$263 Cheap flights to Santa Cruz

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Top places to visit in Santa Cruz

A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz

Cheap flights to Santa Cruz from $263 One Way, $566 Round Trip

$566 return flights and $263 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 30 - Sun, Nov 8

MIA

Miami

VVI

Santa Cruz

$566

Roundtrip

found 1 hour ago

Thu, Sep 17 - Mon, Sep 28

MIA

Miami

VVI

Santa Cruz

$572

Roundtrip

found 7 hours ago

Thu, Aug 27 - Mon, Aug 31

MIA

Miami

VVI

Santa Cruz

$577

Roundtrip

found 3 hours ago

Sat, Aug 15 - Mon, Aug 31

MIA

Miami

VVI

Santa Cruz

$578

Roundtrip

just found

Wed, Sep 9 - Wed, Sep 16

FLL

Fort Lauderdale

VVI

Santa Cruz

$580

Roundtrip

found 3 days ago

Fri, Mar 19 - Sun, Mar 28

MIA

Miami

VVI

Santa Cruz

$598

Roundtrip

found 5 hours ago

Deals For This Weekend's Flights

Origin	Destination	Travel Dates	Flights From*
IAD	Santa Cruz	July 26 to August 12	$1,002
IAD	Santa Cruz	July 26 to August 12	$1,002
IAD	Santa Cruz	July 26 to August 12	$1,002
IAD	Santa Cruz	July 26 to August 12	$1,002
MIA	Santa Cruz	July 24 to August 11	$1,053
MIA	Santa Cruz	July 24 to August 11	$1,053
LAX	Santa Cruz	July 24 to July 31	$1,160
LAX	Santa Cruz	July 24 to July 31	$1,160
JFK	Santa Cruz	July 26 to August 3	$1,561
JFK	Santa Cruz	July 26 to August 3	$1,561
MAD	Santa Cruz	July 26 to August 31	$2,361
MAD	Santa Cruz	July 26 to August 31	$2,361

*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$118 nightly

$118 total

Aug 23 - Aug 24

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (392 reviews)

"Wildlife on property. Great breakfast. Amazing spa. Great rooms. Professional atmosphere. My favorite hotel in Santa Cruz."

Reviewed on Jul 21, 2026

Hotel LP Equipetrol

Dr Victor Pinto, Equipetrol Santa Cruz

$44 nightly

$44 total

Jul 25 - Jul 26

Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...

8.2/10 Very Good! (210 reviews)

"El cuarto agradable, pero faltó servicio de ayuda para subir y bajar maletas, también servicio adecuado de taxi para moverse en Santa Cruz"

Reviewed on Jul 14, 2026

Yotau All Suites Hotel

Av. San Martin No. 7 Santa Cruz

$113 nightly

$113 total

Jul 24 - Jul 25

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...

7/10 Good! (76 reviews)

"My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom"

Reviewed on Aug 3, 2025

Save an average of 15% on thousands of hotels when you're signed in

Hotel LP Santa Cruz Centro

Av.Ejercito Nacional 290 Santa Cruz

$50 nightly

$50 total

Aug 14 - Aug 15

Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...

8/10 Very Good! (285 reviews)

"Awesome hotel"

Reviewed on Feb 6, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz Apartment Hotels

Apart Hotel Premium Suites Santa Cruz

Calle Las Begonias Nro 45 Santa Cruz

$27 nightly

$27 total

Jul 24 - Jul 25

Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...

8.8/10 Excellent! (103 reviews)

"Great location."

Reviewed on Jun 4, 2026

Apartamento Irala

Calle Prolongancion Cochabamba, S/N Santa Cruz

Book a stay at this spa apartment in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Blacutt Square and Museo de Historia ...

8/10 Very Good! (1 review)

"Good location. Building is new. Security is good. Condo unit is spacious for 2 people. Quiet environment. Responsive and reliable owner. Air-conditioning in bedroom only which is still acceptable."

Reviewed on Apr 16, 2019

Get rates

Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901 Santa Cruz

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Get rates

Save an average of 15% on thousands of hotels when you're signed in

Casa por Temporadas

Avenida Cristo Redentor Santa Cruz

Stay at this vacation home in Santa Cruz. Enjoy free WiFi, free parking, and an airport shuttle (surcharge). Popular attractions Play Land Amusement Park and ...

10/10 Exceptional! (1 review)

Great place to stay, great attention

"The owners were happy to answer all our questions by email before our arrival. The pool was very nice but know that it has no shallow end. The pool table and air hockey table were nice additions, especially if it happens to rain while you are there. The owners know a great taxi driver if you don't ..."

Reviewed on Sep 21, 2016

Get rates

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$118 nightly

$118 total

Aug 23 - Aug 24

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (392 reviews)

"Wildlife on property. Great breakfast. Amazing spa. Great rooms. Professional atmosphere. My favorite hotel in Santa Cruz."

Reviewed on Jul 21, 2026

Ibis Santa Cruz DE LA Sierra

AVENIDA CRISTOBAL DE MENDOZA Santa Cruz

$53 nightly

$53 total

Aug 6 - Aug 7

Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...

9.4/10 Exceptional! (127 reviews)

"Hotel muy lindo bien ubicado limpio el desayuno bueno y el personal A1 …. Totalmente recomendado"

Reviewed on Jul 22, 2026

Camino Real Hotel

Av. San Martín y 4to. Anillo Santa Cruz

$145 nightly

$145 total

Aug 4 - Aug 5

Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...

9/10 Wonderful! (433 reviews)

"Wonderful place to stay while visiting Santa Cruz Bolivia."

Reviewed on Jul 7, 2026

Save an average of 15% on thousands of hotels when you're signed in

TRYP by Wyndham Santa Cruz

Av. San Martin, Calle 9 Este Santa Cruz

$80 nightly

$80 total

Jul 24 - Jul 25

Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9.2/10 Wonderful! (166 reviews)

"Good Hotel, nice to walk and Good Restaurants. In my room they have a problem with the design of the bathroom that they have to take care."

Reviewed on Jun 26, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$118 nightly

$118 total

Aug 23 - Aug 24

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (392 reviews)

"Wildlife on property. Great breakfast. Amazing spa. Great rooms. Professional atmosphere. My favorite hotel in Santa Cruz."

Reviewed on Jul 21, 2026

Apart Hotel Premium Suites Santa Cruz

Calle Las Begonias Nro 45 Santa Cruz

$27 nightly

$27 total

Jul 24 - Jul 25

Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...

8.8/10 Excellent! (103 reviews)

"Great location."

Reviewed on Jun 4, 2026

Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901 Santa Cruz

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Families like: Kids pool, cribs, rollaway beds, outdoor tennis courts

Get rates

Save an average of 15% on thousands of hotels when you're signed in

Camino Real Hotel

Av. San Martín y 4to. Anillo Santa Cruz

$145 nightly

$145 total

Aug 4 - Aug 5

Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...

9/10 Wonderful! (433 reviews)

Families like: Kids pool, waterslide, playground, babysitting

Travelers say...

"Wonderful place to stay while visiting Santa Cruz Bolivia."

Reviewed on Jul 7, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark

4 people

Compact

Ford Focus

4 people

Midsize

Toyota Corolla

5 people

SUV

Jeep Compass

5 people

Santa Cruz

Finding cheap flights to Santa Cruz is easy when you have Orbitz at your fingertips. Not only does Orbitz offer great deals on Santa Cruz flights, but we also include some special extras to make booking a breeze. Just check out our:

Mobile Site and Apps

With Orbitz’s mobile site, m.orbitz.com, you can book your flights to Santa Cruz through your smartphone or tablet’s Web browser. Plus, our free downloadable apps for Android and iPhone mean it’s just a simple click to access your flight updates and alerts. You can even book exclusive mobile-only deals on hotels to go with your flights to Santa Cruz—even on the same day.

Pick and Choose or Book Full Vacation Packages

Don’t just be satisfied with great deals on Santa Cruz flights—go for the full package! With Orbitz, you can also find fantastic savings on the perfect hotel, car rental, cruise, and even activities, so you don’t waste your trip waiting in line but have the time to enjoy your trip. Pick and choose the add-ons you need, or book an entire vacation package for greater overall discounts.

Rewards That Are Miles Better

Booking directly with an airline earns you air miles or points, and you can get those same rewards with booking on Orbitz too. When you book qualifying flights to Santa Cruz with Orbitz, just add in your frequent flyer number during your online booking and your details will be sent to your program.

Great Deals Every Day

Add in our extra savings on packages, free nights, and other discounts, and you know you are in good hands.

Frequently asked questions

Which airlines fly to Santa Cruz?

Book a ticket with one of the 12 airlines that operate services to Viru Viru Intl. Airport (VVI) and gear up for awesome new adventures. This popular airport is a main gateway for exploring Santa Cruz. When it's time to check off this region, these trusted carriers will take you there:

BoA - 89 flights to Santa Cruz per month
Copa Airlines - 22 flights to Santa Cruz per month
Aerolineas Argentinas - 17 flights to Santa Cruz per month

How much is a flight to Santa Cruz?

Travelers from far and wide landed round-trip bargains ranging between $566 and $2,361 this week to Santa Cruz. Starting your trip from Fort Lauderdale (FLL)? The most affordable one-way prices were $263.

How to book the cheapest flight to Santa Cruz?

Scoring cheap flights to Santa Cruz is as simple as booking your ticket with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips worth following:

Taking off from or landing at nearby airports can often help you save on airfares. Enter your preferred departure and arrival airports. Next, select the 'Nearby airports' function below to see what your options are.
Also, click on the 'Show flexible dates' option and you'll see the prices for days around your chosen departure. You may be able to pick up cheaper flight deals if your travel plans are flexible.
To filter your results, hit 'Show options.' You can search based on airlines, seating class, nonstop flights and refundable flights. You can also select your preferred flight times under 'Sort & Filter' to the left.
Reserve your fare as soon as you've decided on your travel dates. While you can get lucky on occasion, airline tickets rarely get more affordable as your date of departure gets closer.
Consider combining your flights, hotels and car rental into an Orbitz package to get more for your money.
If you can, avoid flying in high seasons. Airfares often surge during school breaks, summer and other vacation periods like Easter and Thanksgiving.

What is the best time to book a flight to Santa Cruz?

Generally speaking, January is the best time to book your plane ticket. This is closely followed by February and August. Keep this in mind while you browse for a cheap flight to Santa Cruz.

What day of the week is the cheapest to book a flight to Santa Cruz?

Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days of the week to book a flight to Santa Cruz. If you want the most competitive airfares, search across those days and you just might land an excellent flight deal.

What is the cheapest day of the week to fly to Santa Cruz?

According to Orbitz data from 2020, you should kick off your trip on a Monday to nab cheap flights to Santa Cruz. Next most inexpensive day? Tuesday. Saturday costs the most. So, depart early in the week if you'd like to score a wallet-friendly fare without paying premium prices.

What is the cheapest month to fly to Santa Cruz?

We won't keep you in suspense — based on Orbitz data, August is generally the cheapest month to fly. Perfect for those who want a weekend getaway or simply escape from it all before the weather changes. The costliest time to fly is the height of summer, with fares at their highest in June.

Which airlines allow free cancellation?

Orbitz makes it a snap to find carriers that offer flexibility. Simply click on "Filter by flexible change policies" when searching for your Santa Cruz flights and boom! We'll show you options that include free cancellation within 24 hours of booking, no change fees and of course, an irresistible low price.

What do I need for the flight to Santa Cruz?

A lengthy flight can be daunting, but it's nothing a little preparation can't solve. We've compiled our top suggestions to ensure your journey is as smooth as possible:

In all cases you'll need some identification. How much? This depends on where you're traveling from. When reserving your flight tickets, we suggest to put down the same name, gender and birth date as displayed on your government-issued ID.
Take a good book or a laptop crammed with your favorite TV series — it'll help to keep you busy on your journey to Santa Cruz. Or if you'd rather enjoy a nap, a comfy eye mask will block out those bright cabin lights.
Long-haul trips can leave you feeling seriously cold, especially if you're flying overnight. If you don't want to curl up to the stranger beside you for warmth, bring your favorite hoodie and some wool socks.

How do I get cheap first-class/business deals to Santa Cruz?

If you think a first or business-class fare is out of your price range, you may want to think again. Here are some practical tips to help you score a premium flight to Santa Cruz for a whole lot less:

Be flexible with your travel dates and hold out for deals on business or first-class airfares.
Many budget airlines these days have superb business-class seating that doesn't cost an arm and a leg.
Take advantage of your airline's loyalty scheme and upgrade your seat. Alternatively, you can try bidding for an upgrade in online auctions.

What is the best time to go to Santa Cruz?

March, August and September are the most popular months to vacation in Santa Cruz. If an average daily high of 90 ºF sounds attractive, book your trip for the start of summer — December 1. Many tourists prefer this time of year for its warmer weather. In the evening, the average temperature falls to 70 ºF.

Travel tips for Santa Cruz

Santa Cruz is full of interesting attractions and Plaza 24 de Septiembre is one of them. Lock in a car rental and head there at your convenience.
Colinas del Urubo offers plenty of exciting experiences and is a great place to kick off your escape. Whether your scene is cafés, restaurants, art or something else, this city will keep you busy.

More to Explore

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.