$125 Cheap flight deals from Santo Domingo (SDQ) to Medellín (MDE)

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This Weekend's Flight Deals from Santo Domingo to Medellín

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jul 11 - Tue, Jul 14
SDQ
Las Americas Intl.
MDE
José María Córdova Intl.
$295 Roundtrip, found 9 hours ago
$295
Roundtrip
found 9 hours ago
Select Arajet flight, departing Sat, Jul 11 from Las Americas Intl. to José María Córdova Intl., returning Tue, Jul 14, priced at $295 found 9 hours ago

Airfares from $125 One Way, $253 Round Trip from Santo Domingo to Medellín

Prices starting at $253 for return flights and $125 for one-way flights to Medellín were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Jul 28 - Sat, Aug 1
SDQ
Santo Domingo
MDE
Medellín
$253 Roundtrip, just found
$253
Roundtrip
just found
Select Arajet flight, departing Tue, Jul 28 from Santo Domingo to Medellín, returning Sat, Aug 1, priced at $253 just found
Sat, Aug 22 - Tue, Aug 25
SDQ
Santo Domingo
MDE
Medellín
$261 Roundtrip, just found
$261
Roundtrip
just found
Select Arajet flight, departing Sat, Aug 22 from Santo Domingo to Medellín, returning Tue, Aug 25, priced at $261 just found
Wed, Jul 15 - Wed, Aug 19
SDQ
Santo Domingo
MDE
Medellín
$265 Roundtrip, found 3 days ago
$265
Roundtrip
found 3 days ago
Select Arajet flight, departing Wed, Jul 15 from Santo Domingo to Medellín, returning Wed, Aug 19, priced at $265 found 3 days ago
Thu, Jul 30 - Tue, Aug 4
SDQ
Santo Domingo
MDE
Medellín
$269 Roundtrip, found 14 hours ago
$269
Roundtrip
found 14 hours ago
Select Arajet flight, departing Thu, Jul 30 from Santo Domingo to Medellín, returning Tue, Aug 4, priced at $269 found 14 hours ago
Tue, Jul 14 - Wed, Jul 29
SDQ
Santo Domingo
MDE
Medellín
$270 Roundtrip, found 23 hours ago
$270
Roundtrip
found 23 hours ago
Select Arajet flight, departing Tue, Jul 14 from Santo Domingo to Medellín, returning Wed, Jul 29, priced at $270 found 23 hours ago

Medellín economy flight packages

Price found within the past 48 hours. Click for updated prices.
Aparta Suites Torre Poblado
3.0-star property

Aparta Suites Torre Poblado

8.8/10 Excellent! (914 reviews)

Aug 13 - Aug 18

5 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Save 100% on your flight
Price was $787, price is now $449 per person
$449
per person
found 1 day ago
El Hotel es excelente, excepto muy incomodo el papel higiénico... es una tontería... pero también es importante

Reviewed on Jul 2, 2026

The Charlee Hotel
5.0-star property

The Charlee Hotel

8.8/10 Excellent! (1,003 reviews)

Aug 18 - Aug 22

4 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Save 100% on your flight
Price was $1,142, price is now $585 per person
$585
per person
found 1 day ago
The staff there were top tier… beautiful rooms! Very accommodating! And the breakfast was amazing, the egg omelette especially. I will be returning to The Charlee Hotel Medellín on my next visit!

Reviewed on Jul 6, 2026

Devú
5.0-star property

Devú

10/10 Exceptional! (12 reviews)

Aug 18 - Aug 22

4 night stay

Santo Domingo (SDQ) to Medellín (MDE)

Sterling Blue • Roundtrip • Coach
Save 100% on your flight
Price was $1,120, price is now $588 per person
$588
per person
found 1 day ago
I stayed at Devú Hotel for nine nights, and it exceeded my expectations. My room was beautifully designed, quiet, and incredibly comfortable. The service throughout my stay was exceptional. A special thank you to Mateo, the manager, who went above and beyond to make me feel welcome. He and the entire team made me feel right at home from the moment I arrived. I highly recommend Devú Hotel to anyone visiting Medellín and will absolutely stay here again on my next trip.

Reviewed on Jun 30, 2026

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More About Flying To Medellín from Santo Domingo

Route Information for Flights from Santo Domingo to Medellín

Origin Airport IATA Code
SDQ
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Santo Domingo to Medellín

Grab great fares on Santo Domingo to Medellín flights with Orbitz, your #1 source for discount international and domestic air tickets. Our cutting-edge mobile tools and great online search functionality make booking your next budget trip a breeze.

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Frequently asked questions

What is the shortest flight from Santo Domingo to Medellin?
The fastest flight time from Santo Domingo to Medellin is 3 hours and 35 minutes, which gives you lots of time to enjoy a beverage or get swept up in a good movie.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.