$265 Cheap flights to Santa Cruz

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Top places to visit in Santa Cruz

A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz

Cheap flights to Santa Cruz from $265 One Way, $572 Round Trip

$572 return flights and $265 one-way flights to Santa Cruz were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jul 17 - Sat, Jul 24

MIA

Miami

VVI

Santa Cruz

$572

Roundtrip

found 1 day ago

Sat, Jul 17 - Sat, Jul 24

MIA

Miami

VVI

Santa Cruz

$577

Roundtrip

found 1 day ago

Sat, Sep 5 - Fri, Sep 25

MIA

Miami

VVI

Santa Cruz

$578

Roundtrip

found 22 hours ago

Wed, Nov 18 - Mon, Nov 23

BOS

Boston

VVI

Santa Cruz

$588

Roundtrip

found 5 days ago

Tue, Sep 15 - Tue, Sep 22

FLL

Fort Lauderdale

VVI

Santa Cruz

$590

Roundtrip

found 1 day ago

Sat, Sep 5 - Fri, Sep 25

MIA

Miami

VVI

Santa Cruz

$592

Roundtrip

found 22 hours ago

Deals For This Weekend's Flights

Origin	Destination	Travel Dates	Flights From*
MIA	Santa Cruz	September 12 to September 25	$615
MIA	Santa Cruz	September 12 to September 25	$615
PTY	Santa Cruz	September 11 to September 13	$692
PTY	Santa Cruz	September 11 to September 13	$692
JFK	Santa Cruz	September 11 to September 30	$727
LAX	Santa Cruz	September 13 to September 15	$769
LAX	Santa Cruz	September 13 to September 15	$769
IAD	Santa Cruz	September 12 to September 23	$827
IAD	Santa Cruz	September 12 to September 23	$827
IAD	Santa Cruz	September 12 to September 23	$827
IAD	Santa Cruz	September 12 to September 23	$827
CCS	Santa Cruz	September 12 to October 17	$1,280
CCS	Santa Cruz	September 12 to October 17	$1,280
MAD	Santa Cruz	September 13 to September 30	$2,362
MAD	Santa Cruz	September 13 to September 30	$2,362

*Prices include taxes and fees

Find The Perfect Hotel For After Your Flight

Score Epic Santa Cruz Accommodation Deals

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$127 nightly

$127 total

Oct 4 - Oct 5

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (404 reviews)

"Breakfast is wonderful"

Reviewed on Sep 1, 2026

Hotel LP Equipetrol

Dr Victor Pinto, Equipetrol Santa Cruz

$41 nightly

$41 total

Sep 6 - Sep 7

Stay at this hotel in Santa Cruz. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...

8.2/10 Very Good! (210 reviews)

"El cuarto agradable, pero faltó servicio de ayuda para subir y bajar maletas, también servicio adecuado de taxi para moverse en Santa Cruz"

Reviewed on Jul 14, 2026

Yotau All Suites Hotel

Av. San Martin No. 7 Santa Cruz

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Patio Design LifeStyle Center ...

7/10 Good! (76 reviews)

"My issue was because the property inside the room was old needs a lot maintenance I found a underwear en the cabinet in the bathroom"

Reviewed on Aug 3, 2025

Get rates

Save an average of 15% on thousands of hotels when you're signed in

Hotel LP Santa Cruz Centro

Av.Ejercito Nacional 290 Santa Cruz

$40 nightly

$40 total

Oct 3 - Oct 4

Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Ramon Tahuichi Aguilera ...

8/10 Very Good! (285 reviews)

"Awesome hotel"

Reviewed on Feb 6, 2026

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Our Top Santa Cruz Apartment Hotels

Apart Hotel Premium Suites Santa Cruz

Calle Las Begonias Nro 45 Santa Cruz

$25 nightly

$25 total

Oct 4 - Oct 5

Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...

8.6/10 Excellent! (104 reviews)

"Good location"

Reviewed on Aug 8, 2026

Apartamento Irala

Calle Prolongancion Cochabamba, S/N Santa Cruz

Book a stay at this spa apartment in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Blacutt Square and Museo de Historia ...

8/10 Very Good! (1 review)

"Good location. Building is new. Security is good. Condo unit is spacious for 2 people. Quiet environment. Responsive and reliable owner. Air-conditioning in bedroom only which is still acceptable."

Reviewed on Apr 16, 2019

Get rates

Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901 Santa Cruz

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Get rates

Save an average of 15% on thousands of hotels when you're signed in

Casa por Temporadas

Avenida Cristo Redentor Santa Cruz

Stay at this vacation home in Santa Cruz. Enjoy free WiFi, free parking, and an airport shuttle (surcharge). Popular attractions Play Land Amusement Park and ...

10/10 Exceptional! (1 review)

Great place to stay, great attention

"The owners were happy to answer all our questions by email before our arrival. The pool was very nice but know that it has no shallow end. The pool table and air hockey table were nice additions, especially if it happens to rain while you are there. The owners know a great taxi driver if you don't ..."

Reviewed on Sep 21, 2016

Get rates

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Score Epic Santa Cruz Accommodation Deals

Ibis Santa Cruz DE LA Sierra

AVENIDA CRISTOBAL DE MENDOZA Santa Cruz

$36 nightly

$36 total

Oct 1 - Oct 2

Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...

9.4/10 Exceptional! (137 reviews)

"La ubicación es muy buena y puedes caminar por la zona"

Reviewed on Aug 31, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$127 nightly

$127 total

Oct 4 - Oct 5

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (404 reviews)

"Breakfast is wonderful"

Reviewed on Sep 1, 2026

Marriott Santa Cruz de la Sierra Hotel

4to Anillo Entre Radial 23 Santa Cruz Santa Cruz

$106 nightly

$106 total

Oct 2 - Oct 3

Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...

9/10 Wonderful! (247 reviews)

"Staff was super as well as how clean the room was."

Reviewed on Aug 23, 2026

Save an average of 15% on thousands of hotels when you're signed in

Camino Real Hotel

Av. San Martín y 4to. Anillo Santa Cruz

$131 nightly

$131 total

Oct 4 - Oct 5

Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

$127 nightly

$127 total

Oct 4 - Oct 5

Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...

9/10 Wonderful! (404 reviews)

"Breakfast is wonderful"

Reviewed on Sep 1, 2026

Apart Hotel Premium Suites Santa Cruz

Calle Las Begonias Nro 45 Santa Cruz

$25 nightly

$25 total

Oct 4 - Oct 5

Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...

8.6/10 Excellent! (104 reviews)

"Good location"

Reviewed on Aug 8, 2026

Buganvillas Hotel Suites & Spa

Av. Roca y Coronado No. 901 Santa Cruz

Book a stay at this family-friendly hotel in Santa Cruz. Enjoy breakfast (surcharge), room service, and a fitness center. Popular attractions Parque Ecológico ...

Families like: Kids pool, cribs, rollaway beds, outdoor tennis courts

Get rates

Save an average of 15% on thousands of hotels when you're signed in

Camino Real Hotel

Av. San Martín y 4to. Anillo Santa Cruz

$131 nightly

$131 total

Oct 4 - Oct 5

Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Need a Car For After Your Flight?

Economy

Chevrolet Spark

4 people

Compact

Ford Focus

4 people

Midsize

Toyota Corolla

5 people

SUV

Jeep Compass

5 people

Santa Cruz

Save more on flights to Santa Cruz while making top-quality travel arrangements. At Orbitz we provide access to low cost flights, hotel lodgings and other discounts, along with superior customer service and an unbeatable satisfaction guarantee.

Compare And Book Discount Flights to Santa Cruz

Now it is easier than ever to find a discount Santa Cruz flight. Orbitz users can compare airfares for both international and domestic flights and can quickly determine the best hotels and car rental companies to use. You may also check out hotel and other reviews along with a number of travel tips, making your visit to an unfamiliar destination enjoyable and hassle-free.

Use Your Mobile Phone To Secure A Low Cost Flight To Santa Cruz

We now offer free apps for the most commonly used mobile devices. You can use your mobile phone to share relevant information pertaining to your trips, view images of local lodgings and take advantage of hotel and car rental discounts that may be available only to mobile device users.

Boost Your Frequent Flyer Rewards

You even retain your ability to earn frequent flier points and rewards when purchasing your tickets with Orbitz for Santa Cruz flights. Enter your frequent flyer information into your Orbitz profile to start earning rewards.

You will find that Orbitz is a very low cost, yet very effective travel planner. Free updates via your mobile phone device will help to keep you and all relevant parties informed of important flight updates. With access to unbeatable sales on all travel essentials, Orbitz makes booking an affordable flight to Santa Cruz a breeze.

Frequently asked questions

Which airlines fly to Santa Cruz?

Book a ticket with one of the 12 airlines that operate services to Viru Viru Intl. Airport (VVI) and gear up for awesome new adventures. This popular airport is a main gateway for exploring Santa Cruz. When it's time to check off this region, these trusted carriers will take you there:

BoA - 89 flights to Santa Cruz per month
Copa Airlines - 22 flights to Santa Cruz per month
Aerolineas Argentinas - 17 flights to Santa Cruz per month

How much is a flight to Santa Cruz?

Travelers from far and wide landed round-trip bargains ranging between $572 and $2,362 this week to Santa Cruz. Starting your trip from Miami (MIA)? The most affordable one-way prices were $265.

How to book the cheapest flight to Santa Cruz?

Scoring cheap flights to Santa Cruz is as simple as booking your ticket with Orbitz. But if you'd love to make sure you're walking away with the best flight deals around, here are some tips worth following:

Taking off from or landing at nearby airports can often help you save on airfares. Enter your preferred departure and arrival airports. Next, select the 'Nearby airports' function below to see what your options are.
Also, click on the 'Show flexible dates' option and you'll see the prices for days around your chosen departure. You may be able to pick up cheaper flight deals if your travel plans are flexible.
To filter your results, hit 'Show options.' You can search based on airlines, seating class, nonstop flights and refundable flights. You can also select your preferred flight times under 'Sort & Filter' to the left.
Reserve your fare as soon as you've decided on your travel dates. While you can get lucky on occasion, airline tickets rarely get more affordable as your date of departure gets closer.
Consider combining your flights, hotels and car rental into an Orbitz package to get more for your money.
If you can, avoid flying in high seasons. Airfares often surge during school breaks, summer and other vacation periods like Easter and Thanksgiving.

What is the best time to book a flight to Santa Cruz?

Generally speaking, January is the best time to book your plane ticket. This is closely followed by February and August. Keep this in mind while you browse for a cheap flight to Santa Cruz.

What day of the week is the cheapest to book a flight to Santa Cruz?

Typically, Tuesdays, Wednesdays and Saturdays are the cheapest days of the week to book a flight to Santa Cruz. If you want the most competitive airfares, search across those days and you just might land an excellent flight deal.

What is the cheapest day of the week to fly to Santa Cruz?

According to Orbitz data from 2020, you should kick off your trip on a Monday to nab cheap flights to Santa Cruz. Next most inexpensive day? Tuesday. Saturday costs the most. So, depart early in the week if you'd like to score a wallet-friendly fare without paying premium prices.

What is the cheapest month to fly to Santa Cruz?

We won't keep you in suspense — based on Orbitz data, August is generally the cheapest month to fly. Perfect for those who want a weekend getaway or simply escape from it all before the weather changes. The costliest time to fly is the height of summer, with fares at their highest in June.

Which airlines allow free cancellation?

Orbitz makes it a snap to find carriers that offer flexibility. Simply click on "Filter by flexible change policies" when searching for your Santa Cruz flights and boom! We'll show you options that include free cancellation within 24 hours of booking, no change fees and of course, an irresistible low price.

What do I need for the flight to Santa Cruz?

A lengthy flight can be daunting, but it's nothing a little preparation can't solve. We've compiled our top suggestions to ensure your journey is as smooth as possible:

In all cases you'll need some identification. How much? This depends on where you're traveling from. When reserving your flight tickets, we suggest to put down the same name, gender and birth date as displayed on your government-issued ID.
Take a good book or a laptop crammed with your favorite TV series — it'll help to keep you busy on your journey to Santa Cruz. Or if you'd rather enjoy a nap, a comfy eye mask will block out those bright cabin lights.
Long-haul trips can leave you feeling seriously cold, especially if you're flying overnight. If you don't want to curl up to the stranger beside you for warmth, bring your favorite hoodie and some wool socks.

How do I get cheap first-class/business deals to Santa Cruz?

If you think a first or business-class fare is out of your price range, you may want to think again. Here are some practical tips to help you score a premium flight to Santa Cruz for a whole lot less:

Be flexible with your travel dates and hold out for deals on business or first-class airfares.
Many budget airlines these days have superb business-class seating that doesn't cost an arm and a leg.
Take advantage of your airline's loyalty scheme and upgrade your seat. Alternatively, you can try bidding for an upgrade in online auctions.

What is the best time to go to Santa Cruz?

March, August and September are the most popular months to vacation in Santa Cruz. If an average daily high of 90 ºF sounds attractive, book your trip for the start of summer — December 1. Many tourists prefer this time of year for its warmer weather. In the evening, the average temperature falls to 70 ºF.

Travel tips for Santa Cruz

Santa Cruz is full of interesting attractions and Plaza 24 de Septiembre is one of them. Lock in a car rental and head there at your convenience.
Colinas del Urubo offers plenty of exciting experiences and is a great place to kick off your escape. Whether your scene is cafés, restaurants, art or something else, this city will keep you busy.

More to Explore

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.