Cheap flights from TYS to COU (McGhee Tyson to Columbia Regional)
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Cheap Flights from TYS to COU starting at $258 One Way, $600 Round Trip
Prices starting at $600 for return flights and $258 for one-way flights to Columbia Regional were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
TYS
Knoxville
COU
Columbia
$600 Roundtrip, found 5 days ago
$600
Roundtrip
found 5 days ago
TYS
Knoxville
COU
Columbia
$616 Roundtrip, found 5 days ago
$616
Roundtrip
found 5 days ago
TYS
Knoxville
COU
Columbia
$622 Roundtrip, found 5 days ago
$622
Roundtrip
found 5 days ago
TYS
Knoxville
COU
Columbia
$636 Roundtrip, found 5 days ago
$636
Roundtrip
found 5 days ago
TYS
Knoxville
COU
Columbia
$653 Roundtrip, found 5 days ago
$653
Roundtrip
found 5 days ago
Hotel Ideas near Columbia Regional
Airport Hotels near Columbia Regional
Whispering Woods Hideaway ~ Large Home ~ 85 in TV
Columbia MO
$453 nightly
The price is $476 total per night from Aug 21 to Aug 22
$476 total
Aug 21 - Aug 22
Total with taxes and fees
Stay at this vacation home in Columbia. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Rock Bridge Memorial State Park and Three Creeks ...
10/10 Exceptional! (4 reviews)
"Great place to stay for our basketball team. We had plenty of room to sleep and to eat."
Reviewed on Jun 15, 2026
3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena
Columbia MO
$341 nightly
The price is $359 total per night from Sep 1 to Sep 2
$359 total
Sep 1 - Sep 2
Total with taxes and fees
Stay at this vacation home in Columbia. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Gans Creek Conservation Area and Philips Lake are ...
Tru By Hilton Columbia South
4401 S Ponderosa Street Columbia MO
$85 nightly
The price is $97 total per night from Aug 23 to Aug 24
$97 total
Aug 23 - Aug 24
Total with taxes and fees
Stay at this hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Mizzou Arena and A. Perry Philips Park are located ...
8.8/10 Excellent! (98 reviews)
"The front desk staff is unbelievably friendly and helpful! Great way to start off a stay. The property is new and clean. Room was clean and comfortable. Great value in a nice location."
Reviewed on Aug 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels In Columbia
Drury Plaza Hotel Columbia East
3100 Interstate 70 Dr. SE Columbia MO
$94 nightly
The price is $106 total per night from Aug 23 to Aug 24
$106 total
Aug 23 - Aug 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the breakfast and ...
Best Western Plus Columbia Inn
2904 Clark Lane Columbia MO
$82 nightly
The price is $92 total per night from Aug 23 to Aug 24
$92 total
Aug 23 - Aug 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Baymont by Wyndham Columbia, MO
2500 I 70 Dr Sw Columbia MO
$63 nightly
The price is $71 total per night from Aug 24 to Aug 25
$71 total
Aug 24 - Aug 25
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
8.2/10 Very Good! (961 reviews)
"It was a really nice hotel. Well kept everyone was friendly."
Reviewed on Aug 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Columbia Hotels With Airport Transportation
Courtyard by Marriott Columbia Missouri
3301 LeMone Industrial Blvd Columbia MO
$110 nightly
The price is $124 total per night from Aug 23 to Aug 24
$124 total
Aug 23 - Aug 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Mizzou Arena and Walters-Boone ...
Stoney Creek Hotel Columbia
2601 S Providence Rd Columbia MO
$114 nightly
The price is $129 total per night from Sep 13 to Sep 14
$129 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the breakfast and the pool in ...
8.6/10 Excellent! (1,378 reviews)
"I had stains on my bedspread and holes in the the"
Reviewed on Aug 15, 2026
The Broadway Columbia - a DoubleTree by Hilton
1111 E Broadway Columbia MO
$130 nightly
The price is $148 total per night from Aug 28 to Aug 29
$148 total
Aug 28 - Aug 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Low Priced Columbia Hotels
Baymont by Wyndham Kingdom City
5750 Jade Rd Kingdom City MO
$98 nightly
The price is $110 total per night from Aug 16 to Aug 17
$110 total
Aug 16 - Aug 17
Total with taxes and fees
Book a stay at this business-friendly motel in Kingdom City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Ramada by Wyndham Columbia
901 Conley Rd Columbia MO
$70 nightly
The price is $79 total per night from Aug 16 to Aug 17
$79 total
Aug 16 - Aug 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Budget Inn
1309 Jefferson St Jefferson City MO
$65 nightly
The price is $75 total per night from Aug 16 to Aug 17
$75 total
Aug 16 - Aug 17
Total with taxes and fees
Stay at this motel in Jefferson City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Hickory Adams Park and McKay Park are located ...
6/10 (148 reviews)
"AC had the filter broken and the air filter was out hanging on window. Not replaced new. The room was ok but disappointed No TV the whole time, because no wifi or signal was shown on tv at all, and the way it's handled the tv dishnetwork was on top of TV was not appropriate. They need a lot of remodel ..."
Reviewed on Jul 24, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Family Friendly Hotels in Columbia
Glenn Acres Farm, Fishing and Relaxing, a Place Everyone Loves!
Columbia MO
Stay at this vacation home in Columbia. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Lakeview Mall and Eastport Park are located ...
9.8/10 Exceptional! (102 reviews)
"Beautiful home & beautiful property. Minutes from the highway. Would come back again!"
Reviewed on Jun 28, 2026
Wingate by Wyndham - Columbia
3101 Wingate Ct Columbia MO
$85 nightly
The price is $96 total per night from Aug 23 to Aug 24
$96 total
Aug 23 - Aug 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Country Inn & Suites by Radisson, Columbia, MO
817 N Keene St Columbia MO
$80 nightly
The price is $90 total per night from Sep 6 to Sep 7
$90 total
Sep 6 - Sep 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
TYS to COU Route Info
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TYS Address & GPS
Address:
2055 Alcoa Highway
Knoxville TN, 37701
United States
IATA Code:
TYS
Longitude:
-83.989729
Latitude:
35.80565
Time Zone:
America/New_York
COU Address & GPS
Address:
Route 1
Columbia MO, 65201
United States
IATA Code:
COU
Longitude:
-92.219167
Latitude:
38.813611
Time Zone:
America/Chicago
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- Fulton County Airport (FTY)
- Pike County - Hatcher Field Airport (PVL)
- Nashville Intl. Airport (BNA)
- Hartsfield-Jackson Atlanta Intl. Airport (ATL)
Frequently asked questions
Map To Nearby Hotels
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.