$220 Cheap flights to Santa Cruz

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Santa Cruz

Santa Cruz

Cheap flights to Santa Cruz from $220 One Way, $482 Round Trip

$482 return flights and $220 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Mar 16 - Tue, Mar 31
MIA
Miami
VVI
Santa Cruz
$482 Roundtrip, found 1 day ago
$482
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Mar 16 from Miami to Santa Cruz, returning Tue, Mar 31, priced at $482 found 1 day ago
Mon, Mar 16 - Tue, Mar 31
MIA
Miami
VVI
Santa Cruz
$492 Roundtrip, found 1 day ago
$492
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Mar 16 from Miami to Santa Cruz, returning Tue, Mar 31, priced at $492 found 1 day ago
Mon, Mar 16 - Tue, Mar 31
MIA
Miami
VVI
Santa Cruz
$501 Roundtrip, found 1 day ago
$501
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Mar 16 from Miami to Santa Cruz, returning Tue, Mar 31, priced at $501 found 1 day ago
Thu, Apr 16 - Mon, Apr 27
MIA
Miami
VVI
Santa Cruz
$520 Roundtrip, just found
$520
Roundtrip
just found
Select avianca flight, departing Thu, Apr 16 from Miami to Santa Cruz, returning Mon, Apr 27, priced at $520 just found
Thu, Apr 16 - Mon, Apr 27
FLL
Fort Lauderdale
VVI
Santa Cruz
$538 Roundtrip, just found
$538
Roundtrip
just found
Select avianca flight, departing Thu, Apr 16 from Fort Lauderdale to Santa Cruz, returning Mon, Apr 27, priced at $538 just found
Fri, May 8 - Sat, May 16
MIA
Miami
VVI
Santa Cruz
$566 Roundtrip, found 8 hours ago
$566
Roundtrip
found 8 hours ago
Select LATAM Airlines Group flight, departing Fri, May 8 from Miami to Santa Cruz, returning Sat, May 16, priced at $566 found 8 hours ago
Tue, Mar 10 - Fri, Mar 13
IAD
Washington
VVI
Santa Cruz
$588 Roundtrip, just found
$588
Roundtrip
just found
Select Copa flight, departing Tue, Mar 10 from Washington to Santa Cruz, returning Fri, Mar 13, priced at $588 just found

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
MIASanta CruzFebruary 1 to February 26$904
BWISanta CruzFebruary 1 to February 11$1,001
IADSanta CruzFebruary 1 to February 5$1,138
LAXSanta CruzJanuary 31 to February 13$1,186
JFKSanta CruzJanuary 31 to February 9$1,434
MADSanta CruzJanuary 31 to February 11$1,779
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$144 nightly
The price is $144 total per night from Feb 11 to Feb 12
$144 total
Feb 11 - Feb 12
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (354 reviews)
Indeed this is a First Class hotel. Beautiful lobby, great dining area, beautiful pool, ample rooms.

Reviewed on Jan 17, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Dr Victor Pinto, Equipetrol Santa Cruz
Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...
8/10 Very Good! (201 reviews)
So, the mattress and pillows were not that comfortable, hard. No microwave and the sheets not the size of the bed, smaller. The treatment from the hotel personnel was good.

Reviewed on Feb 21, 2025

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Opens in a new windowHotel LP Equipetrol
Yotau All Suites Hotel

Yotau All Suites Hotel

3.5 out of 5
Av. San Martin No. 7 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...
6.8/10 (76 reviews)
My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom

Reviewed on Aug 3, 2025

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Opens in a new windowYotau All Suites Hotel
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Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3 out of 5
Av.Ejercito Nacional 290 Santa Cruz
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...
7.8/10 Good! (281 reviews)
Clean rooms, well kept facilities and nice staff

Reviewed on Dec 10, 2025

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Opens in a new windowHotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz Apartment Hotels

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (97 reviews)
Yes, staff were very friendly

Reviewed on Dec 29, 2025

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Opens in a new windowApart Hotel Premium Suites Santa Cruz
Apartamento Irala

Apartamento Irala

3 out of 5
Calle Prolongancion Cochabamba, S/N Santa Cruz
Book a stay at this spa apartment in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Blacutt Square and Museo de Historia ...
Good location. Building is new. Security is good. Condo unit is spacious for 2 people. Quiet environment. Responsive and reliable owner. Air-conditioning in bedroom only which is still acceptable.

Reviewed on Apr 16, 2019

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Opens in a new windowApartamento Irala
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
7.4/10 Good! (93 reviews)
Extremely satisfy with the service that this resort provided to us. Definitely will return back. Follow me on YouTube #TeamWithERVING

Reviewed on Aug 14, 2021

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Casa por Temporadas

Casa por Temporadas

3.5 out of 5
Avenida Cristo Redentor Santa Cruz
Stay at this vacation home in Santa Cruz. Enjoy free WiFi, free parking, and an airport shuttle (surcharge). Popular attractions Play Land Amusement Park and ...
Great place to stay, great attention
The owners were happy to answer all our questions by email before our arrival. The pool was very nice but know that it has no shallow end. The pool table and air hockey table were nice additions, especially if it happens to rain while you are there. The owners know a great taxi driver if you don't ...

Reviewed on Sep 21, 2016

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Opens in a new windowCasa por Temporadas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Santa Cruz Accommodation Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
$43 nightly
The price is $43 total per night from Jan 30 to Jan 31
$43 total
Jan 30 - Jan 31
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (84 reviews)
Loved the fact we could check in early for a minimal fee. Staff were nice. The room was good but a bit stuffy and the air conditioning unit had a lot of dirt and dust in it. There was also a weird smell that they sprayed that was a bit nauseating. Otherwise the hotel had a great vibe and was decorated ...

Reviewed on Jan 13, 2026

Opens in a new windowIbis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$144 nightly
The price is $144 total per night from Feb 11 to Feb 12
$144 total
Feb 11 - Feb 12
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (354 reviews)
Indeed this is a First Class hotel. Beautiful lobby, great dining area, beautiful pool, ample rooms.

Reviewed on Jan 17, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
$92 nightly
The price is $92 total per night from Feb 6 to Feb 7
$92 total
Feb 6 - Feb 7
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (213 reviews)
Muy bien exelente

Reviewed on Dec 9, 2025

Opens in a new windowMarriott Santa Cruz de la Sierra Hotel
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Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
$97 nightly
The price is $97 total per night from Jan 30 to Jan 31
$97 total
Jan 30 - Jan 31
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (337 reviews)
I appreciate the reliability of the Sun Hotel’s shuttle service whisking you from the airport to a comfortable room after a long day’s travel. The breakfast the next morning, some time in the fitness room and a swim in the pool was everything I needed to be ready to continue my trip.

Reviewed on Jan 24, 2026

Opens in a new windowSun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$144 nightly
The price is $144 total per night from Feb 11 to Feb 12
$144 total
Feb 11 - Feb 12
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (354 reviews)
Indeed this is a First Class hotel. Beautiful lobby, great dining area, beautiful pool, ample rooms.

Reviewed on Jan 17, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (97 reviews)
Yes, staff were very friendly

Reviewed on Dec 29, 2025

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Opens in a new windowApart Hotel Premium Suites Santa Cruz
Buganvillas Hotel Suites & Spa
Great for families

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
7.4/10 Good! (93 reviews)

Families like: Kids pool, cribs, rollaway beds, outdoor tennis courts

Travelers say...
Extremely satisfy with the service that this resort provided to us. Definitely will return back. Follow me on YouTube #TeamWithERVING

Reviewed on Aug 14, 2021

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Opens in a new windowBuganvillas Hotel Suites & Spa
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Camino Real Hotel
Great for families

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
$120 nightly
The price is $120 total per night from Mar 1 to Mar 2
$120 total
Mar 1 - Mar 2
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz ...
8.8/10 Excellent! (413 reviews)

Families like: Kids pool, waterslide, playground, babysitting

Travelers say...
Rooms were very clean and service was excellent

Reviewed on Jan 21, 2026

Opens in a new windowCamino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark or similar
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus or similar
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla or similar
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass or similar
  • 5 people
Jeep Compass
SUV Jeep Compass

Santa Cruz

Why search for low cost fares on your flights to Santa Cruz when Orbitz offers the guaranteed lowest prices on foreign and domestic flights? When you travel with Orbitz you can benefit from:

Bargain Flights to Santa Cruz

Orbitz offers massive discounts and substantial last-minute savings on your Santa Cruz flights. Orbitz ensures that you can find, plan and reserve your flights any destination with ease, all while enjoying the guaranteed lowest prices available anywhere.

Cutting-Edge Mobile Tools to Keep You In The Know

Orbitz sends you free alerts and updates on your Santa Cruz flight wherever you are in the world. Once you have downloaded the free app for your iPhone, Android, or iPad, you can review or alter any travel plans that you have made or even book a future flight for business or pleasure. If you need to reserve a hotel room when booking your flight, you will find exclusive deals on our mobile site.

Frequent Flyer Program Enrolment

Orbitz finds you the lowest fares, but you can still add your miles to your frequent flyer program to earn miles or points on selected flights to Santa Cruz. When making your booking, reference your frequent flyer number to receive discounts in the future.

Outstanding Customer Service

Orbitz values your business and wants to ensure that all of your flights are as easy as possible to book. If you have booked a flight to Santa Cruz but need to cancel it, you may be able to do so online. If you have any questions or need help, the dedicated Orbitz customer service team is always standing by.

Frequently asked questions

Which airlines fly to Santa Cruz?
Book a ticket with one of the 14 airlines that operate services to Viru Viru Intl. Airport (VVI) and gear up for awesome new adventures. This popular airport is a main gateway for exploring Santa Cruz. When it's time to check off this region, these trusted carriers will take you there:

  • BoA - 89 flights to Santa Cruz per month
  • Copa Airlines - 22 flights to Santa Cruz per month
  • Aerolineas Argentinas - 17 flights to Santa Cruz per month

How much is a flight to Santa Cruz?
Travelers from far and wide landed round-trip bargains ranging between $482 and $1,779 this week to Santa Cruz. Starting your trip from Miami (MIA)? The most affordable one-way prices were $220.
How to book the cheapest flight to Santa Cruz?
Scoring cheap flights to Santa Cruz is as simple as booking your ticket with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips worth following:

  • Taking off from or landing at nearby airports can often help you save on airfares. Enter your preferred departure and arrival airports. Next, select the 'Nearby airports' function below to see what your options are.
  • Also, click on the 'Show flexible dates' option and you'll see the prices for days around your chosen departure. You may be able to pick up cheaper flight deals if your travel plans are flexible.
  • To filter your results, hit 'Show options.' You can search based on airlines, seating class, nonstop flights and refundable flights. You can also select your preferred flight times under 'Sort & Filter' to the left.
  • Reserve your fare as soon as you've decided on your travel dates. While you can get lucky on occasion, airline tickets rarely get more affordable as your date of departure gets closer.
  • Consider combining your flights, hotels and car rental into an Orbitz package to get more for your money.
  • If you can, avoid flying in high seasons. Airfares often surge during school breaks, summer and other vacation periods like Easter and Thanksgiving.

What is the best time to book a flight to Santa Cruz?
Generally speaking, January is the best time to book your plane ticket. This is closely followed by February and August. Keep this in mind while you browse for a cheap flight to Santa Cruz.
What day of the week is the cheapest to book a flight to Santa Cruz?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days of the week to book a flight to Santa Cruz. If you want the most competitive airfares, search across those days and you just might land an excellent flight deal.
What is the cheapest day of the week to fly to Santa Cruz?
According to Orbitz data from 2020, you should kick off your trip on a Monday to nab cheap flights to Santa Cruz. Next most inexpensive day? Tuesday. Saturday costs the most. So, depart early in the week if you'd like to score a wallet-friendly fare without paying premium prices.
What is the cheapest month to fly to Santa Cruz?
We won't keep you in suspense — based on Orbitz data, August is generally the cheapest month to fly. Perfect for those who want a weekend getaway or simply escape from it all before the weather changes. The costliest time to fly is the height of summer, with fares at their highest in June.
Which airlines allow free cancellation?
Orbitz makes it a snap to find carriers that offer flexibility. Simply click on "Filter by flexible change policies" when searching for your Santa Cruz flights and boom! We'll show you options that include free cancellation within 24 hours of booking, no change fees and of course, an irresistible low price.
What do I need for the flight to Santa Cruz?
A lengthy flight can be daunting, but it's nothing a little preparation can't solve. We've compiled our top suggestions to ensure your journey is as smooth as possible:

  • In all cases you'll need some identification. How much? This depends on where you're traveling from. When reserving your flight tickets, we suggest to put down the same name, gender and birth date as displayed on your government-issued ID.
  • Take a good book or a laptop crammed with your favorite TV series — it'll help to keep you busy on your journey to Santa Cruz. Or if you'd rather enjoy a nap, a comfy eye mask will block out those bright cabin lights.
  • Long-haul trips can leave you feeling seriously cold, especially if you're flying overnight. If you don't want to curl up to the stranger beside you for warmth, bring your favorite hoodie and some wool socks.

How do I get cheap first-class/business deals to Santa Cruz?
If you think a first or business-class fare is out of your price range, you may want to think again. Here are some practical tips to help you score a premium flight to Santa Cruz for a whole lot less:

  • Be flexible with your travel dates and hold out for deals on business or first-class airfares.
  • Many budget airlines these days have superb business-class seating that doesn't cost an arm and a leg.
  • Take advantage of your airline's loyalty scheme and upgrade your seat. Alternatively, you can try bidding for an upgrade in online auctions.

What is the best time to go to Santa Cruz?
March, August and September are the most popular months to vacation in Santa Cruz. If an average daily high of 90 ºF sounds attractive, book your trip for the start of summer — December 1. Many tourists prefer this time of year for its warmer weather. In the evening, the average temperature falls to 70 ºF.
Travel tips for Santa Cruz

  • Santa Cruz is full of interesting attractions and Plaza 24 de Septiembre is one of them. Lock in a car rental and head there at your convenience.
  • Colinas del Urubo offers plenty of exciting experiences and is a great place to kick off your escape. Whether your scene is cafés, restaurants, art or something else, this city will keep you busy.

More to Explore

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.