$193 Cheap flights to Santa Cruz

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

Top places to visit in Santa Cruz

Cheap flights to Santa Cruz from $193 One Way, $397 Round Trip

$397 return flights and $193 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Deals For This Weekend's Flights

OriginDestinationTravel DatesFlights From*
MIASanta CruzAugust 23 to August 27$540
IADSanta CruzAugust 23 to September 6$584
IADSanta CruzAugust 23 to September 6$584
JFKSanta CruzAugust 22 to September 3$617
LAXSanta CruzAugust 23 to September 2$617
PTYSanta CruzAugust 22 to August 24$718
YVRSanta CruzAugust 23 to November 20$1,684
*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
$131 nightly
The price is $131 total per night from Sep 9 to Sep 10
$131 total
Sep 9 - Sep 10
Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (322 reviews)
"Always an amazing hotel"

Reviewed on Jun 21, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol

Hotel LP Equipetrol

3.5 out of 5
Dr Victor Pinto, Equipetrol, esquina Marcelo Terceros Banzer, Santa Cruz
Stay at this 3.5-star hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are ...
8/10 Very Good! (198 reviews)
"So, the mattress and pillows were not that comfortable, hard. No microwave and the sheets not the size of the bed, smaller. The treatment from the hotel personnel was good."

Reviewed on Feb 21, 2025

Hotel LP Equipetrol
Yotau All Suites Hotel

Yotau All Suites Hotel

3.5 out of 5
Av. San Martin No. 7, Santa Cruz
Stay at this 3.5-star family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...
6.8/10 (75 reviews)
"My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom"

Reviewed on Aug 3, 2025

Yotau All Suites Hotel
Save an average of 15% on thousands of hotels when you're signed in
Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

3 out of 5
Av.Ejercito Nacional 290, (frente Stadium Tahuichi), Santa Cruz
Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...
7.8/10 Good! (280 reviews)
"Clean, friendly staff"

Reviewed on Jun 2, 2024

Hotel LP Santa Cruz Centro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz Apartment Hotels

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45, a 1 cuadra de la Av. San Martin, Santa Cruz
Stay at this 3.5-star business-friendly aparthotel in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle ...
8.4/10 Very Good! (89 reviews)
"The personal was very helpful and they answered very quickly"

Reviewed on May 11, 2025

Apart Hotel Premium Suites Santa Cruz
Apartamento Irala

Apartamento Irala

3 out of 5
Calle Prolongancion Cochabamba, S/N, Edificios Altos del Sur, 1st Floor, Santa Cruz
Stay at this 3-star spa apartment in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Blacutt Square and Museo de Historia ...
"Good location. Building is new. Security is good. Condo unit is spacious for 2 people. Quiet environment. Responsive and reliable owner. Air-conditioning in bedroom only which is still acceptable."

Reviewed on Apr 16, 2019

Apartamento Irala
Buganvillas Hotel Suites & Spa

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901, Santa Cruz
Stay at this 4-star family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
7.4/10 Good! (92 reviews)
"Extremely satisfy with the service that this resort provided to us. Definitely will return back. Follow me on YouTube #TeamWithERVING"

Reviewed on Aug 14, 2021

Buganvillas Hotel Suites & Spa
Save an average of 15% on thousands of hotels when you're signed in
Casa por Temporadas

Casa por Temporadas

3.5 out of 5
Avenida Cristo Redentor, frente al cementerio Las Misiones, Santa Cruz
Stay at this 3.5-star vacation home in Santa Cruz. Enjoy free WiFi, free parking, and an airport shuttle (surcharge). Popular attractions Play Land Amusement ...
Great place to stay, great attention
"The owners were happy to answer all our questions by email before our arrival. The pool was very nice but know that it has no shallow end. The pool table and air hockey table were nice additions, especially if it happens to rain while you are there. The owners know a great taxi driver if you don't ..."

Reviewed on Sep 21, 2016

Casa por Temporadas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Santa Cruz Accommodation Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA, Santa Cruz
$43 nightly
The price is $43 total per night from Sep 3 to Sep 4
$43 total
Sep 3 - Sep 4
Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (51 reviews)
"The"

Reviewed on Jul 28, 2025

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23, At Calle Las Ramblas, Santa Cruz, Santa Cruz
$119 nightly
The price is $119 total per night from Aug 29 to Aug 30
$119 total
Aug 29 - Aug 30
Stay at this 5-star luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...
9/10 Wonderful! (191 reviews)
"all"

Reviewed on Jun 5, 2025

Marriott Santa Cruz de la Sierra Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
$131 nightly
The price is $131 total per night from Sep 9 to Sep 10
$131 total
Sep 9 - Sep 10
Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (322 reviews)
"Always an amazing hotel"

Reviewed on Jun 21, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Save an average of 15% on thousands of hotels when you're signed in
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
$140 nightly
The price is $140 total per night from Sep 15 to Sep 16
$140 total
Sep 15 - Sep 16
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz ...
8.8/10 Excellent! (396 reviews)
Best amenities
"Best amenities in a hotel , but need some upgrades"

Reviewed on Jul 16, 2025

Camino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455, Santa Cruz
$131 nightly
The price is $131 total per night from Sep 9 to Sep 10
$131 total
Sep 9 - Sep 10
Stay at this 3.5-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (322 reviews)
"Always an amazing hotel"

Reviewed on Jun 21, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45, a 1 cuadra de la Av. San Martin, Santa Cruz
Stay at this 3.5-star business-friendly aparthotel in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle ...
8.4/10 Very Good! (89 reviews)
"The personal was very helpful and they answered very quickly"

Reviewed on May 11, 2025

Apart Hotel Premium Suites Santa Cruz
Buganvillas Hotel Suites & Spa
Great for families

Buganvillas Hotel Suites & Spa

4 out of 5
Av. Roca y Coronado No. 901, Santa Cruz
Stay at this 4-star family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...
7.4/10 Good! (92 reviews)

Families like: Kids pool, cribs, rollaway beds, outdoor tennis courts

Travelers say...
"Extremely satisfy with the service that this resort provided to us. Definitely will return back. Follow me on YouTube #TeamWithERVING"

Reviewed on Aug 14, 2021

Buganvillas Hotel Suites & Spa
Save an average of 15% on thousands of hotels when you're signed in
Camino Real Hotel
Great for families

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo, Equipetrol Norte, Santa Cruz
$140 nightly
The price is $140 total per night from Sep 15 to Sep 16
$140 total
Sep 15 - Sep 16
Stay at this 4.5-star luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz ...
8.8/10 Excellent! (396 reviews)

Families like: Kids pool, waterslide, playground, babysitting

Best amenities
"Best amenities in a hotel , but need some upgrades"

Reviewed on Jul 16, 2025

Camino Real Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Santa Cruz

When you plan to buy tickets for flights to Santa Cruz, you don’t have to look any further than Orbitz! We offer bargain rates and low fares on thousands of flights.

Reliable Customer Service

Along with our low prices, Orbitz is well known for exceptional customer care. We make it simple to find the best Santa Cruz flights for you. If you need to cancel your booking or change your flight plans, simply contact our Customer Service department to make any adjustments.

Bargain Tickets for Santa Cruz Flights

Orbitz offers deeply discounted flights to Santa Cruz, and we provide the resources to research your travel destination and plan your complete itinerary.

Use Orbitz to Earn Points with Your Frequent Flyer Program

Saving your frequent flyer miles for your flights to Santa Cruz? You can use Orbitz to make your budget ticket reservation for all your flights and still earn points or miles on your frequent flyer program! Just enter your program account number while you’re booking your ticket to have your points added automatically, every time you book with Orbitz.

Convenient Travel Planning Services

If you like the ease of making your travel plans on the move, you’ll love the free Orbitz apps for iPhones, iPads, and Android devices. You can use these apps to review your travel reservations or make a change to your itinerary. Orbitz also offers additional travel assistance such as free mobile alerts that keep you up-to-date about sudden changes to your upcoming flights. You can also browse Orbitz easily on your smartphone by using the mobile version of the website to find budget Santa Cruz flights.

Frequently asked questions

Which airlines fly to Santa Cruz?
Book a ticket with one of the 14 airlines that operate services to Viru Viru Intl. Airport (VVI) and gear up for awesome new adventures. This popular airport is a main gateway for exploring Santa Cruz. When it's time to check off this region, these trusted carriers will take you there:

  • BoA - 89 flights to Santa Cruz per month
  • Copa Airlines - 22 flights to Santa Cruz per month
  • Aerolineas Argentinas - 17 flights to Santa Cruz per month

How much is a flight to Santa Cruz?
Travelers from far and wide landed round-trip bargains ranging between $397 and $1,684 this week to Santa Cruz. Starting your trip from Fort Lauderdale (FLL)? The most affordable one-way prices were $193.
How to book the cheapest flight to Santa Cruz?
Scoring cheap flights to Santa Cruz is as simple as booking your ticket with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips worth following:

  • Taking off from or landing at nearby airports can often help you save on airfares. Enter your preferred departure and arrival airports. Next, select the 'Nearby airports' function below to see what your options are.
  • Also, click on the 'Show flexible dates' option and you'll see the prices for days around your chosen departure. You may be able to pick up cheaper flight deals if your travel plans are flexible.
  • To filter your results, hit 'Show options.' You can search based on airlines, seating class, nonstop flights and refundable flights. You can also select your preferred flight times under 'Sort & Filter' to the left.
  • Reserve your fare as soon as you've decided on your travel dates. While you can get lucky on occasion, airline tickets rarely get more affordable as your date of departure gets closer.
  • Consider combining your flights, hotels and car rental into an Orbitz package to get more for your money.
  • If you can, avoid flying in high seasons. Airfares often surge during school breaks, summer and other vacation periods like Easter and Thanksgiving.

What is the best time to book a flight to Santa Cruz?
Generally speaking, January is the best time to book your plane ticket. This is closely followed by February and August. Keep this in mind while you browse for a cheap flight to Santa Cruz.
What day of the week is the cheapest to book a flight to Santa Cruz?
Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days of the week to book a flight to Santa Cruz. If you want the most competitive airfares, search across those days and you just might land an excellent flight deal.
What is the cheapest day of the week to fly to Santa Cruz?
According to Orbitz data from 2020, you should kick off your trip on a Monday to nab cheap flights to Santa Cruz. Next most inexpensive day? Tuesday. Saturday costs the most. So, depart early in the week if you'd like to score a wallet-friendly fare without paying premium prices.
What is the cheapest month to fly to Santa Cruz?
We won't keep you in suspense — based on Orbitz data, August is generally the cheapest month to fly. Perfect for those who want a weekend getaway or simply escape from it all before the weather changes. The costliest time to fly is the height of summer, with fares at their highest in June.
Which airlines allow free cancellation?
Orbitz makes it a snap to find carriers that offer flexibility. Simply click on "Filter by flexible change policies" when searching for your Santa Cruz flights and boom! We'll show you options that include free cancellation within 24 hours of booking, no change fees and of course, an irresistible low price.
What do I need for the flight to Santa Cruz?
A lengthy flight can be daunting, but it's nothing a little preparation can't solve. We've compiled our top suggestions to ensure your journey is as smooth as possible:

  • In all cases you'll need some identification. How much? This depends on where you're traveling from. When reserving your flight tickets, we suggest to put down the same name, gender and birth date as displayed on your government-issued ID.
  • Take a good book or a laptop crammed with your favorite TV series — it'll help to keep you busy on your journey to Santa Cruz. Or if you'd rather enjoy a nap, a comfy eye mask will block out those bright cabin lights.
  • Long-haul trips can leave you feeling seriously cold, especially if you're flying overnight. If you don't want to curl up to the stranger beside you for warmth, bring your favorite hoodie and some wool socks.

How do I get cheap first-class/business deals to Santa Cruz?
If you think a first or business-class fare is out of your price range, you may want to think again. Here are some practical tips to help you score a premium flight to Santa Cruz for a whole lot less:

  • Be flexible with your travel dates and hold out for deals on business or first-class airfares.
  • Many budget airlines these days have superb business-class seating that doesn't cost an arm and a leg.
  • Take advantage of your airline's loyalty scheme and upgrade your seat. Alternatively, you can try bidding for an upgrade in online auctions.

What is the best time to go to Santa Cruz?
March, August and September are the most popular months to vacation in Santa Cruz. If an average daily high of 90 ºF sounds attractive, book your trip for the start of summer — December 1. Many tourists prefer this time of year for its warmer weather. In the evening, the average temperature falls to 70 ºF.
Travel tips for Santa Cruz

  • Santa Cruz is full of interesting attractions and Plaza 24 de Septiembre is one of them. Lock in a car rental and head there at your convenience.
  • Colinas del Urubo offers plenty of exciting experiences and is a great place to kick off your escape. Whether your scene is cafés, restaurants, art or something else, this city will keep you busy.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.