$125 Cheap flight deals from Santo Domingo (SDQ) to Medellín (MDE)

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This Weekend's Flight Deals from Santo Domingo to Medellín

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Aug 23 - Sat, Aug 29
SDQ
Las Americas Intl.
MDE
José María Córdova Intl.
$277 Roundtrip, found 16 hours ago
$277
Roundtrip
found 16 hours ago
Select Arajet flight, departing Sun, Aug 23 from Las Americas Intl. to José María Córdova Intl., returning Sat, Aug 29, priced at $277 found 16 hours ago

Airfares from $125 One Way, $256 Round Trip from Santo Domingo to Medellín

Prices starting at $256 for return flights and $125 for one-way flights to Medellín were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Nov 10 - Tue, Nov 17
SDQ
Santo Domingo
MDE
Medellín
$256 Roundtrip, just found
$256
Roundtrip
just found
Select Arajet flight, departing Tue, Nov 10 from Santo Domingo to Medellín, returning Tue, Nov 17, priced at $256 just found
Tue, Nov 10 - Tue, Nov 17
SDQ
Santo Domingo
MDE
Medellín
$264 Roundtrip, just found
$264
Roundtrip
just found
Select Arajet flight, departing Tue, Nov 10 from Santo Domingo to Medellín, returning Tue, Nov 17, priced at $264 just found
Wed, Sep 9 - Fri, Sep 11
SDQ
Santo Domingo
MDE
Medellín
$269 Roundtrip, found 3 hours ago
$269
Roundtrip
found 3 hours ago
Select Arajet flight, departing Wed, Sep 9 from Santo Domingo to Medellín, returning Fri, Sep 11, priced at $269 found 3 hours ago
Fri, Oct 23 - Mon, Oct 26
SDQ
Santo Domingo
MDE
Medellín
$272 Roundtrip, found 1 hour ago
$272
Roundtrip
found 1 hour ago
Select Arajet flight, departing Fri, Oct 23 from Santo Domingo to Medellín, returning Mon, Oct 26, priced at $272 found 1 hour ago
Fri, Oct 23 - Mon, Oct 26
SDQ
Santo Domingo
MDE
Medellín
$277 Roundtrip, found 1 hour ago
$277
Roundtrip
found 1 hour ago
Select Arajet flight, departing Fri, Oct 23 from Santo Domingo to Medellín, returning Mon, Oct 26, priced at $277 found 1 hour ago

Medellín economy flight packages

Price found within the past 48 hours. Click for updated prices.
Blues Suites Medellin
4.0-star property

Blues Suites Medellin

9/10 Wonderful! (1,288 reviews)

Oct 7 - Oct 12

5 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Price was $990, price is now $601 per person
$601
per person
found 1 day ago
Excelente ubicación y facilidades del hotel! Buen servicio y habitación muy linda y espaciosa

Reviewed on Aug 16, 2026

Autenthico Sajonia Hotel Aeropuerto
2.0-star property

Autenthico Sajonia Hotel Aeropuerto

9.2/10 Wonderful! (88 reviews)

Oct 8 - Oct 13

5 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Avianca • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,352, price is now $714 per person
$714
per person
found 1 day ago
Zero for communication - called multiple times, no answer. Emailed returning their email, no response. They are in a difficult location, and being so close to airport, no taxis want to take you there and at night try and rip you off. Got there, no working water. No air conditioning, no fans, no offer of water bottles or anything else. Went for breakfast after few hours sleep, not even milk for coffee or other basic items. Everyone kept asking how stay was, told them and they smiled and just walked off. 11am checkout sucks for late night arrivals typical of MDE airport. And the probable owner doing Tai Chi at entrance and taking no interest in customer issues was off putting. Not good for business travel. Pity, beautiful venue. Great I guess if you’re looking for a hostel.

Reviewed on Aug 17, 2026

Medellin Marriott Hotel
5.0-star property

Medellin Marriott Hotel

8.8/10 Excellent! (630 reviews)

Oct 3 - Oct 9

6 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Save 100% on your flight
Price was $1,380, price is now $811 per person
$811
per person
found 1 day ago
Excellent breakfast buffet

Reviewed on Aug 13, 2026

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More About Flying To Medellín from Santo Domingo

Route Information for Flights from Santo Domingo to Medellín

Origin Airport IATA Code
SDQ
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Santo Domingo to Medellín

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Frequently asked questions

What is the shortest flight from Santo Domingo to Medellin?
The fastest flight time from Santo Domingo to Medellin is 3 hours and 35 minutes, which gives you lots of time to enjoy a beverage or get swept up in a good movie.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.