Beginning of main content
Due to coronavirus (COVID-19) travel advisories, some destinations may be unavailable for certain dates. Find out more.

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Tonight
This weekend
Dec 4 - Dec 6
Next weekend
Dec 11 - Dec 13

Featured Hotels near Mayo Clinic

Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5.00.1 km from Mayo Clinic
Free Cancellation
$98
3.8/5 (83 reviews)

Close proximity to Mayo clinic and restaurants all within walking distance. We didn't like the heating/cooling system, which wasn't working properly. Very close quarters parking ramp and driving in the parking ramp narrow passage ways very little room meeting other vehicles. Otherwise was all good ...

Reviewed on Sep 18, 2020
Guests of Kahler Inn and Suites - Mayo Clinic Area enjoy a fitness center, free WiFi in public areas, and a meeting room. If you drive, self parking is USD 15.00 ...
Kahler Grand Hotel
Kahler Grand Hotel
3.0 out of 5.00.2 km from Mayo Clinic
Free Cancellation
$139
3.4/5 (77 reviews)

It was very close to where I needed to be, staff was excellent, but it's a bit, um, rustic.

Reviewed on Dec 13, 2019
At Kahler Grand Hotel, guests enjoy features like an indoor pool, a 24-hour fitness center, and a sauna. Valet parking is offered for USD 24.00 per day. The ...
Marriott Rochester Mayo Clinic
Marriott Rochester Mayo Clinic
3.5 out of 5.00.2 km from Mayo Clinic
Free Cancellation
$127
4.1/5 (20 reviews)

staff is friendly, food is good but the facility is worn....needs remodeled.

Reviewed on Mar 8, 2019
At Marriott Rochester Mayo Clinic, guests enjoy features like an indoor pool, a 24-hour fitness center, and a spa tub. Parking is available for USD 16.00 per ...
DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area
DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area
3.5 out of 5.00.4 km from Mayo Clinic
Free Cancellation
$127
4.1/5 (28 reviews)

Easy access to hospital. Great customer service. Close to restaurants

Reviewed on Jun 26, 2020
At DoubleTree by Hilton Hotel Rochester - Mayo Clinic Area, guests enjoy an indoor pool, a 24-hour fitness center, and a sauna. Parking is available for USD ...
Brentwood Inn & Suites
Brentwood Inn & Suites
2.5 out of 5.00.3 km from Mayo Clinic
Free Cancellation
$81
3.9/5 (10 reviews)

Great location and great staff. Clean comfortable and quiet room.

Reviewed on Feb 19, 2020
Guests of Brentwood Inn & Suites enjoy free WiFi in public areas, a 24-hour business center, and free newspapers. The front desk is staffed 24/7 to help with ...
Hilton Garden Inn Rochester Downtown, MN
Hilton Garden Inn Rochester Downtown, MN
3.0 out of 5.00.4 km from Mayo Clinic
Free Cancellation
$110
4.4/5 (28 reviews)

Great location. Perfect walking distance to mayo and several restaurants

Reviewed on Jul 25, 2020
At Hilton Garden Inn Rochester Downtown, MN, guests enjoy features like an indoor pool, a 24-hour fitness center, and a spa tub. Parking is available for USD ...
Hilton Rochester Mayo Clinic Area
Hilton Rochester Mayo Clinic Area
3.5 out of 5.00.4 km from Mayo Clinic
Free Cancellation
$199
5.0/5 (7 reviews)

Wonderful stay, highly recommend. Would return. Staff throughout the entire hotel were helpful and very friendly. Very much appreciated the hotel transportation to the hospital. The restaurant food was one of the best meals I have had in years. Thank you for making everything so comfortable. I have ...

Reviewed on Jun 8, 2019
Built in 2019, the brand new Hilton Rochester Mayo Clinic Area features a full-service spa, an indoor pool, and a 24-hour fitness center. Valet parking is available ...
Hotel Indigo Rochester Downtown
Hotel Indigo Rochester Downtown
3.0 out of 5.00.4 km from Mayo Clinic
Free Cancellation
$92
5.0/5 (1 reviews)
Hotel Indigo Rochester Downtown offers a 24-hour fitness center, a rooftop terrace, and free WiFi in public areas. Valet parking is offered for USD 22.00 per ...
Centerstone Plaza Hotel Soldiers Field/Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field/Mayo Clinic Area
3.0 out of 5.00.6 km from Mayo Clinic
Free Cancellation
$104
3.8/5 (27 reviews)

Great location near clinic and park near by. Very close to coop store.

Reviewed on Jul 2, 2020
Centerstone Plaza Hotel Soldiers Field/Mayo Clinic Area features an indoor pool, a children's pool, and a 24-hour fitness center. You can take advantage of free ...

Looking for a great deal on a hotel near Mayo Clinic?

Then Orbitz is the only place to book! Not only is Mayo Clinic a major attraction, but Rochester also has so much to offer travelers. On top of plenty of great places to stay, there are other attractions to visit in Rochester when you’re done at Mayo Clinic.

Book your vacation to Mayo Clinic with Orbitz for a trip you won’t soon forget.

Grab Mayo Clinic hotel deals and special offers

Orbitz works around the clock to find exclusive offers and Rochester hotel deals, just for you. Sign up for deals by email where you'll get first crack at money-saving extras like promo codes, resort credits, free nights and more. You can also "Like" Orbitz on Facebook and follow us on Twitter to receive up-to-the-minute news on hotel discounts, giveaways and more.

24/7 support with Mayo Clinic hotel reservations

When it comes to finding hotels near Mayo Clinic, an Orbitz specialist can help you find the right property for you. Chat live or call 1-800-454-3743 any time for help booking your hotels near Mayo Clinic. Our team of experts can help you pinpoint Rochester hotel options suited to your tastes and budget.

Forget Orbitz change or cancel fees on Mayo Clinic hotels

On Orbitz, Rochester hotel deals mean flexibility. If you need to change your Mayo Clinic hotel reservations, or cancel your stay, Orbitz doesn't charge cancel or change fees. Orbitz also offers great selection on airline tickets, vacation packages, and car rental deals to so you can plan your trip all in one place.

Are there hotels with free wifi near Mayo Clinic?

Definitely. After a long day out in Rochester at Mayo Clinic, it’s nice to come back and relax at your hotel knowing they have free wifi. Binge on your favorite online show, or check the weather forecast and plan your activities for the next day. Either way, hotels near Mayo Clinic with free wifi are the best option for your trip. Instead of scouring the web to find all the Rochester hotels with free wifi, browse our listings of the best hotels offering free wifi near Mayo Clinic.

Can I book hotels near Mayo Clinic with free breakfast?

You sure can! You know what they say, breakfast is the most important meal of the day. Before your day exploring Rochester, make sure to fill up with a good, hearty breakfast from your hotel. Check out some of our best deals below:

Are there pet-friendly hotels near Mayo Clinic?

Yes, there are. Don’t want to leave the pups behind on your trip to Rochester? You don’t have to! At Orbitz, we know no trip is complete without man’s best friend. That’s why we’ve found these awesome hotels near Mayo Clinic that allow pets.

Where can I find hotels near Mayo Clinic with restaurants?

Although it’s fun to taste the local cuisine on your trip to visit Mayo Clinic, sometimes it’s nice not to worry about what’s for dinner or where to go. Our hotels with restaurants in Rochester will allow you to just lay low after a day of exploring Mayo Clinic and enjoy a great meal without leaving the comfort of your hotel.

What are the best deals on Mayo Clinic hotels with pools?

If you want to cool off in the pool after a great day out in Rochester exploring Mayo Clinic, our deals are just what you need. We offer discount rates on the top hotels near Mayo Clinic that have pools.

Are there hotels near Mayo Clinic with parking?

If you’re planning to drive around Rochester, or if you want to leave your car somewhere safe to walk from your hotel to Mayo Clinic, you’ll want to check out our deals on hotels near Mayo Clinic with parking. We've found deals on bookings for hotels near Mayo Clinic that have parking on-site for guests.

Is there 24-hour concierge service at Mayo Clinic hotels?

Sometimes travel can be unpredictable. Maybe your flight gets delayed and you miss check-in time, or you decide to stay late at Mayo Clinic and return after the front desk is closed. Either way, you don’t want to get stuck without 24-hour concierge services at your hotel near Mayo Clinic.

Can I book a hotel near Mayo Clinic with non-smoking rooms?

Sometimes it’s nice to explore a new area on foot to really get a feel for the lay of the land. Explore Rochester like a local and stay within walking distance of Mayo Clinic without going over budget.

Where can I book 4-star hotels close to Mayo Clinic?

We’ve found 1 4-star hotels near Mayo Clinic that offer great deals on nightly rates. When you book a 4-star hotel near Mayo Clinic you book the ease of knowing that one of your favorite destinations is a short trip away. Check out our best deals on 4-star hotels near Mayo Clinic below:

What are the cheapest 3-star hotels near Mayo Clinic?

Looking to save a little cash on your trip to visit Mayo Clinic? We get it. You want to splurge on outings and activities, without blowing your budget on hotel rooms. Our 3-star hotels are perfect for a budget-friendly trip to explore Rochester and check out Mayo Clinic. Browse our best deals on 3-star hotels near Mayo Clinic below.

Recent Reviews

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.