Cheap flights from STL to ROA (Lambert-St. Louis Intl. to Roanoke Regional)

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Cheap Flights from STL to ROA starting at $249 One Way, $269 Round Trip

Prices starting at $269 for return flights and $249 for one-way flights to Roanoke Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Feb 13 - Tue, Feb 24
STL
St. Louis
ROA
Roanoke
$269 Roundtrip, found 5 days ago
$269
Roundtrip
found 5 days ago
Select Delta flight, departing Fri, Feb 13 from St. Louis to Roanoke, returning Tue, Feb 24, priced at $269 found 5 days ago
Thu, Feb 5 - Mon, Feb 9
STL
St. Louis
ROA
Roanoke
$276 Roundtrip, found 2 days ago
$276
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Feb 5 from St. Louis to Roanoke, returning Mon, Feb 9, priced at $276 found 2 days ago
Sat, Apr 18 - Tue, Apr 21
STL
St. Louis
ROA
Roanoke
$289 Roundtrip, found 2 days ago
$289
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Apr 18 from St. Louis to Roanoke, returning Tue, Apr 21, priced at $289 found 2 days ago
Fri, Feb 20 - Tue, Feb 24
STL
St. Louis
ROA
Roanoke
$292 Roundtrip, found 2 days ago
$292
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Feb 20 from St. Louis to Roanoke, returning Tue, Feb 24, priced at $292 found 2 days ago
Fri, Feb 20 - Sat, Feb 21
STL
St. Louis
ROA
Roanoke
$296 Roundtrip, found 2 days ago
$296
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Feb 20 from St. Louis to Roanoke, returning Sat, Feb 21, priced at $296 found 2 days ago

Hotel Ideas near Roanoke Regional

Airport Hotels near Roanoke Regional

Spark by Hilton Roanoke Airport

Spark by Hilton Roanoke Airport

2 out of 5
3695 Thirlane Rd Nw Roanoke VA
$77 nightly
The price is $87 total per night from Jan 20 to Jan 21
$87 total
Jan 20 - Jan 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and a free airport shuttle. Popular attractions Valley View Mall and ...
8.8/10 Excellent! (261 reviews)
The stay was wonderful. Staff was great. The room was so clean. And it was so close to the airport and not noisy at all. I will be back for sure!

Reviewed on Jan 6, 2026

Spark by Hilton Roanoke Airport
Country Inn & Suites by Radisson, Roanoke, VA

Country Inn & Suites by Radisson, Roanoke, VA

3 out of 5
7860 Plantation Rd Roanoke VA
$83 nightly
The price is $93 total per night from Feb 8 to Feb 9
$93 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (2,067 reviews)
Clean rooms and great breakfast

Reviewed on Jan 12, 2026

Country Inn & Suites by Radisson, Roanoke, VA
Hyatt Place Roanoke Airport/Valley View Mall

Hyatt Place Roanoke Airport/Valley View Mall

3 out of 5
5040 Valley View Blvd North Roanoke VA
$101 nightly
The price is $114 total per night from Jan 25 to Jan 26
$114 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,000 reviews)
Good

Reviewed on Jan 7, 2026

Hyatt Place Roanoke Airport/Valley View Mall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Roanoke

Country Inn & Suites by Radisson, Roanoke, VA

Country Inn & Suites by Radisson, Roanoke, VA

3 out of 5
7860 Plantation Rd Roanoke VA
$83 nightly
The price is $93 total per night from Feb 8 to Feb 9
$93 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (2,067 reviews)
Clean rooms and great breakfast

Reviewed on Jan 12, 2026

Country Inn & Suites by Radisson, Roanoke, VA
Tru By Hilton Roanoke Hollins

Tru By Hilton Roanoke Hollins

2.5 out of 5
8161 Gander Way Roanoke VA
$88 nightly
The price is $99 total per night from Jan 21 to Jan 22
$99 total
Jan 21 - Jan 22
Total with taxes and fees
Stay at this hotel in Roanoke. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,002 reviews)
Check in was quick and my room was clean. This hotel has an impressive gym and a pool table in the lobby. Complimentary coffee and tea is nice too. Especially after driving all day.

Reviewed on Jan 8, 2026

Tru By Hilton Roanoke Hollins
Hotel Roanoke & Conference Ctr, Curio Collection by Hilton 

Hotel Roanoke & Conference Ctr, Curio Collection by Hilton 

4 out of 5
110 Shenandoah Ave Ne Roanoke VA
$171 nightly
The price is $194 total per night from Jan 25 to Jan 26
$194 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this luxury hotel in Roanoke. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
9.4/10 Exceptional! (1,000 reviews)
Room was clean and the staff made sure my wife and myself were taken care of.

Reviewed on Jan 6, 2026

Hotel Roanoke & Conference Ctr, Curio Collection by Hilton 
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Roanoke Hotels With Airport Transportation

Quality Inn Roanoke Airport

Quality Inn Roanoke Airport

2.5 out of 5
6626 Thirlane Rd Roanoke VA
$80 nightly
The price is $90 total per night from Jan 18 to Jan 19
$90 total
Jan 18 - Jan 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,001 reviews)
Nothing fancy, but clean.

Reviewed on Dec 6, 2025

Quality Inn Roanoke Airport
Spark by Hilton Roanoke Airport

Spark by Hilton Roanoke Airport

2 out of 5
3695 Thirlane Rd Nw Roanoke VA
$77 nightly
The price is $87 total per night from Jan 20 to Jan 21
$87 total
Jan 20 - Jan 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and a free airport shuttle. Popular attractions Valley View Mall and ...
8.8/10 Excellent! (261 reviews)
The stay was wonderful. Staff was great. The room was so clean. And it was so close to the airport and not noisy at all. I will be back for sure!

Reviewed on Jan 6, 2026

Spark by Hilton Roanoke Airport
Baymont by Wyndham Salem Roanoke Area

Baymont by Wyndham Salem Roanoke Area

2.5 out of 5
179 Sheraton Drive Salem VA
$63 nightly
The price is $71 total per night from Jan 29 to Jan 30
$71 total
Jan 29 - Jan 30
Total with taxes and fees
Book a stay at this business-friendly motel in Salem. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.2/10 Good! (329 reviews)
Yes yes

Reviewed on Dec 31, 2025

Baymont by Wyndham Salem Roanoke Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Roanoke Hotels

Travelodge by Wyndham Roanoke

Travelodge by Wyndham Roanoke

2 out of 5
6621 Thirlane Rd Roanoke VA
$54 nightly
The price is $61 total per night from Feb 4 to Feb 5
$61 total
Feb 4 - Feb 5
Total with taxes and fees
Stay at this hotel in Roanoke. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Splash Valley at Green Ridge Recreation Center and AMF ...
5.6/10 (999 reviews)
Yes it was good

Reviewed on Dec 20, 2025

Travelodge by Wyndham Roanoke
Howard Johnson Hotel & Conference Center by Wyndham Salem

Howard Johnson Hotel & Conference Center by Wyndham Salem

2 out of 5
1671 Skyview Rd Salem VA
$58 nightly
The price is $65 total per night from Jan 23 to Jan 24
$65 total
Jan 23 - Jan 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Salem. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Green Hill Park Trailhead and Moyers ...
5.8/10 (1,001 reviews)
The room was clean and the staff is very courteous and helpful.

Reviewed on Jan 4, 2026

Howard Johnson Hotel & Conference Center by Wyndham Salem
Spark by Hilton Daleville Roanoke North

Spark by Hilton Daleville Roanoke North

2 out of 5
446 Roanoke Rd Daleville VA
$65 nightly
The price is $73 total per night from Jan 20 to Jan 21
$73 total
Jan 20 - Jan 21
Total with taxes and fees
Book a stay at this business-friendly hotel in Daleville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,001 reviews)
Clean room, bathroom was clean

Reviewed on Jan 8, 2026

Spark by Hilton Daleville Roanoke North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Roanoke

Country Inn & Suites by Radisson, Roanoke, VA

Country Inn & Suites by Radisson, Roanoke, VA

3 out of 5
7860 Plantation Rd Roanoke VA
$83 nightly
The price is $93 total per night from Feb 8 to Feb 9
$93 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (2,067 reviews)
Clean rooms and great breakfast

Reviewed on Jan 12, 2026

Country Inn & Suites by Radisson, Roanoke, VA
Hyatt Place Roanoke Airport/Valley View Mall

Hyatt Place Roanoke Airport/Valley View Mall

3 out of 5
5040 Valley View Blvd North Roanoke VA
$101 nightly
The price is $114 total per night from Jan 25 to Jan 26
$114 total
Jan 25 - Jan 26
Total with taxes and fees
Book a stay at this business-friendly hotel in Roanoke. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,000 reviews)
Good

Reviewed on Jan 7, 2026

Hyatt Place Roanoke Airport/Valley View Mall
PEAK FALL COLORS NOW-BERNARDS LANDING-BEST AMENITIES INDOOR POOL HOT TUB-OPEN

PEAK FALL COLORS NOW-BERNARDS LANDING-BEST AMENITIES INDOOR POOL HOT TUB-OPEN

Moneta VA
Stay at this condo in Moneta. Enjoy free WiFi, a fitness center, and laundry facilities. Popular attractions Smith Mountain Lake and Pelican Point Yacht Club ...
9.2/10 Wonderful! (146 reviews)
Beautiful view, nice walk out to the lake! Relaxing and quiet.

Reviewed on Sep 26, 2025

Get rates
PEAK FALL COLORS NOW-BERNARDS LANDING-BEST AMENITIES INDOOR POOL HOT TUB-OPEN
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

STL to ROA Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date

Frequently asked questions

Are there non-stop flights from Lambert-St. Louis Intl. Airport (STL) to Roanoke Regional Airport (ROA)?
As you can't fly directly from STL to ROA, a flight with one stopover is the next best thing. American Airlines, United Airlines and Delta Air Lines are all reputable airlines that service this route.
What is the shortest flight from St. Louis Lambert International Airport to ROA?
Take the opportunity to unwind on the flight from St. Louis to Roanoke. The shortest flight time from St. Louis Lambert International Airport to ROA is 3 hours and 35 minutes, which gives you more than enough time to enjoy a red wine or get swept up in a good movie.
How many hours flight from Lambert Field to ROA?
Typically, the flight time from St. Louis Lambert International Airport to Roanoke–Blacksburg Regional Airport takes 3 hours and 41 minutes. If you want to be as comfortable as possible, consider upgrading your seat using miles or cash.
What airlines have the most flights from St. Louis Lambert International Airport to ROA?
Do a little shopping, tuck into some takeaway, strike up a conversation with a stranger ... Airport stopovers don't have to irritating! If you're heading from STL to ROA, you won't find any direct flights. Prepare for at least one stopover somewhere.

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.