$421 Cheap flight deals from Grand Cayman (GCM) to Panama City (PTY)

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Airfares from $421 One Way, $432 Round Trip from Grand Cayman to Panama City

Prices starting at $432 for return flights and $421 for one-way flights to Panama City were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Apr 30 - Mon, May 4
GCM
Grand Cayman
PTY
Panama City
$432 Roundtrip, found 1 day ago
$432
Roundtrip
found 1 day ago
Select Cayman Airways flight, departing Thu, Apr 30 from Grand Cayman to Panama City, returning Mon, May 4, priced at $432 found 1 day ago
Thu, Apr 2 - Mon, Apr 6
GCM
Grand Cayman
PTY
Panama City
$464 Roundtrip, found 6 days ago
$464
Roundtrip
found 6 days ago
Select Cayman Airways flight, departing Thu, Apr 2 from Grand Cayman to Panama City, returning Mon, Apr 6, priced at $464 found 6 days ago
Mon, Mar 23 - Thu, Apr 9
GCM
Grand Cayman
PTY
Panama City
$495 Roundtrip, found 3 days ago
$495
Roundtrip
found 3 days ago
Select Cayman Airways flight, departing Mon, Mar 23 from Grand Cayman to Panama City, returning Thu, Apr 9, priced at $495 found 3 days ago
Thu, Dec 11 - Thu, Dec 18
GCM
Grand Cayman
PTY
Panama City
$497 Roundtrip, found 2 days ago
$497
Roundtrip
found 2 days ago
Select Cayman Airways flight, departing Thu, Dec 11 from Grand Cayman to Panama City, returning Thu, Dec 18, priced at $497 found 2 days ago
Wed, Dec 17 - Thu, Jan 1
GCM
Grand Cayman
PTY
Panama City
$523 Roundtrip, found 5 days ago
$523
Roundtrip
found 5 days ago
Select Cayman Airways flight, departing Wed, Dec 17 from Grand Cayman to Panama City, returning Thu, Jan 1, priced at $523 found 5 days ago

Panama City economy flight packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
5.0-star property

Hotel Riu Plaza Panama

9/10 Wonderful! (4,515 reviews)

Jan 22 - Jan 26

4 night stay

George Town (GCM) to Panama City (PTY)

Cayman Airways • Roundtrip • Coach
Price was $940, price is now $724 per person
$724
per person
found 8 hours ago
Didn’t know anything about airport shittle

Reviewed on Nov 22, 2025

Riande Aeropuerto Hotel & Casino
4.0-star property

Riande Aeropuerto Hotel & Casino

8.6/10 Excellent! (1,884 reviews)

Jan 22 - Jan 26

4 night stay

George Town (GCM) to Panama City (PTY)

Cayman Airways • Roundtrip • Coach
Price was $962, price is now $762 per person
$762
per person
found 8 hours ago
The room was fine; the hotel is well maintained in spite of its age. The one problem we had was the internet really didn't reach to our room very well at all. It was impossible to stay connected from the room.

Reviewed on Nov 10, 2025

MARINN PLACE Financial District
3.5-star property

MARINN PLACE Financial District

9.2/10 Wonderful! (298 reviews)

Jan 22 - Jan 26

4 night stay

George Town (GCM) to Panama City (PTY)

Cayman Airways • Roundtrip • Coach
Price was $1,131, price is now $982 per person
$982
per person
found 8 hours ago
Only small issue, the black out curtain was misaligned. I did an adjustment.

Reviewed on Dec 16, 2024

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More About Flying To Panama City from Grand Cayman

Route Information for Flights from Grand Cayman to Panama City

Origin Airport IATA Code
GCM
Destination Airport IATA Code
PTY
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Grand Cayman to Panama City

Grand Cayman to Panama City flights are offered at fantastic discount by Orbitz. Book air tickets now and cut those extra costs out of your travel budget to ensure a rewarding travel experience. With guaranteed low prices like these, can you afford to miss this discount?

Book cheap flights from Grand Cayman to Panama City

Cheap airfares are available on flights from Grand Cayman to Panama City. Use Orbitz to find the best flights that suit both your budget and the travel times that you need. Travelers who are looking for discounted rates on domestic or international flights need to look no further than Orbitz.

Orbitz goes mobile

As the world of technology rapidly expands around us, we are continuously finding new ways to improve our services, communications, and accessibility. With our cutting-edge mobile tools now available on Android, iPhone, and tablets, you can access detailed information on your bookings for flights from Grand Cayman to Panama City at any time or anywhere. See your itinerary for your Grand Cayman to Panama City flights, baggage and gate claim details, as well as hotel deals with our easy-to-use apps.

Get a great package with your Grand Cayman to Panama City flights

With frequent updates on your flight status, including delays and changes in bookings, traveling becomes more hassle-free than ever. Not only do we offer huge discounted deals on flights from Grand Cayman to Panama City, we also have fantastic savings on vacation packages, hotel room, cruises, activities, and car rentals so you can pick and choose and create the best travel package for you.

Frequently asked questions

What is the shortest flight from Grand Cayman to Panama City?
The fastest flight from Owen Roberts Intl. Airport (GCM) to Tocumen Intl. Airport (PTY) is 4 hours and 36 minutes. Slip a few things into your hand luggage to help pass the time, like that new best-seller or some Sudoku puzzles.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.