$222 Cheap flights to Santa Cruz

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Top places to visit in Santa Cruz

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Santa Cruz

Santa Cruz

Cheap flights to Santa Cruz from $222 One Way, $452 Round Trip

$452 return flights and $222 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, May 5 - Tue, May 19
MIA
Miami
VVI
Santa Cruz
$452 Roundtrip, found 1 day ago
$452
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, May 5 from Miami to Santa Cruz, returning Tue, May 19, priced at $452 found 1 day ago
Tue, May 5 - Tue, May 19
MIA
Miami
VVI
Santa Cruz
$500 Roundtrip, found 1 day ago
$500
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, May 5 from Miami to Santa Cruz, returning Tue, May 19, priced at $500 found 1 day ago
Sat, Mar 14 - Sat, Mar 21
MIA
Miami
VVI
Santa Cruz
$520 Roundtrip, found 5 hours ago
$520
Roundtrip
found 5 hours ago
Select Copa flight, departing Sat, Mar 14 from Miami to Santa Cruz, returning Sat, Mar 21, priced at $520 found 5 hours ago
Mon, May 4 - Tue, May 5
IAD
Washington
VVI
Santa Cruz
$526 Roundtrip, found 1 day ago
$526
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, May 4 from Washington to Santa Cruz, returning Tue, May 5, priced at $526 found 1 day ago
Wed, Apr 1 - Sun, Apr 5
MIA
Miami
VVI
Santa Cruz
$528 Roundtrip, found 6 days ago
$528
Roundtrip
found 6 days ago
Select avianca flight, departing Wed, Apr 1 from Miami to Santa Cruz, returning Sun, Apr 5, priced at $528 found 6 days ago
Fri, May 1 - Sat, May 30
MIA
Miami
VVI
Santa Cruz
$536 Roundtrip, found 3 hours ago
$536
Roundtrip
found 3 hours ago
Select Copa flight, departing Fri, May 1 from Miami to Santa Cruz, returning Sat, May 30, priced at $536 found 3 hours ago

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
MIASanta CruzMarch 14 to March 21$520
MIASanta CruzMarch 14 to March 21$520
LAXSanta CruzMarch 14 to March 16$889
LAXSanta CruzMarch 14 to March 16$889
IADSanta CruzMarch 14 to March 19$977
IADSanta CruzMarch 14 to March 19$977
IADSanta CruzMarch 14 to March 19$977
IADSanta CruzMarch 14 to March 19$977
JFKSanta CruzMarch 14 to March 25$985
JFKSanta CruzMarch 14 to March 25$985
MADSanta CruzMarch 14 to March 21$1,343
MADSanta CruzMarch 14 to March 21$1,343
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$136 nightly
The price is $136 total per night from Mar 29 to Mar 30
$136 total
Mar 29 - Mar 30
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (364 reviews)
Yes

Reviewed on Mar 8, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Dr Victor Pinto, Equipetrol Santa Cruz
Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...
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Opens in a new windowHotel LP Equipetrol
Yotau All Suites Hotel

Yotau All Suites Hotel

3.5 out of 5
Av. San Martin No. 7 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...
7/10 Good! (76 reviews)
My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom

Reviewed on Aug 3, 2025

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Opens in a new windowYotau All Suites Hotel
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Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3 out of 5
Av.Ejercito Nacional 290 Santa Cruz
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...
8/10 Very Good! (284 reviews)
Awesome hotel

Reviewed on Feb 6, 2026

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Opens in a new windowHotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz Apartment Hotels

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (100 reviews)
Place is clean , safe area , walking distance to shops

Reviewed on Mar 10, 2026

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Opens in a new windowApart Hotel Premium Suites Santa Cruz
Apartamento Irala

Apartamento Irala

3 out of 5
Calle Prolongancion Cochabamba, S/N Santa Cruz
Book a stay at this spa apartment in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Blacutt Square and Museo de Historia ...
8/10 Very Good! (1 review)
Good location. Building is new. Security is good. Condo unit is spacious for 2 people. Quiet environment. Responsive and reliable owner. Air-conditioning in bedroom only which is still acceptable.

Reviewed on Apr 16, 2019

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Opens in a new windowApartamento Irala
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
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Opens in a new windowBuganvillas Hotel Suites & Spa
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Casa por Temporadas

Casa por Temporadas

3.5 out of 5
Avenida Cristo Redentor Santa Cruz
Stay at this vacation home in Santa Cruz. Enjoy free WiFi, free parking, and an airport shuttle (surcharge). Popular attractions Play Land Amusement Park and ...
10/10 Exceptional! (1 review)
Great place to stay, great attention
The owners were happy to answer all our questions by email before our arrival. The pool was very nice but know that it has no shallow end. The pool table and air hockey table were nice additions, especially if it happens to rain while you are there. The owners know a great taxi driver if you don't ...

Reviewed on Sep 21, 2016

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Opens in a new windowCasa por Temporadas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Santa Cruz Accommodation Deals

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
$122 nightly
The price is $122 total per night from Apr 10 to Apr 11
$122 total
Apr 10 - Apr 11
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
9/10 Wonderful! (420 reviews)
Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options.

Reviewed on Feb 5, 2026

Opens in a new windowCamino Real Hotel
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
$55 nightly
The price is $55 total per night from Mar 13 to Mar 14
$55 total
Mar 13 - Mar 14
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.6/10 Exceptional! (95 reviews)
Good

Reviewed on Mar 8, 2026

Opens in a new windowIbis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$136 nightly
The price is $136 total per night from Mar 29 to Mar 30
$136 total
Mar 29 - Mar 30
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (364 reviews)
Yes

Reviewed on Mar 8, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
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Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
$106 nightly
The price is $106 total per night from Mar 27 to Mar 28
$106 total
Mar 27 - Mar 28
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (219 reviews)
Mattress was hard, pillows flattened, no microwave and fridge was not cooling. Other than that, the personnel were 5 stars, friendly attentive and respectful.

Reviewed on Mar 1, 2026

Opens in a new windowMarriott Santa Cruz de la Sierra Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
$136 nightly
The price is $136 total per night from Mar 29 to Mar 30
$136 total
Mar 29 - Mar 30
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (364 reviews)
Yes

Reviewed on Mar 8, 2026

Opens in a new windowLos Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (100 reviews)
Place is clean , safe area , walking distance to shops

Reviewed on Mar 10, 2026

Get rates
Opens in a new windowApart Hotel Premium Suites Santa Cruz
Buganvillas Hotel Suites & Spa
Great for families

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901 Santa Cruz
Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Families like: Kids pool, cribs, rollaway beds, outdoor tennis courts

Get rates
Opens in a new windowBuganvillas Hotel Suites & Spa
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Camino Real Hotel
Great for families

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
$122 nightly
The price is $122 total per night from Apr 10 to Apr 11
$122 total
Apr 10 - Apr 11
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
9/10 Wonderful! (420 reviews)

Families like: Kids pool, waterslide, playground, babysitting

Travelers say...
Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options.

Reviewed on Feb 5, 2026

Opens in a new windowCamino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark or similar
  • 4 people
Chevrolet Spark
Economy Chevrolet Spark

Compact

Ford Focus or similar
  • 4 people
Ford Focus
Compact Ford Focus

Midsize

Toyota Corolla or similar
  • 5 people
Toyota Corolla
Midsize Toyota Corolla

SUV

Jeep Compass or similar
  • 5 people
Jeep Compass
SUV Jeep Compass

Santa Cruz

Orbitz is your one stop for guaranteed low prices on Santa Cruz flights, as well as budget deals on hotels and rental cars. Use our state of the art mobile tools to get great deals and constant updates on the status of your trip.

Save Big On Car Rentals Too

Orbitz will find you discount air fare for flights to Santa Cruz and you can rent a car at the same time. With Orbitzyou will get a discount on the rental and have your car waiting for you when you land.

Get Free Travel Advice By Calling the Orbitz Hotline

Our experts will make things even easier by helping you to find the best budget flights to Santa Cruz Just call our toll free hotline at 1-800-649-9920 and one of our travel advisors will be happy to assist you with everything from your flight to hotel room.

Book Travel on the Fly with Orbitz on the Go

Our state of the art mobile apps will allow you to book cheap flights to Santa Cruz from your smartphone too. Discount airfare is not all; you can also find mobile-only hotel deals or check the status of your flight using this free app. So, when you’re on the go, why not take Orbitz with you?

Frequently asked questions

Which airlines fly to Santa Cruz?
Book a ticket with one of the 12 airlines that operate services to Viru Viru Intl. Airport (VVI) and gear up for awesome new adventures. This popular airport is a main gateway for exploring Santa Cruz. When it's time to check off this region, these trusted carriers will take you there:

  • BoA - 89 flights to Santa Cruz per month
  • Copa Airlines - 22 flights to Santa Cruz per month
  • Aerolineas Argentinas - 17 flights to Santa Cruz per month

How much is a flight to Santa Cruz?
Travelers from far and wide landed round-trip bargains ranging between $452 and $1,343 this week to Santa Cruz. Starting your trip from Miami (MIA)? The most affordable one-way prices were $222.
How to book the cheapest flight to Santa Cruz?
Scoring cheap flights to Santa Cruz is as simple as booking your ticket with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips worth following:

  • Taking off from or landing at nearby airports can often help you save on airfares. Enter your preferred departure and arrival airports. Next, select the 'Nearby airports' function below to see what your options are.
  • Also, click on the 'Show flexible dates' option and you'll see the prices for days around your chosen departure. You may be able to pick up cheaper flight deals if your travel plans are flexible.
  • To filter your results, hit 'Show options.' You can search based on airlines, seating class, nonstop flights and refundable flights. You can also select your preferred flight times under 'Sort & Filter' to the left.
  • Reserve your fare as soon as you've decided on your travel dates. While you can get lucky on occasion, airline tickets rarely get more affordable as your date of departure gets closer.
  • Consider combining your flights, hotels and car rental into an Orbitz package to get more for your money.
  • If you can, avoid flying in high seasons. Airfares often surge during school breaks, summer and other vacation periods like Easter and Thanksgiving.

What is the best time to book a flight to Santa Cruz?
Generally speaking, January is the best time to book your plane ticket. This is closely followed by February and August. Keep this in mind while you browse for a cheap flight to Santa Cruz.
What day of the week is the cheapest to book a flight to Santa Cruz?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days of the week to book a flight to Santa Cruz. If you want the most competitive airfares, search across those days and you just might land an excellent flight deal.
What is the cheapest day of the week to fly to Santa Cruz?
According to Orbitz data from 2020, you should kick off your trip on a Monday to nab cheap flights to Santa Cruz. Next most inexpensive day? Tuesday. Saturday costs the most. So, depart early in the week if you'd like to score a wallet-friendly fare without paying premium prices.
What is the cheapest month to fly to Santa Cruz?
We won't keep you in suspense — based on Orbitz data, August is generally the cheapest month to fly. Perfect for those who want a weekend getaway or simply escape from it all before the weather changes. The costliest time to fly is the height of summer, with fares at their highest in June.
Which airlines allow free cancellation?
Orbitz makes it a snap to find carriers that offer flexibility. Simply click on "Filter by flexible change policies" when searching for your Santa Cruz flights and boom! We'll show you options that include free cancellation within 24 hours of booking, no change fees and of course, an irresistible low price.
What do I need for the flight to Santa Cruz?
A lengthy flight can be daunting, but it's nothing a little preparation can't solve. We've compiled our top suggestions to ensure your journey is as smooth as possible:

  • In all cases you'll need some identification. How much? This depends on where you're traveling from. When reserving your flight tickets, we suggest to put down the same name, gender and birth date as displayed on your government-issued ID.
  • Take a good book or a laptop crammed with your favorite TV series — it'll help to keep you busy on your journey to Santa Cruz. Or if you'd rather enjoy a nap, a comfy eye mask will block out those bright cabin lights.
  • Long-haul trips can leave you feeling seriously cold, especially if you're flying overnight. If you don't want to curl up to the stranger beside you for warmth, bring your favorite hoodie and some wool socks.

How do I get cheap first-class/business deals to Santa Cruz?
If you think a first or business-class fare is out of your price range, you may want to think again. Here are some practical tips to help you score a premium flight to Santa Cruz for a whole lot less:

  • Be flexible with your travel dates and hold out for deals on business or first-class airfares.
  • Many budget airlines these days have superb business-class seating that doesn't cost an arm and a leg.
  • Take advantage of your airline's loyalty scheme and upgrade your seat. Alternatively, you can try bidding for an upgrade in online auctions.

What is the best time to go to Santa Cruz?
March, August and September are the most popular months to vacation in Santa Cruz. If an average daily high of 90 ºF sounds attractive, book your trip for the start of summer — December 1. Many tourists prefer this time of year for its warmer weather. In the evening, the average temperature falls to 70 ºF.
Travel tips for Santa Cruz

  • Santa Cruz is full of interesting attractions and Plaza 24 de Septiembre is one of them. Lock in a car rental and head there at your convenience.
  • Colinas del Urubo offers plenty of exciting experiences and is a great place to kick off your escape. Whether your scene is cafés, restaurants, art or something else, this city will keep you busy.

More to Explore

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.