$222 Cheap flight deals from Santiago de los Caballeros (POP) to Medellin (MDE)

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You can have total confidence in Orbitz to help you find spectacular deals on Santiago de los Caballeros to Medellin flights at bargain prices. We also display quality accommodations at unbelievable rates, leaving you with spare cash for a little extra indulgence in Medellin.

Mix flights for a perfect schedule

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If value is what you are after, let Orbitz take care of you. Your low cost Santiago de los Caballeros to Medellin flights along with our great bargains on hotels and car rentals will make your trip all the more memorable.