$27 Cheap flight deals from Cali (CLO) to Medellin (MDE)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Cali to Medellin

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Feb 1 - Tue, Feb 3
CLO
Alfonso Bonilla Aragon Intl.
MDE
José María Córdova Intl.
$115 Roundtrip, found 21 hours ago
$115
Roundtrip
found 21 hours ago
Select LATAM Airlines Group flight, departing Sun, Feb 1 from Alfonso Bonilla Aragon Intl. to José María Córdova Intl., returning Tue, Feb 3, priced at $115 found 21 hours ago

Airfares from $27 One Way, $54 Round Trip from Cali to Medellin

Prices starting at $54 for return flights and $27 for one-way flights to Medellin were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Feb 18 - Tue, Mar 3
CLO
Cali
MDE
Medellin
$54 Roundtrip, found 23 hours ago
$54
Roundtrip
found 23 hours ago
Select Jetsmart SPA flight, departing Wed, Feb 18 from Cali to Medellin, returning Tue, Mar 3, priced at $54 found 23 hours ago
Fri, Mar 13 - Mon, Mar 16
CLO
Cali
MDE
Medellin
$54 Roundtrip, found 4 days ago
$54
Roundtrip
found 4 days ago
Select Jetsmart SPA flight, departing Fri, Mar 13 from Cali to Medellin, returning Mon, Mar 16, priced at $54 found 4 days ago
Wed, Feb 18 - Tue, Mar 3
CLO
Cali
MDE
Medellin
$74 Roundtrip, found 23 hours ago
$74
Roundtrip
found 23 hours ago
Select Jetsmart SPA flight, departing Wed, Feb 18 from Cali to Medellin, returning Tue, Mar 3, priced at $74 found 23 hours ago
Mon, Mar 2 - Thu, Mar 5
CLO
Cali
MDE
Medellin
$75 Roundtrip, found 1 hour ago
$75
Roundtrip
found 1 hour ago
Select Jetsmart SPA flight, departing Mon, Mar 2 from Cali to Medellin, returning Thu, Mar 5, priced at $75 found 1 hour ago
Sun, Feb 1 - Mon, Feb 9
CLO
Cali
MDE
Medellin
$78 Roundtrip, found 4 days ago
$78
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Sun, Feb 1 from Cali to Medellin, returning Mon, Feb 9, priced at $78 found 4 days ago

Medellin economy flight packages

Price found within the past 48 hours. Click for updated prices.
4 Sur Hotel
3.0-star property

4 Sur Hotel

9.6/10 Exceptional! (197 reviews)

Mar 18 - Mar 24

6 night stay

Cali (CLO) to Medellín (MDE)

B & H Airlines • Roundtrip • Coach
Price was $512, price is now $239 per person
$239
per person
found 1 day ago
Very cool hotel and very nice staff

Reviewed on Jun 7, 2024

Hotel Du Parc
4.5-star property

Hotel Du Parc

9.4/10 Exceptional! (1,001 reviews)

Mar 19 - Mar 25

6 night stay

Cali (CLO) to Medellín (MDE)

B & H Airlines • Roundtrip • Coach
Price was $808, price is now $365 per person
$365
per person
just found
The staff was awesome, super friendly and helpful. Man, special kudos to Edwin, fantastic personality and awesome human being. Alejandro too and Carlos too.

Reviewed on Jan 1, 2026

The Morgana Poblado Suites Hotel
3.5-star property

The Morgana Poblado Suites Hotel

8.8/10 Excellent! (855 reviews)

Mar 19 - Mar 25

6 night stay

Cali (CLO) to Medellín (MDE)

B & H Airlines • Roundtrip • Coach
Price was $533, price is now $250 per person
$250
per person
just found
An Excellent Experience From the moment we arrived, the staff was incredibly kind and attentive. They were always ready to help with anything we needed, making our stay even more enjoyable. The place itself is very peaceful, perfect for relaxing and disconnecting. There’s a calm atmosphere that truly allows you to enjoy the surroundings. Without a doubt, it’s a place I would return to and highly recommend.

Reviewed on Oct 13, 2025

Don't see what you're looking for?
See all available trips from Cali to Medellin
View all trips

More About Flying To Medellin from Cali

Route Information for Flights from Cali to Medellin

Origin Airport IATA Code
CLO
Destination Airport IATA Code
MDE
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Cali to Medellin

Great Deals on Flights From Cali to Medellin

Spend more of your time and money at Medellin instead of sitting at your computer, searching for discount Cali to Medellin flights. This is why Orbitz makes it easy for you to check out destinations, plan your trip, and book your air fare, hotel, car rental, and more in just one place. Our low price guarantee means that you get great deals on flights from Cali to Medellin.

Flights That Fit Your Budget

Traveling on a budget? Not to worry if you are using Orbitz. We monitor thousands of fares to make sure we show you the best air ticket prices available for your travel dates. Besides amazing prices on Cali to Medellin flights, we offer you great deals on hotels, vacation packages, and last-minute getaways for the perfect trip.

Orbitz customers can receive credit for frequent flyer miles and points. Simply provide your frequent flyer details when you book qualifying Cali to Medellin flights with Orbitz.

Search for Flights from Cali to Medellin on the Go

Orbitz offers free mobile apps for iPad, iPhone, and Android-based devices, so even the busiest trip-planner can research and book flights from Cali to Medellin. Find cheap Cali to Medellin flights, research local festivities and attractions, and book reservations while sitting in the salon. Orbitz will also update you on flight delays with free alerts sent to your mobile phone or email address, so you’re never left in the dark.

Frequently asked questions

Are there non-stop flights from Cali to Medellin?
There are 3 airlines that offer nonstop services from Cali Airport to Medellin (MDE-Jose Maria Cordova Intl.), so get ready to hit that "book" button. One of these carriers will have the flight you're looking for:

  • LATAM Airlines
  • Viva Air Colombia
  • Avianca

What is the shortest flight from Cali to Medellin?
If the weather is good and all goes as scheduled, you could be coming in to land at Medellin (MDE-Jose Maria Cordova Intl.) from Alfonso Bonilla Aragon Intl. Airport (CLO) in only 49 minutes. With such a speedy flight time, contemplate taking hand luggage only.
What airlines fly from Cali to Medellin most frequently?
The airlines that fly frequently between Cali Airport and MDE include LATAM Airlines (LA). This well-known option offers 86 flights on the route each month. Viva Air Colombia (VH) will also take you to your destination in comfort. Offering 69 flights every month between Cali and Medellin, it's another popular airline to look into.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.