$261 Cheap flights to Santa Cruz

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Top places to visit in Santa Cruz

Santa Cruz

Cheap flights to Santa Cruz from $261 One Way, $566 Round Trip

$566 return flights and $261 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Sep 11 - Fri, Sep 18

MIA

Miami

VVI

Santa Cruz

$566

Roundtrip

found 3 days ago

Sat, Aug 15 - Sat, Aug 22

MIA

Miami

VVI

Santa Cruz

$572

Roundtrip

found 2 days ago

Thu, Aug 27 - Mon, Aug 31

MIA

Miami

VVI

Santa Cruz

$578

Roundtrip

found 14 hours ago

Thu, Aug 27 - Mon, Aug 31

MIA

Miami

VVI

Santa Cruz

$587

Roundtrip

found 14 hours ago

Fri, Oct 9 - Sat, Oct 17

MIA

Miami

VVI

Santa Cruz

$598

Roundtrip

just found

Mon, Jun 8 - Fri, Jul 31

FLL

Fort Lauderdale

VVI

Santa Cruz

$605

Roundtrip

found 4 days ago

Deals For This Weekend's Flights

Origin	Destination	Travel Dates	Flights From*
PTY	Santa Cruz	May 15 to May 17	$584
PTY	Santa Cruz	May 15 to May 17	$584
CCS	Santa Cruz	May 16 to August 10	$603
MIA	Santa Cruz	May 15 to May 23	$634
MIA	Santa Cruz	May 15 to May 23	$634
IAD	Santa Cruz	May 15 to May 19	$734
IAD	Santa Cruz	May 15 to May 19	$734
IAD	Santa Cruz	May 15 to May 19	$734
IAD	Santa Cruz	May 15 to May 19	$734
LAX	Santa Cruz	May 17 to June 7	$770
LAX	Santa Cruz	May 17 to June 7	$770
JFK	Santa Cruz	May 16 to August 31	$871
JFK	Santa Cruz	May 16 to August 31	$871
MAD	Santa Cruz	May 15 to May 18	$1,460
MAD	Santa Cruz	May 15 to May 18	$1,460

*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$131 nightly

$131 total

May 29 - May 30

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (376 reviews)

Nice hotel

Reviewed on May 8, 2026

Hotel LP Equipetrol

Dr Victor Pinto, Equipetrol Santa Cruz

$42 nightly

$42 total

May 17 - May 18

Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...

Yotau All Suites Hotel

Av. San Martin No. 7 Santa Cruz

$113 nightly

$113 total

May 12 - May 13

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...

7/10 Good! (76 reviews)

My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom

Reviewed on Aug 3, 2025

Save an average of 15% on thousands of hotels when you're signed in

Hotel LP Santa Cruz Centro

Av.Ejercito Nacional 290 Santa Cruz

$47 nightly

$47 total

May 14 - May 15

Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...

8/10 Very Good! (285 reviews)

Awesome hotel

Reviewed on Feb 6, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz Apartment Hotels

Apart Hotel Premium Suites Santa Cruz

Calle Las Begonias Nro 45 Santa Cruz

$27 nightly

$27 total

May 12 - May 13

Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...

8.6/10 Excellent! (101 reviews)

Place is clean , safe area , walking distance to shops

Reviewed on Mar 10, 2026

Apartamento Irala

Calle Prolongancion Cochabamba, S/N Santa Cruz

Book a stay at this spa apartment in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Blacutt Square and Museo de Historia ...

8/10 Very Good! (1 review)

Good location. Building is new. Security is good. Condo unit is spacious for 2 people. Quiet environment. Responsive and reliable owner. Air-conditioning in bedroom only which is still acceptable.

Reviewed on Apr 16, 2019

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Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901 Santa Cruz

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Get rates

Save an average of 15% on thousands of hotels when you're signed in

Casa por Temporadas

Avenida Cristo Redentor Santa Cruz

Stay at this vacation home in Santa Cruz. Enjoy free WiFi, free parking, and an airport shuttle (surcharge). Popular attractions Play Land Amusement Park and ...

10/10 Exceptional! (1 review)

Great place to stay, great attention

The owners were happy to answer all our questions by email before our arrival. The pool was very nice but know that it has no shallow end. The pool table and air hockey table were nice additions, especially if it happens to rain while you are there. The owners know a great taxi driver if you don't ...

Reviewed on Sep 21, 2016

Get rates

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Santa Cruz Accommodation Deals

Ibis Santa Cruz DE LA Sierra

AVENIDA CRISTOBAL DE MENDOZA Santa Cruz

$59 nightly

$59 total

May 15 - May 16

Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...

9.6/10 Exceptional! (111 reviews)

Although the room was clean, it was very musty and wet smelling. Even with the air conditioner running, it did not seem to help. I found it difficult to communicate with the property, even in Spanish, because it took a long time for messages to be answered and the phone numbers for the property did ...

Reviewed on May 6, 2026

Sun Hotel

Av. Banzer Km 13 Santa Cruz Santa Cruz

$108 nightly

$108 total

May 12 - May 13

Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...

8.2/10 Very Good! (372 reviews)

The airport shuttle did not meet us after our flight, even though I had contacted the hotel in advance and they confirmed pick up. Very disappointing. The shuttle did take us back to the airport which was convenient. The hotel is terrible at responding to guests in advance if a stay. They eventually ...

Reviewed on May 1, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$131 nightly

$131 total

May 29 - May 30

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (376 reviews)

Nice hotel

Reviewed on May 8, 2026

Save an average of 15% on thousands of hotels when you're signed in

Marriott Santa Cruz de la Sierra Hotel

4to Anillo Entre Radial 23 Santa Cruz Santa Cruz

$122 nightly

$122 total

May 22 - May 23

Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...

9/10 Wonderful! (230 reviews)

Amazing time

Reviewed on Apr 9, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$131 nightly

$131 total

May 29 - May 30

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (376 reviews)

Nice hotel

Reviewed on May 8, 2026

Apart Hotel Premium Suites Santa Cruz

Calle Las Begonias Nro 45 Santa Cruz

$27 nightly

$27 total

May 12 - May 13

Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...

8.6/10 Excellent! (101 reviews)

Place is clean , safe area , walking distance to shops

Reviewed on Mar 10, 2026

Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901 Santa Cruz

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Families like: Kids pool, cribs, rollaway beds, outdoor tennis courts

Get rates

Save an average of 15% on thousands of hotels when you're signed in

Camino Real Hotel

Av. San Martín y 4to. Anillo Santa Cruz

$135 nightly

$135 total

May 30 - May 31

Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...

9/10 Wonderful! (426 reviews)

Families like: Kids pool, waterslide, playground, babysitting

Travelers say...

Excellent hotel, very clean, cozy, spotless and very stilish

Reviewed on Apr 19, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark

4 people

Compact

Ford Focus

4 people

Midsize

Toyota Corolla

5 people

SUV

Jeep Compass

5 people

Santa Cruz

Are you in the mood for a cruise? Shop Orbitz today for cheap cruises and flights to Santa Cruz. Our award-winning cruise site features exclusive offers, information for first-timers and top destinations and activities. Make discount domestic and international travel plans in an instant with cutting-edge mobile tools from Orbitz.

Top Pick

Orbitz holds a “Best of the Web” Cruise Site Award from Forbes Magazine. You won’t find better deals anywhere on low cost cruises and low fare Santa Cruz flights. Our Customer Care and guaranteed low prices make Orbitz the team to beat in budget cruises and air ticket sales.

Exclusive Offers

Register for Orbitz email updates and our cruise experts will notify you of bargain tickets on cruises as they’re posted. Install our free mobile apps on your iPad, iPhone or Android for easy booking and mobile-only savings on flights to Santa Cruz. Visit www.Orbitz.com to learn more about these amazing benefits and our 110% Best Price Guarantee.

First-Timers

Are you and your family cruise newbies? Orbitz offers Cruising 101 and Cruise FAQ to answer any questions you may have. Book your cruise and air travel with Orbitz On the Go for greater savings on Santa Cruz flights.

Ports and Play

Be sure to check our cruise page for free shore excursions, onboard spending, balcony upgrades and other perks. Orbitz offers last-minute, luxury, weekend and summer cruises. You can even designate which port you want to sail from and pre-book on-shore activities. Get there on the cheap with discounts on flights to Santa Cruz and Santa Cruz flights. Get more bang for your travel buck at Orbitz.

Frequently asked questions

Which airlines fly to Santa Cruz?

Book a ticket with one of the 12 airlines that operate services to Viru Viru Intl. Airport (VVI) and gear up for awesome new adventures. This popular airport is a main gateway for exploring Santa Cruz. When it's time to check off this region, these trusted carriers will take you there:

BoA - 89 flights to Santa Cruz per month
Copa Airlines - 22 flights to Santa Cruz per month
Aerolineas Argentinas - 17 flights to Santa Cruz per month

How much is a flight to Santa Cruz?

Travelers from far and wide landed round-trip bargains ranging between $566 and $1,460 this week to Santa Cruz. Starting your trip from Fort Lauderdale (FLL)? The most affordable one-way prices were $261.

How to book the cheapest flight to Santa Cruz?

Scoring cheap flights to Santa Cruz is as simple as booking your ticket with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips worth following:

Taking off from or landing at nearby airports can often help you save on airfares. Enter your preferred departure and arrival airports. Next, select the 'Nearby airports' function below to see what your options are.
Also, click on the 'Show flexible dates' option and you'll see the prices for days around your chosen departure. You may be able to pick up cheaper flight deals if your travel plans are flexible.
To filter your results, hit 'Show options.' You can search based on airlines, seating class, nonstop flights and refundable flights. You can also select your preferred flight times under 'Sort & Filter' to the left.
Reserve your fare as soon as you've decided on your travel dates. While you can get lucky on occasion, airline tickets rarely get more affordable as your date of departure gets closer.
Consider combining your flights, hotels and car rental into an Orbitz package to get more for your money.
If you can, avoid flying in high seasons. Airfares often surge during school breaks, summer and other vacation periods like Easter and Thanksgiving.

What is the best time to book a flight to Santa Cruz?

Generally speaking, January is the best time to book your plane ticket. This is closely followed by February and August. Keep this in mind while you browse for a cheap flight to Santa Cruz.

What day of the week is the cheapest to book a flight to Santa Cruz?

Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days of the week to book a flight to Santa Cruz. If you want the most competitive airfares, search across those days and you just might land an excellent flight deal.

What is the cheapest day of the week to fly to Santa Cruz?

According to Orbitz data from 2020, you should kick off your trip on a Monday to nab cheap flights to Santa Cruz. Next most inexpensive day? Tuesday. Saturday costs the most. So, depart early in the week if you'd like to score a wallet-friendly fare without paying premium prices.

What is the cheapest month to fly to Santa Cruz?

We won't keep you in suspense — based on Orbitz data, August is generally the cheapest month to fly. Perfect for those who want a weekend getaway or simply escape from it all before the weather changes. The costliest time to fly is the height of summer, with fares at their highest in June.

Which airlines allow free cancellation?

Orbitz makes it a snap to find carriers that offer flexibility. Simply click on "Filter by flexible change policies" when searching for your Santa Cruz flights and boom! We'll show you options that include free cancellation within 24 hours of booking, no change fees and of course, an irresistible low price.

What do I need for the flight to Santa Cruz?

A lengthy flight can be daunting, but it's nothing a little preparation can't solve. We've compiled our top suggestions to ensure your journey is as smooth as possible:

In all cases you'll need some identification. How much? This depends on where you're traveling from. When reserving your flight tickets, we suggest to put down the same name, gender and birth date as displayed on your government-issued ID.
Take a good book or a laptop crammed with your favorite TV series — it'll help to keep you busy on your journey to Santa Cruz. Or if you'd rather enjoy a nap, a comfy eye mask will block out those bright cabin lights.
Long-haul trips can leave you feeling seriously cold, especially if you're flying overnight. If you don't want to curl up to the stranger beside you for warmth, bring your favorite hoodie and some wool socks.

How do I get cheap first-class/business deals to Santa Cruz?

If you think a first or business-class fare is out of your price range, you may want to think again. Here are some practical tips to help you score a premium flight to Santa Cruz for a whole lot less:

Be flexible with your travel dates and hold out for deals on business or first-class airfares.
Many budget airlines these days have superb business-class seating that doesn't cost an arm and a leg.
Take advantage of your airline's loyalty scheme and upgrade your seat. Alternatively, you can try bidding for an upgrade in online auctions.

What is the best time to go to Santa Cruz?

March, August and September are the most popular months to vacation in Santa Cruz. If an average daily high of 90 ºF sounds attractive, book your trip for the start of summer — December 1. Many tourists prefer this time of year for its warmer weather. In the evening, the average temperature falls to 70 ºF.

Travel tips for Santa Cruz

Santa Cruz is full of interesting attractions and Plaza 24 de Septiembre is one of them. Lock in a car rental and head there at your convenience.
Colinas del Urubo offers plenty of exciting experiences and is a great place to kick off your escape. Whether your scene is cafés, restaurants, art or something else, this city will keep you busy.

More to Explore

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.