$99 Cheap flight deals from St. Louis (STL) to Isle of Palms (CHS)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from St. Louis to Isle of Palms

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Feb 15 - Sat, Feb 21
STL
Lambert-St. Louis Intl.
CHS
Charleston Intl.
$360 Roundtrip, found 6 days ago
$360
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Feb 15 from Lambert-St. Louis Intl. to Charleston Intl., returning Sat, Feb 21, priced at $360 found 6 days ago

Airfares from $99 One Way, $197 Round Trip from St. Louis to Isle of Palms

Prices starting at $197 for return flights and $99 for one-way flights to Isle of Palms were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, May 28 - Sun, May 31
STL
St. Louis
CHS
Charleston
$197 Roundtrip, found 1 hour ago
$197
Roundtrip
found 1 hour ago
Select Delta flight, departing Thu, May 28 from St. Louis to Charleston, returning Sun, May 31, priced at $197 found 1 hour ago
Wed, May 6 - Sat, May 9
STL
St. Louis
CHS
Charleston
$198 Roundtrip, found 22 hours ago
$198
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Wed, May 6 from St. Louis to Charleston, returning Sat, May 9, priced at $198 found 22 hours ago
Mon, Mar 30 - Tue, Mar 31
STL
St. Louis
CHS
Charleston
$201 Roundtrip, found 3 hours ago
$201
Roundtrip
found 3 hours ago
Select Delta flight, departing Mon, Mar 30 from St. Louis to Charleston, returning Tue, Mar 31, priced at $201 found 3 hours ago
Tue, Mar 24 - Tue, Mar 31
STL
St. Louis
CHS
Charleston
$203 Roundtrip, found 3 hours ago
$203
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Mar 24 from St. Louis to Charleston, returning Tue, Mar 31, priced at $203 found 3 hours ago
Tue, Mar 3 - Sat, Mar 7
STL
St. Louis
CHS
Charleston
$204 Roundtrip, found 2 days ago
$204
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Mar 3 from St. Louis to Charleston, returning Sat, Mar 7, priced at $204 found 2 days ago

Isle of Palms economy flight packages

Price found within the past 48 hours. Click for updated prices.
The Francis Marion Hotel
4.0-star property

The Francis Marion Hotel

9/10 Wonderful! (1,942 reviews)

Mar 23 - Mar 27

4 night stay

St. Louis (STL) to Charleston (CHS)

Delta • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $996, price is now $742 per person
$742
per person
found 1 day ago
My sister and I stayed here for our trip to Charleston and this hotel did not disappoint. You get exactly what you’re looking for, a historic hotel within walking distance, a beautiful lobby and interior with updated rooms but still having that old charm to it. The room was spacious with 2 large closets and a full length mirror (very much appreciated by my sister and I) The bathroom was smaller but to be expected with older hotels, the only downfall was the plumbing. The water pressure wasn’t the greatest so made for longer showers and the toilets didn’t flush well. But the hotel is in a perfect area. We flew in and didn't have personal transportation and were able to walk all over for great shopping, restaurants and sites. If we decide to return for another trip to Charleston we would definitely stay here again. We didn’t get a chance to try the restaurant in the hotel but it’s very convenient to have as well as a coffee shop.

Reviewed on Oct 28, 2025

The Ryder Hotel
3.5-star property

The Ryder Hotel

8.6/10 Excellent! (1,002 reviews)

Mar 14 - Mar 17

3 night stay

St. Louis (STL) to Charleston (CHS)

Southwest Airlines • Coach

Charleston (CHS) to St. Louis (STL)

Delta • Coach
Price was $1,190, price is now $893 per person
$893
per person
found 14 hours ago
Love this hotel for the clean room, really great staff and the bar and pool area.

Reviewed on May 11, 2025

Planters Inn
4.5-star property

Planters Inn

9.6/10 Exceptional! (1,004 reviews)

Mar 23 - Mar 27

4 night stay

St. Louis (STL) to Charleston (CHS)

Delta • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,453, price is now $1,112 per person
$1,112
per person
found 1 day ago
Hair on bath floors and building smelled musty…

Reviewed on Oct 15, 2025

Don't see what you're looking for?
See all available trips from St. Louis to Isle of Palms
View all trips

More About Flying To Isle of Palms from St. Louis

Route Information for Flights from St. Louis to Isle of Palms

Origin Airport IATA Code
STL
Destination Airport IATA Code
CHS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

St. Louis to Isle of Palms

Rack up your savings with low-cost flights from St. Louis to Isle of Palms with Orbitz On-the-Go. Orbitz On-the-Go offers mobile-only deals and cutting edge mobile tools to help you find bargain flights from St. Louis to Isle of Palms.

Mobile-Only Deals on St. Louis to Isle of Palms flights

Find guaranteed low prices on St. Louis to Isle of Palms flights using Orbitz On-the-Go. You can book discount domestic flights from St. Louis to Isle of Palms, and international tickets on St. Louis to Isle of Palms flights using our mobile site and apps.

Free Alerts Are No Surprise

Not only will you find cheap tickets on flights from St. Louis to Isle of Palms, but Orbitz free alerts will keep you up to speed on flight status, plus gate and baggage claim details. Receive instant updates via your choice of email, voice or text. Orbitz keeps you easily on task and on budget.

Share Itineraries on Flights from St. Louis to Isle of Palms

Are you traveling for business, pleasure or a combination of both? Keep family, friends and business contacts posted on flight and gate info. Just use MyTrips for iPhone, Android and web phones like Blackberry and Windows.

Add Smiles to Your Miles with Sales and Deals on St. Louis to Isle of Palms Flights

Travel planning is easy when you store your frequent flyer and loyalty program information on your Orbitz account. Then snag a low-fare air ticket on St. Louis to Isle of Palms flights, and you’re done. No muss, no fuss. Your miles will fly by with Orbitz On-the-Go cutting edge mobile tools and guaranteed low prices.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.