$188 Cheap flight deals from Guayaquil (GYE) to Panama City (PTY)

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This Weekend's Flight Deals from Guayaquil to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jan 2 - Mon, Jan 5
GYE
Jose Joaquin de Olmedo Intl.
PTY
Tocumen Intl.
$478 Roundtrip, found 1 day ago
$478
Roundtrip
found 1 day ago
Select Copa flight, departing Fri, Jan 2 from Jose Joaquin de Olmedo Intl. to Tocumen Intl., returning Mon, Jan 5, priced at $478 found 1 day ago

Airfares from $188 One Way, $335 Round Trip from Guayaquil to Panama City

Prices starting at $335 for return flights and $188 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jan 30 - Wed, Feb 4
GYE
Guayaquil
PTY
Panama City
$335 Roundtrip, found 2 hours ago
$335
Roundtrip
found 2 hours ago
Select Copa flight, departing Fri, Jan 30 from Guayaquil to Panama City, returning Wed, Feb 4, priced at $335 found 2 hours ago
Mon, Apr 13 - Mon, Apr 20
GYE
Guayaquil
PTY
Panama City
$347 Roundtrip, found 5 days ago
$347
Roundtrip
found 5 days ago
Select avianca flight, departing Mon, Apr 13 from Guayaquil to Panama City, returning Mon, Apr 20, priced at $347 found 5 days ago
Fri, Jan 30 - Wed, Feb 4
GYE
Guayaquil
PTY
Panama City
$354 Roundtrip, found 2 hours ago
$354
Roundtrip
found 2 hours ago
Select avianca flight, departing Fri, Jan 30 from Guayaquil to Panama City, returning Wed, Feb 4, priced at $354 found 2 hours ago
Tue, Jan 27 - Fri, Jan 30
GYE
Guayaquil
PTY
Panama City
$359 Roundtrip, found 5 days ago
$359
Roundtrip
found 5 days ago
Select avianca flight, departing Tue, Jan 27 from Guayaquil to Panama City, returning Fri, Jan 30, priced at $359 found 5 days ago
Sun, Mar 1 - Sat, Mar 7
GYE
Guayaquil
PTY
Panama City
$361 Roundtrip, found 5 days ago
$361
Roundtrip
found 5 days ago
Select avianca flight, departing Sun, Mar 1 from Guayaquil to Panama City, returning Sat, Mar 7, priced at $361 found 5 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites
2.0-star property

Mahogany Suites

10/10 Exceptional! (1 review)

Feb 1 - Feb 4

3 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $624, price is now $410 per person
$410
per person
found 1 day ago
Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9/10 Wonderful! (1,002 reviews)

Jan 28 - Jan 31

3 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,118, price is now $722 per person
$722
per person
found 1 day ago
Kimberly at the Front Desk was wonderful!

Reviewed on Jun 8, 2025

Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (1,204 reviews)

Jan 28 - Jan 31

3 night stay

Guayaquil (GYE) to Panama City (PTY)

Copa • Roundtrip • Coach
Price was $951, price is now $664 per person
$664
per person
found 1 day ago
Room was very clean, breakfast was great.Easy check in.

Reviewed on Nov 16, 2025

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More About Flying To Panama City from Guayaquil

Route Information for Flights from Guayaquil to Panama City

Origin Airport IATA Code
GYE
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Guayaquil to Panama City

It has never been easier to find cheap Guayaquil to Panama City flights. Orbitz has some of the best deals around to save you more money on your flight, hotel, and vacation package for the trip you have been waiting for.

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Get the Best Deals on Guayaquil to Panama City Flights

Finding great deals on flights from Guayaquil to Panama City is a snap with Orbitz. With our guaranteed low prices, you don’t have to worry if you are getting the best prices on air tickets, hotels, and cruises. And with all that money you saved, you can enjoy your Panama City vacation even more.

Pile Up Miles With Discount Air Tickets

Not only can you find great bargains on Guayaquil to Panama City flights, but you can rack up frequent flyer miles on the flights too. Enter your frequent flyer number on qualified flights when booking for Orbitz to see the miles pile up in your account.

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Frequently asked questions

Are there non-stop flights from Guayaquil to Panama City?
Work out your ideal travel dates, because there is. You can fly from Airport of Guayaquil to Panama City (PTY-Tocumen Intl.) in one simple journey with Copa Airlines.
What is the shortest flight from Guayaquil to Panama City?
Leave that movie marathon for some other time, because the journey from Guayaquil to Panama City can take as little as 2 hours and 6 minutes.
What airlines fly from Guayaquil to Panama City most frequently?
Copa Airlines has the most flights along this route. This popular airline operates 152 flights from Guayaquil to Panama City each month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.