$106 Cheap flight deals from Columbus (CMH) to Lower Keys (EYW)

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This Weekend's Flight Deals from Columbus to Lower Keys

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Jan 25 - Wed, Feb 4
CMH
John Glenn Columbus Intl.
EYW
Key West Intl.
$280 Roundtrip, found 5 days ago
$280
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Jan 25 from John Glenn Columbus Intl. to Key West Intl., returning Wed, Feb 4, priced at $280 found 5 days ago

Airfares from $106 One Way, $209 Round Trip from Columbus to Lower Keys

Prices starting at $209 for return flights and $106 for one-way flights to Lower Keys were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Feb 23 - Thu, Feb 26
CMH
Columbus
EYW
Key West
$209 Roundtrip, found 1 day ago
$209
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Mon, Feb 23 from Columbus to Key West, returning Thu, Feb 26, priced at $209 found 1 day ago
Mon, Feb 16 - Thu, Feb 19
CMH
Columbus
EYW
Key West
$211 Roundtrip, found 1 day ago
$211
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Mon, Feb 16 from Columbus to Key West, returning Thu, Feb 19, priced at $211 found 1 day ago
Thu, Feb 5 - Thu, Feb 19
CMH
Columbus
EYW
Key West
$212 Roundtrip, found 6 days ago
$212
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Thu, Feb 5 from Columbus to Key West, returning Thu, Feb 19, priced at $212 found 6 days ago
Sun, Feb 15 - Thu, Feb 19
CMH
Columbus
EYW
Key West
$226 Roundtrip, found 2 days ago
$226
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Sun, Feb 15 from Columbus to Key West, returning Thu, Feb 19, priced at $226 found 2 days ago
Sun, Feb 22 - Thu, Feb 26
CMH
Columbus
EYW
Key West
$227 Roundtrip, found 2 days ago
$227
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Sun, Feb 22 from Columbus to Key West, returning Thu, Feb 26, priced at $227 found 2 days ago

Lower Keys economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hyatt Vacation Club at Beach House, Key West
3.5-star property

Hyatt Vacation Club at Beach House, Key West

9.4/10 Exceptional! (1,002 reviews)

Mar 9 - Mar 13

4 night stay

Columbus (CMH) to Key West (EYW)

Spirit Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,611, price is now $1,051 per person
$1,051
per person
found 1 day ago
The property was truly amazing. We.rented a 2 bedroom villa and it was comfortable and very well decorated and equipped. The only complaint would be the " complimentary breakfast" needs to be better. It was only a selection of cruisants with water and orange juice. For the price spent, please add eggs, meat and coffee at least. Other than that, it was very nice

Reviewed on Sep 7, 2025

The Key West Hotel
2.5-star property

The Key West Hotel

9.2/10 Wonderful! (505 reviews)

Feb 25 - Feb 28

3 night stay

Columbus (CMH) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $2,743, price is now $1,697 per person
$1,697
per person
found 1 day ago
Gorgeous property right on Duval Street but hidden from the noise and bustle. Convenient to everything you want to do and see. Wonderfully helpful and friendly staff.

Reviewed on Jan 5, 2025

Lighthouse Hotel - Key West Historic Inns
3.5-star property

Lighthouse Hotel - Key West Historic Inns

9/10 Wonderful! (831 reviews)

Feb 25 - Feb 28

3 night stay

Columbus (CMH) to Key West (EYW)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,993, price is now $1,370 per person
$1,370
per person
found 1 day ago
The rooms ideally could have been a bit cleaner. For instance vacuum underneath the furnishings. Great breakfast and the loft room Was fantastic. Close to everything yet not in the congestion.

Reviewed on Jan 15, 2026

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Lower Keys packages with premium economy flights

Price found within the past 48 hours. Click for updated prices.
Oceans Edge Key West Resort, Hotel & Marina
4.0-star property

Oceans Edge Key West Resort, Hotel & Marina

9/10 Wonderful! (1,736 reviews)

Feb 22 - Feb 25

3 night stay

Columbus (CMH) to Key West (EYW)

Delta • Non-stop roundtrip • PremiumEconomy
Price was $1,487, price is now $1,008 per person
$1,008
per person
found 1 day ago
We LOVED the setting and the surrounding area! Absolutely beautiful! Be aware the hotel IS in the airport landing zone. If you like to watch/hear commercial planes you'll be very happy. Ask for a room on the top floor only - so you can (1) look over the marina AND (2) so you won't hear people moving chairs on their balcony above you. The max/min air conditioning is centrally controlled. If you want it colder than 67, you will not be able to. Not sure what the max heat was. Be extra vigilant about putting a thick towel on the floor to soak up any water that gets past the shower door. It WILL happen! Please do not slip on the wet tile floor! Be aware that if you want/need a later checkout, they will charge you an additional $50/hour past their usual checkout time of 11am. Be prepared for onsite meal expenses. They are very good, but they ARE on the pricy side. Our particular room smelled strongly of smoke on arrival. I'm nearly POSITIVE we asked for a nonsmoking room as we both have underlying medical problems that preclude exposre to smoke. Perhaps call ahead to ENSURE you get a nonsmoking on arrival. The entire hotel was booked so we did not have any other choice.

Reviewed on Dec 28, 2025

The Key West Hotel
2.5-star property

The Key West Hotel

9.2/10 Wonderful! (505 reviews)

Feb 22 - Feb 25

3 night stay

Columbus (CMH) to Key West (EYW)

Delta • Non-stop roundtrip • PremiumEconomy
Save 100% on your flight
Price was $2,700, price is now $1,557 per person
$1,557
per person
found 1 day ago
Gorgeous property right on Duval Street but hidden from the noise and bustle. Convenient to everything you want to do and see. Wonderfully helpful and friendly staff.

Reviewed on Jan 5, 2025

Blue Flamingo Resort Key West
4.0-star property

Blue Flamingo Resort Key West

8/10 Very Good! (1,693 reviews)

Feb 22 - Feb 25

3 night stay

Columbus (CMH) to Key West (EYW)

Delta • Non-stop roundtrip • PremiumEconomy
Price was $1,610, price is now $1,163 per person
$1,163
per person
found 1 day ago
The Blue Flamingo is an amazing a GEM in Key West, the location and property are simply fabulous, every employee always with a smile, cant mention all but will state Mr. Jose (Ambassador), Leidy, Irina, Skiff, David and all Waiters and Bartenders go over and beyond to make your stay memorable, Lobby and Reception, housekeepers, pool boys, all friendly and helpful. We will be back many times!

Reviewed on Nov 25, 2025

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More About Flying To Lower Keys from Columbus

Route Information for Flights from Columbus to Lower Keys

Origin Airport IATA Code
CMH
Destination Airport IATA Code
EYW
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Columbus to Lower Keys

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.