Rentals in San Jerónimo
- San Jerónimo Hotels
- Villas in San Jerónimo
- Extended Stay Hotels in Santa Elena
- Hotels near José María Córdova Intl.
- Hotels near Atanasio Giradot Stadium
- Estadio Hotels
- Hotels near Medellín Clinic - El Poblado
- Flights to Rionegro
- Flights from New York to Rionegro
- Flights from Rionegro
- Flights from Bogotá to Guatapé
- Flights from Buenos Aires to Guatapé
- Flights from Dallas to Guatapé
- Flights from Minneapolis - St. Paul to Guatapé
- Flights from St. Louis to Guatapé
- Flights from Fort Lauderdale to Guatapé
- Flights from Tampa to Guatapé
- Flights from Cali to Guatapé
- Flights to Antioquia
- Flights from Itagüí
- Flights from Bello
- Flights from Envigado
- Flights from Santa Elena
- Flights from José María Córdova Intl.
- Flights from Bogotá (BOG) to Medellín (MDE)
- Flights from New York (JFK) to Medellín (MDE)
- Flights from Los Angeles (LAX) to Medellín (MDE)
- Flights from Miami (MIA) to Medellín (MDE)
- Car rental Rionegro
- Car rental Sabaneta
- Car rentals near Antioquia
- Car rentals near Plaza Cisneros
- Alamo Rent A Car Rental Cars in José María Córdova Intl.
- Avis Rental Cars in José María Córdova Intl.
- Budget Rental Cars in José María Córdova Intl.
- Dollar Rent A Car Rental Cars in José María Córdova Intl.
- Enterprise Rental Cars in José María Córdova Intl.
- Europcar Rental Cars in José María Córdova Intl.
- Fox Rental Cars Rental Cars in José María Córdova Intl.
- Hertz Rental Cars in José María Córdova Intl.
- Payless Rental Cars in José María Córdova Intl.
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.