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Dec 26 - Dec 27
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Featured Florence Boutique Hotels

Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
Free Cancellation
Reserve now, pay when you stay
$130 nightly
The price is $146 total per night
$146 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at Hotel Florence, Tapestry Collection by Hilton enjoy access to a full-service spa, a 24-hour gym, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with securing valuables and dry cleaning/laundry. Other amenities at this spa hotel include meeting rooms, conference space, and a 24-hour business center.
Spa
Parking included
The Inn at the Crossroads

The Inn at the Crossroads

2 out of 5
128 West Main Street Lake City SC
Free Cancellation
Reserve now, pay when you stay
$127 nightly
The price is $143 total per night
$143 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
The Inn at the Crossroads features a 24-hour gym, free WiFi in public areas, and a conference center. There's free parking if you drive. The front desk is staffed 24/7 to help with securing valuables, tours or tickets, and luggage storage. Additional amenities include a 24-hour business center, coffee/tea in a common area, and a terrace.
Breakfast included
Parking included
The Mantissa Hotel

The Mantissa Hotel

3 out of 5
130 East Carolina Ave Hartsville SC
Free Cancellation
Reserve now, pay when you stay
$162 nightly
The price is $181 total per night
$181 total
Jan 4 - Jan 5, 2026
Total with taxes and fees
Guests staying at The Mantissa Hotel enjoy a gym, a rooftop terrace, and free WiFi in public areas. If you decide to drive, there's free parking. The 24-hour front desk has staff standing by to help with securing valuables and luggage storage. Additional amenities include a business center and a banquet hall.
Breakfast included
Parking included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Florence hotels essential information

Accommodation
366 hotels
Lowest Price
$143
Highest Price
$181
Popular hotels
Hotel Florence, Tapestry Collection by Hilton, The Inn at the Crossroads, The Mantissa Hotel

Recent Boutique Hotels Reviews

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

5/5 Excellent
"Clean room. Quiet !!"
A verified traveler stayed at Howard Johnson by Wyndham Florence
Posted 3 days ago
Howard Johnson by Wyndham Florence

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