Florence County Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save 10% or more on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Top cities in Florence County

Vacation RentalsVacation Rentals
Vacation RentalsVacation Rentals

Florence

Florence

Florence County Vacation Rentals

Perfect Stop • Near I-95, Downtown & Civic Center and Darlington

Perfect Stop • Near I-95, Downtown & Civic Center and Darlington

2 out of 5
Florence SC
$242 nightly
The price is $271 total per night
$271 total
Dec 29 - Dec 30
Total with taxes and fees
Guests staying at this vacation home enjoy a hot tub and laundry facilities.
Hot Tub
Washer
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Florence SC
$235 nightly
The price is $263 total per night
$263 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
At this vacation home, guests have access to features like laundry facilities. This smoke-free vacation home also has a garden.
Kitchen
Washer
Perfect Get-Away In The Heart Of Downtown Florence

Perfect Get-Away In The Heart Of Downtown Florence

2 out of 5
Florence SC
At this vacation home, guests have access to features like laundry facilities.
Washer
Dryer
Great Home in the Greater Florence Area

Great Home in the Greater Florence Area

Timmonsville SC
At this vacation home, guests have access to features like laundry facilities. This smoke-free vacation home also has a garden.
Kitchen
Washer
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Florence SC
$206 nightly
The price is $231 total per night
$231 total
Dec 22 - Dec 23
Total with taxes and fees
Guests staying at this vacation home have access to laundry facilities, a garden, and barbecue grills.
3-bedroom mobile home in peaceful Florence with AC, WiFi

3-bedroom mobile home in peaceful Florence with AC, WiFi

Florence SC
At 3-bedroom mobile home in peaceful Florence with AC, WiFi, guests have access to features like laundry facilities.
Washer
Air conditioning
3-bedroom mobile home in Florence, SC

3-bedroom mobile home in Florence, SC

Florence SC
At 3-bedroom mobile home in Florence, SC, guests have access to features like laundry facilities.
Washer
Air conditioning
Pineapple House: Historic. Southern Charm. Walk Downtown.

Pineapple House: Historic. Southern Charm. Walk Downtown.

Florence SC
Guests staying at this vacation home have access to laundry facilities, a garden, and barbecue grills.
Kitchen
Washer
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Florence SC
At this vacation home, guests have access to features like laundry facilities.
Kitchen
Washer
Family Retreat for vacations, weddings, family reunions and corporate retreats.

Family Retreat for vacations, weddings, family reunions and corporate retreats.

Florence SC
At this cabin, guests have access to features like laundry facilities. This family-friendly cabin also has barbecue grills.
Kitchen
Washer
Tasteful and peaceful unit near downtown

Tasteful and peaceful unit near downtown

Florence SC
At this apartment, guests have access to features like laundry facilities.
Hickory Haven 3Br Elegant Downtown Hidden Gem

Hickory Haven 3Br Elegant Downtown Hidden Gem

Florence SC
At this vacation home, guests have access to an arcade/game room, laundry facilities, and barbecue grills.
Kitchen
Washer
3-story Home w/ Private Backyard in Florence!

3-story Home w/ Private Backyard in Florence!

3 out of 5
Florence SC
At this cottage, guests have access to free WiFi in public areas. If you drive, take advantage of free parking.
Luxury stay at 4 bedroom house

Luxury stay at 4 bedroom house

Florence SC
Guests staying at this vacation home enjoy a hot tub, laundry facilities, and a garden. This smoke-free vacation home also has barbecue grills.
Hot Tub
Kitchen
Secret SC Cabin on 100 acres Hot Tub Large Pond

Secret SC Cabin on 100 acres Hot Tub Large Pond

Marion SC
$425 nightly
The price is $463 total per night
$463 total
Dec 22 - Dec 23
Total with taxes and fees
Guests staying at this cabin enjoy a water park, a hot tub, and laundry facilities. This family-friendly cabin also has barbecue grills.
Hot Tub
Kitchen
2023 camper ready for rent at your campground request!

2023 camper ready for rent at your campground request!

Conway SC
$229 nightly
The price is $256 total per night
$256 total
Dec 22 - Dec 23
Total with taxes and fees
Guests staying at this vacation home enjoy features like an outdoor pool. Transportation is made easy with limo/town car service.
Pool
Kitchen
Historic Conway Lofts

Historic Conway Lofts

3 out of 5
300 Laurel Street Conway SC
Free parking is included with your stay.
Parking included
Free WiFi
BEAUTIFULLY RENOVATED CONDO IN LEGENDS GOLF RESORT

BEAUTIFULLY RENOVATED CONDO IN LEGENDS GOLF RESORT

Myrtle Beach SC
$233 nightly
The price is $261 total per night
$261 total
Jan 7 - Jan 8, 2026
Total with taxes and fees
Guests of this condo enjoy features like an outdoor pool, a hot tub, and laundry facilities.
Pool
Hot Tub
Don't see what you're looking for?
See all available properties in Florence County
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotel Options in Florence County

    Comfort Inn & Suites Florence Center Area

    Comfort Inn & Suites Florence Center Area

    527 Woody Jones Blvd Florence SC
    $97 nightly
    The price is $109 total per night from Jan 4 to Jan 5
    $109 total
    Jan 4 - Jan 5, 2026
    Total with taxes and fees
    9/10 Wonderful! (1,169 reviews)
    Park Inn by Radisson Florence, SC

    Park Inn by Radisson Florence, SC

    1729 Mandeville Road Florence SC
    $85 nightly
    The price is $95 total per night from Dec 23 to Dec 24
    $95 total
    Dec 23 - Dec 24
    Total with taxes and fees
    8.8/10 Excellent! (2,195 reviews)
    Howard Johnson by Wyndham Florence

    Howard Johnson by Wyndham Florence

    2038 W Lucas Street Florence SC
    $62 nightly
    The price is $70 total per night from Dec 22 to Dec 23
    $70 total
    Dec 22 - Dec 23
    Total with taxes and fees
    8.6/10 Excellent! (2,506 reviews)

Orbitz makes it easy to find vacation rentals in Florence County 

🏠 What is the best price for a Florence County vacation rental?


Florence County rentals range between $70 and $463 per night. At Orbitz, we have a vacation rental for every budget.


🏠 What types of vacation rentals in Florence County can I rent?


Choose from apartments to beautifully decorated vacation homes, condo resorts or even B&Bs or motels for your next Florence County getaway. Orbitz filters your search results so you can find the best Florence County vacation rental for you. We have tons of options.


🏠 Are cancellations free on Florence County vacation rentals with Orbitz?


You may be able to cancel or amend your Florence County vacation rental booking free of charge before a pre-agreed deadline. Make sure to check the terms of cancellation before you book—so you know exactly where you stand. 


🏠 How do I find the best vacation rental deals in Florence County?


Enter your travel dates, and we’ll do the rest. You can then browse our exciting deals and all the tempting vacation rentals we have on offer in Florence County by filtering your search by amenities, prices, and property types and look at customers ratings to help you pick.


🏠 How do I cancel my vacation rental booking through Orbitz


Vacation rentals have slightly different rules to other bookings on Orbitz. Usually, you need to contact your property manager, you may be able to get a full refund before the cancellation date. Click My TripsOpens in a new window on your Orbitz account page to find the right information contact. If you need more help, visit our Customer ServiceOpens in a new window page. 


🏠 What are the advantages of booking a vacation rental in Florence County?


When you book a Florence County vacation rental, you have the privacy of home and can add on those luxury amenities of a hotel. Filter your vacation rental results to find a place with a hot tub or pool, games rooms or large patio with a barbecue. With so much choice on offer, it’s easy to plan the perfect trip with Orbitz. 


🏠 Where can I find vacation rentals in Florence County?


Escape back to nature and check out some of the smaller towns. You’ll find great vacation rentals right across Florence County—with plenty of hidden gems. We also have plenty of inventory in Florence County main cities and near popular attraction spots.


🏠 Why should I book my Florence County vacation rental with Orbitz?


At Orbitz, we search the market for the best accommodation, flights, and car rental deals, so you don’t have to. We’ll help you build your dream Florence County vacation. With plenty of vacation rentals on offer, you can be sure to find the one that’s right for you in just a few clicks. 


More to Explore