$335 Cheap flight deals from Grand Cayman (GCM) to Panama City (PTY)

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This Weekend's Flight Deals from Grand Cayman to Panama City

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 18 - Thu, Jul 24
GCM
Owen Roberts Intl.
PTY
Tocumen Intl.
$603 Roundtrip, found 1 day ago
$603
Roundtrip
found 1 day ago
Select Cayman Airways flight, departing Fri, Jul 18 from Owen Roberts Intl. to Tocumen Intl., returning Thu, Jul 24, priced at $603 found 1 day ago

Airfares from $335 One Way, $458 Round Trip from Grand Cayman to Panama City

Prices starting at $458 for return flights and $335 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Aug 11 - Mon, Aug 18
GCM
Grand Cayman
PTY
Panama City
$458 Roundtrip, found 6 days ago
$458
Roundtrip
found 6 days ago
Select Cayman Airways flight, departing Mon, Aug 11 from Grand Cayman to Panama City, returning Mon, Aug 18, priced at $458 found 6 days ago
Thu, Aug 14 - Mon, Aug 18
GCM
Grand Cayman
PTY
Panama City
$489 Roundtrip, found 1 day ago
$489
Roundtrip
found 1 day ago
Select Cayman Airways flight, departing Thu, Aug 14 from Grand Cayman to Panama City, returning Mon, Aug 18, priced at $489 found 1 day ago
Thu, Oct 16 - Mon, Oct 20
GCM
Grand Cayman
PTY
Panama City
$547 Roundtrip, found 3 days ago
$547
Roundtrip
found 3 days ago
Select Cayman Airways flight, departing Thu, Oct 16 from Grand Cayman to Panama City, returning Mon, Oct 20, priced at $547 found 3 days ago
Mon, Jul 14 - Mon, Jul 21
GCM
Grand Cayman
PTY
Panama City
$549 Roundtrip, found 1 day ago
$549
Roundtrip
found 1 day ago
Select Cayman Airways flight, departing Mon, Jul 14 from Grand Cayman to Panama City, returning Mon, Jul 21, priced at $549 found 1 day ago
Mon, Oct 27 - Thu, Oct 30
GCM
Grand Cayman
PTY
Panama City
$599 Roundtrip, found 8 hours ago
$599
Roundtrip
found 8 hours ago
Select Cayman Airways flight, departing Mon, Oct 27 from Grand Cayman to Panama City, returning Thu, Oct 30, priced at $599 found 8 hours ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá
4.5-star property

Megapolis Hotel Panamá

8.4/10 Very Good! (936 reviews)

Aug 21 - Aug 25

4 night stay

George Town (GCM) to Panama City (PTY)

Cayman Airways • Roundtrip • Coach
per person
found 14 hours ago
Big hotel. Uber are very easy and cheap to get

Reviewed on Jul 9, 2025

Central Hotel Panama Casco Viejo
4.0-star property

Central Hotel Panama Casco Viejo

9/10 Wonderful! (925 reviews)

Aug 21 - Aug 25

4 night stay

George Town (GCM) to Panama City (PTY)

Cayman Airways • Roundtrip • Coach
Save 100% on your flight
per person
found 14 hours ago
Kimberly at the Front Desk was wonderful!

Reviewed on Jun 8, 2025

Waldorf Astoria Panama
5.0-star property

Waldorf Astoria Panama

9/10 Wonderful! (1,002 reviews)

Aug 21 - Aug 25

4 night stay

George Town (GCM) to Panama City (PTY)

Cayman Airways • Roundtrip • Coach
per person
found 14 hours ago
Gustavo was so polite and made us feel so welcomed after a long day of travel.

Reviewed on Apr 19, 2025

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More About Flying To Panama City from Grand Cayman

Route Information for Flights from Grand Cayman to Panama City

Origin Airport IATA Code
GCM
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Grand Cayman to Panama City

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Frequently asked questions

What is the shortest flight from Grand Cayman to Panama City?
The fastest flight from Owen Roberts Intl. Airport (GCM) to Tocumen Intl. Airport (PTY) is 4 hours and 36 minutes. Slip a few things into your hand luggage to help pass the time, like that new best-seller or some Sudoku puzzles.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.