
$142 Cheap flight deals from St. Louis (STL) to Medellin (MDE)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
Airfares from $142 One Way, $393 Round Trip from St. Louis to Medellin
Prices starting at $393 for return flights and $142 for one-way flights to Medellin were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Medellin economy flight packages

Hotel Los Recuerdos
Dec 22 - Dec 28
St. Louis (STL) to Medellín (MDE)
Medellín (MDE) to St. Louis (STL)
Reviewed on Sep 6, 2021

Blues Suites Medellin
Dec 22 - Dec 28
St. Louis (STL) to Medellín (MDE)
Medellín (MDE) to St. Louis (STL)
Reviewed on Sep 20, 2025

Hotel Park 10
Dec 22 - Dec 28
St. Louis (STL) to Medellín (MDE)
Medellín (MDE) to St. Louis (STL)
Reviewed on Oct 27, 2025
More About Flying To Medellin from St. Louis
Route Information for Flights from St. Louis to Medellin
Origin Airport IATA Code | STL |
|---|---|
Destination Airport IATA Code | MDE |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
St. Louis to Medellin
Find bargain tickets for flights from St. Louis to Medellin, and plan your whole trip in just minutes with Orbitz. With Orbitz’s guaranteed low fares, there is no need to wait for special sales to find deals.
Cheap Flights From St. Louis to Medellin Through Orbitz
You need a vacation but you have a tight budget, and searching for discount St. Louis to Medellin flights has become an exercise in frustration. It's time to stop combing through never-ending search engine results, and go straight to Orbitz.
Guaranteed Low Fares for St. Louis to Medellin Flights
Whether you are looking for domestic or international flights, Orbitz offers you the lowest price. With our low price guarantee on flights from St. Louis to Medellin, you know you are getting the best deal out there.
Frequent Flyer Miles and Points on Your Flights From St. Louis to Medellin
Not only will you pay a low fare through Orbitz, but you can also get credit for frequent flyer miles or points. All you have to do is add your frequent flyer number in the appropriate field when you book St. Louis to Medellin flights that qualify.
Arrange Flights From St. Louis to Medellin Cutting-Edge Mobile Tools
We know you are busy, so with our mobile apps for Android and iOS devices, you can search for flights, book your seats, and make cancellations while standing in line or in a waiting room. You can also find great discounts on hotel rooms and vacation packages that go with your St. Louis to Medellin flights.
Frequently asked questions
Flights to Medellin
- New York to Medellin
- Los Angeles to Medellin
- Orlando to Medellin
- Toronto to Medellin
- Bogotá to Medellin
- Houston to Medellin
- Chicago to Medellin
- Montreal to Medellin
- San Francisco to Medellin
- Pereira to Medellin
- Barranquilla to Medellin
- Buenos Aires to Medellin
- Sao Paulo to Medellin
- Bucaramanga to Medellin
Flights from St. Louis
- St. Louis to Orlando
- St. Louis to New York
- St. Louis to Houston
- St. Louis to Dallas
- St. Louis to Chicago
- St. Louis to Denver
- St. Louis to Atlanta
- St. Louis to Phoenix
- St. Louis to Los Angeles
- St. Louis to New Orleans
- St. Louis to Toronto
- St. Louis to Detroit
- St. Louis to Washington
- St. Louis to Kansas City
- St. Louis to London
- St. Louis to Cleveland
- St. Louis to San Francisco
- St. Louis to Rome
- St. Louis to Montreal
- St. Louis to Vancouver
St. Louis Airports
Medellin Airports
More Destinations
- Business Hotels in Antioquia
- Kid Friendly Hotels in Antioquia
- Hotels with Hot Tubs in Antioquia
- Pet Friendly Hotels in Antioquia
- Spa Resorts & in Antioquia
- Hotels with a Wedding Venue in Antioquia
- Antioquia Hotels
- Hotels near Explora Park
- Amaga Hotels
- Cottages in Itagüí
- Extended Stay Hotels in Itagüí
- Itagüí Hotels
- Girardota Hotels
- San Diego Hotels
- Spa Resorts & in Laureles
- Cabin Rentals in Guarne
- Guarne Hotels
- Hotels near Piedras Blancas Ecological Park
- Marinilla Hotels
- Manrique Hotels
- Cabin Rentals in San Jerónimo
- San Jerónimo Hotels
- Villas in San Jerónimo
- Apartments in Bello
- Farmstay in Retiro
- Retiro Hotels
- San Javier Hotels
- Condo Rentals in Envigado
- Guest Houses in Envigado
- Envigado Hotels
- Hotels near Arvi Park
- Hotels near Golden Mile
- Cabin Rentals in Rionegro
- Rionegro Hotels
- Villas in Rionegro
- Hotels near Botero Plaza
- La Candelaria Hotels
- Hotels near Hospital Universitario San Vicente de Paul
- San Antonio de Prado Hotels
- Hotels with Free Airport Shuttle in Medellín
- Hotels near Hospital Pablo Tobon Uribe
- Hotels near Atanasio Giradot Stadium
- Cheap Hotels in El Poblado
- Kid Friendly Hotels in El Poblado
- Gay Friendly Hotels in El Poblado
- Hotels with Balconies in El Poblado
- Hotels with an Indoor Pool in El Poblado
- Hotels with a Wedding Venue in El Poblado
- El Poblado Hotels
- Hotels near Medellín Clinic - El Poblado
- Hotels near Lleras Park
- Extended Stay Hotels in Santa Elena
- Hotels near José María Córdova Intl.
- Estadio Hotels
- El Rosario Hotels
- Hotels near Llanogrande Mall
- Extended Stay Hotels in San Antonio de Pereira
- San Antonio de Pereira Hotels
- Apartments in Sabaneta
- Condo Rentals in Sabaneta
- Cottages in Sabaneta
- Sabaneta Hotels
- Flights to Antioquia
- Flights from Itagüí
- Flights from Bello
- Flights from Envigado
- Flights to Rionegro
- Flights from New York to Rionegro
- Flights from Rionegro
- Flights from Bogotá to Guatapé
- Flights from Buenos Aires to Guatapé
- Flights from Dallas to Guatapé
- Flights from Minneapolis - St. Paul to Guatapé
- Flights from St. Louis to Guatapé
- Flights from Fort Lauderdale to Guatapé
- Flights from Tampa to Guatapé
- Flights from Cali to Guatapé
- Flights from Santa Elena
- Flights from José María Córdova Intl.
- Flights from Bogotá (BOG) to Medellín (MDE)
- Flights from New York (JFK) to Medellín (MDE)
- Flights from Los Angeles (LAX) to Medellín (MDE)
- Flights from Miami (MIA) to Medellín (MDE)
- Car rentals near Antioquia
- Car rental Rionegro
- Car rentals near Plaza Cisneros
- Alamo Rent A Car Rental Cars in José María Córdova Intl.
- Avis Rental Cars in José María Córdova Intl.
- Budget Rental Cars in José María Córdova Intl.
- Dollar Rent A Car Rental Cars in José María Córdova Intl.
- Enterprise Rental Cars in José María Córdova Intl.
- Europcar Rental Cars in José María Córdova Intl.
- Fox Rental Cars Rental Cars in José María Córdova Intl.
- Hertz Rental Cars in José María Córdova Intl.
- Payless Rental Cars in José María Córdova Intl.
- Car rental Sabaneta
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.

