Hotels in Isle of Palms

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Featured Hotels in Isle of Palms

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3 out of 5
4905 SAN PABLO ROAD SOUTH Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
1.27 mi from Isle of Palms
$175 nightly
The price is $199 total per night
$199 total
Feb 6 - Feb 7
Total with taxes and fees
At Residence Inn By Marriott Jacksonville - Mayo Clinic Area, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff on hand 24/7 to help with luggage storage, concierge services, and dry cleaning/laundry. Additional amenities include conference space, a 24-hour business center, and coffee/tea in a common area.
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

2.5 out of 5
715 1st St N Jacksonville Beach FL
Free Cancellation
Reserve now, pay when you stay
2.84 mi from Isle of Palms
$149 nightly
The price is $169 total per night
$169 total
Feb 2 - Feb 3
Total with taxes and fees
Margaritaville Jacksonville Beach features karaoke, an outdoor pool, and a gym. Valet parking is available for USD 27.00 per day. The front desk is staffed 24/7 to help secure valuables, and answer any questions about the accommodations. Other amenities at this beach hotel include free WiFi in public areas, meeting rooms, and a 24-hour business center.
Wyndham Garden Jacksonville

Wyndham Garden Jacksonville

3 out of 5
4660 Salisbury Road Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
9.65 mi from Isle of Palms
$74 nightly
The price is $84 total per night
$84 total
Feb 15 - Feb 16
Total with taxes and fees
At Wyndham Garden Jacksonville, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. If you drive, put free parking to good use. The front desk has multilingual staff on hand 24/7 to help with luggage storage, concierge services, and securing valuables. Additional amenities include a conference center, a 24-hour business center, and a computer station.
Southbank Hotel by Marriott Jacksonville Riverwalk

Southbank Hotel by Marriott Jacksonville Riverwalk

3.5 out of 5
1515 Prudential Dr Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
13.6 mi from Isle of Palms
$116 nightly
The price is $132 total per night
$132 total
Feb 22 - Feb 23
Total with taxes and fees
At Southbank Hotel by Marriott Jacksonville Riverwalk, guests enjoy features like an outdoor pool, a gym, and free WiFi in public areas. Valet parking is offered for USD 22.00 per day. The 24-hour front desk has multilingual staff ready to assist with dry cleaning/laundry, luggage storage, and concierge services. If you like to take your furry friend along on your adventures, this pet-friendly property offers food and water bowls. Additional amenities include a conference center, a 24-hour business center, and express check-in.
Pool
Pet friendly
Hyatt Regency Jacksonville

Hyatt Regency Jacksonville

4 out of 5
225 E Coastline Dr Jacksonville FL
13.86 mi from Isle of Palms
$214 nightly
The price is $243 total per night
$243 total
Feb 9 - Feb 10
Total with taxes and fees
At Hyatt Regency Jacksonville, guests enjoy an outdoor pool, a 24-hour gym, and free WiFi in public areas. Valet parking is available for USD 44 per day. The 24-hour front desk has multilingual staff ready to assist with luggage storage, concierge services, and securing valuables. Additional amenities include conference space, a business center, and express check-in.
The Villas of Amelia Island

The Villas of Amelia Island

4 out of 5
8 Amelia Village Circle, Amelia Island Fernandina Beach FL
Free Cancellation
Reserve now, pay when you stay
18.27 mi from Isle of Palms
$209 nightly
The price is $234 total per night
$234 total
Feb 27 - Feb 28
Total with taxes and fees
The Villas of Amelia Island features a golf course, a full-service spa, and 2 outdoor pools. Transportation is made easy with limo/town car service. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, securing valuables, and luggage storage. Other amenities at this beach vacation home include an indoor pool, a children's pool, and a 24-hour gym.
Extended Stay America Premier Suites - Jacksonville - Airport

Extended Stay America Premier Suites - Jacksonville - Airport

2.5 out of 5
15678 Max Leggett Parkway Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
19.11 mi from Isle of Palms
$85 nightly
The price is $97 total per night
$97 total
Feb 8 - Feb 9
Total with taxes and fees
Renovated in 2025, Extended Stay America Premier Suites - Jacksonville - Airport offers a 24-hour gym, free WiFi in public areas, and coffee in a common area. There's free parking if you drive. The 24-hour front desk has staff always at the ready. This hotel also has laundry facilities.
Hyatt Place Jacksonville Airport

Hyatt Place Jacksonville Airport

3 out of 5
14565 Duval Rd Jacksonville FL
Free Cancellation
Reserve now, pay when you stay
19.34 mi from Isle of Palms
$110 nightly
The price is $125 total per night
$125 total
Feb 9 - Feb 10
Total with taxes and fees
Built in 2028, the brand new Hyatt Place Jacksonville Airport offers an outdoor pool, a 24-hour gym, and free WiFi in public areas. There's free parking, as well as a free airport shuttle (available 24 hours). The 24-hour front desk has staff standing by to help with dry cleaning/laundry, luggage storage, and securing valuables. Additional amenities include meeting rooms, conference space, and a 24-hour business center.
Omni Amelia Island Resort & Spa

Omni Amelia Island Resort & Spa

4 out of 5
39 Beach Lagoon Road Fernandina Beach FL
Free Cancellation
Reserve now, pay when you stay
19.48 mi from Isle of Palms
$329 nightly
The price is $369 total per night
$369 total
Feb 8 - Feb 9
Total with taxes and fees
Omni Amelia Island Resort & Spa features a golf course, a full-service spa, and 2 outdoor pools. Valet parking is offered for USD 40 per day. Front-desk staff can answer questions 24/7, and assist with dry cleaning/laundry, tours or tickets, and luggage storage. Other amenities at this beach resort include an indoor pool, a children's pool, and a 24-hour gym.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Isle of Palms Hotels

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Great selection of hotels in Isle of Palms

Whether you're searching for hotels in Isle of Palms on business, or hunting for a family getaway, Isle of Palms hotel options are only a click away. Find hotels in Isle of Palms with the location, star-rating and facilities you need. Narrow your search results even further by star rating, hotel chain and amenities, such as free parking, babysitting services, or fitness centers. And with area maps, you can view Isle of Palms hotels close you are to the airport and nearby attractions.

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Isle of Palms hotels essential information

Accommodation
3,272 hotels
Lowest Price
$84
Highest Price
$369
Popular hotels
Residence Inn By Marriott Jacksonville - Mayo Clinic Area, Margaritaville Jacksonville Beach, Hyatt Regency Jacksonville, The Villas of Amelia Island, Southbank Hotel by Marriott Jacksonville Riverwalk, Hyatt Place Jacksonville Airport, Wyndham Garden Jacksonville, Omni Amelia Island Resort & Spa, Extended Stay America Premier Suites - Jacksonville - Airport

Popular places to visit

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St. Johns Town Center

With a visit to St. Johns Town Center, a favorite shopping spot in Jacksonville, you can enjoy some retail therapy. Stroll along the area's riverfront or experience its acclaimed theater scene.

See properties in St. Johns Town Center
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Mayo Clinic Florida

Though Mayo Clinic Florida might be what brings you to town, perhaps you'll have a chance to explore more of Jacksonville while you are here.

See properties in Mayo Clinic Florida
Mayo Clinic Florida
While attending the Florida Lighthouse Association's annual conference we visited two lighthouses on the Mayport Base. We beat the rain before heading back to the conference.

Mayport Naval Station

Mayport Naval Station is just one of the places to see in Jacksonville, so why not enjoy the other things to explore during your travels? Amble around this family-friendly area's beautiful beaches or experience its entertainment choices.

See properties in Mayport Naval Station
Mayport Naval Station

Recent Reviews

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

5/5 Excellent
"Staff "
A verified traveler stayed at Margaritaville Jacksonville Beach
Posted 3 days ago
Margaritaville Jacksonville Beach