Cheap flights from MLA to FLO (Malta Intl. to Florence Regional)

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Hotel Ideas near Florence Regional

Airport Hotels near Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
$100 nightly
The price is $112 total per night from Dec 22 to Dec 23
$112 total
Dec 22 - Dec 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,006 reviews)
I wish Hyatt Place would upgrade the scramble egg on the menu. The powdered eggs are not very good. It's not the staff's fault. I'm sure it is a corporate decision. Step up the breakfast menu.

Reviewed on Dec 13, 2025

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St Florence SC
$130 nightly
The price is $146 total per night from Dec 28 to Dec 29
$146 total
Dec 28 - Dec 29
Total with taxes and fees
Book a stay at this spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (603 reviews)
Room spotless. Staff courteous. 👍

Reviewed on Dec 14, 2025

Hotel Florence, Tapestry Collection by Hilton
Walking distance from one of South Carolina's top Medical centers.

Walking distance from one of South Carolina's top Medical centers.

Florence SC
$208 nightly
The price is $233 total per night from Dec 16 to Dec 17
$233 total
Dec 16 - Dec 17
Total with taxes and fees
Stay at this vacation home in Florence. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Old Greenwood Athletic Park and Drs Bruce and ...
9.8/10 Exceptional! (41 reviews)
Everything was great!

Reviewed on Nov 10, 2025

Walking distance from one of South Carolina's top Medical centers.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels In Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
$62 nightly
The price is $70 total per night from Dec 16 to Dec 17
$70 total
Dec 16 - Dec 17
Total with taxes and fees
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,493 reviews)
Rooms were spacious and clean. Usual continental breakfast with waffles.

Reviewed on Dec 13, 2025

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
$85 nightly
The price is $95 total per night from Dec 23 to Dec 24
$95 total
Dec 23 - Dec 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,195 reviews)
Clean new good hotel

Reviewed on Dec 15, 2025

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
$97 nightly
The price is $109 total per night from Dec 30 to Dec 31
$109 total
Dec 30 - Dec 31
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,161 reviews)
The room was clean, the staff were friendly and the bed was the most comfortable I've had in a hotel in a long time. I appreciated the pet friendliness and the location is tucked away in a quiet area but close to I-95 with plenty of parking.

Reviewed on Dec 9, 2025

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Low Priced Florence Hotels

Red Roof Inn Florence - Civic Center

Red Roof Inn Florence - Civic Center

2 out of 5
2690 David H McLeod Boulevard Florence SC
$56 nightly
The price is $63 total per night from Dec 21 to Dec 22
$63 total
Dec 21 - Dec 22
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.6/10 (1,000 reviews)
room was decent

Reviewed on Nov 23, 2025

Red Roof Inn Florence - Civic Center
Budget Inn Timmonsville

Budget Inn Timmonsville

2 out of 5
2200 Cale Yarborough Highway Timmonsville SC
$61 nightly
The price is $68 total per night from Dec 16 to Dec 17
$68 total
Dec 16 - Dec 17
Total with taxes and fees
Stay at this motel in Timmonsville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Florence Motor Speedway is located nearby.
7/10 Good! (320 reviews)
very clean

Reviewed on Oct 16, 2025

Budget Inn Timmonsville
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$62 nightly
The price is $69 total per night from Dec 16 to Dec 17
$69 total
Dec 16 - Dec 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,002 reviews)
Everything was good except tv issues

Reviewed on Dec 10, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Family Friendly Hotels in Florence

Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
$103 nightly
The price is $116 total per night from Dec 23 to Dec 24
$116 total
Dec 23 - Dec 24
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,007 reviews)
Great breakfast buffett

Reviewed on Dec 7, 2025

Home2 Suites by Hilton Florence, SC
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

2.5 out of 5
1739 Mandeville Rd Florence SC
$95 nightly
The price is $106 total per night from Dec 22 to Dec 23
$106 total
Dec 22 - Dec 23
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (22 reviews)
Friendly staff and clean environment

Reviewed on Dec 9, 2025

Spark by Hilton Florence North I-95, SC
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
$62 nightly
The price is $69 total per night from Dec 16 to Dec 17
$69 total
Dec 16 - Dec 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,002 reviews)
Everything was good except tv issues

Reviewed on Dec 10, 2025

Days Inn by Wyndham Florence Near Civic Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

MLA to FLO Route Info

Origin Airport
Destination Airport
Number Of Airlines Serving
Distance
Shortest Flight Departure Time
Shortest Flight Departure Date
MLA Address & GPS
Address:
Malta ,
Malta
IATA Code:
MLA
Longitude:
14.495401
Latitude:
35.849776
Time Zone:
Europe/Malta
FLO Address & GPS
Address:
2100 Terminal Drive
Florence SC, 29501
United States
IATA Code:
FLO
Longitude:
-79.724444
Latitude:
34.188889
Time Zone:
America/New_York

Map To Nearby Hotels

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

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Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.