Unfortunately, no. You'll have to change planes if you want to fly from Brussels Airport (BRU-Brussels - National) to Charlotte, NC Airport (CLT-Charlotte-Douglas Intl.). A number of airlines service this route with only one stopover, including United Airlines, Lufthansa and Delta Air Lines.
It's a long way between Brussels and Charlotte — in fact, 9 hours and 39 minutes at least. But your time on board doesn't have to be torturous. Be prepared and pack the basics like a sweater and earplugs.
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