$162 Cheap flight deals from Buffalo (BUF) to Santo Domingo (SDQ)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Buffalo to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 9 - Tue, Oct 13
BUF
Buffalo Niagara Intl.
SDQ
Las Americas Intl.
$1,177 Roundtrip, found 4 hours ago
$1,177
Roundtrip
found 4 hours ago
Select JetBlue Airways flight, departing Fri, Oct 9 from Buffalo Niagara Intl. to Las Americas Intl., returning Tue, Oct 13, priced at $1,177 found 4 hours ago

Airfares from $162 One Way, $360 Round Trip from Buffalo to Santo Domingo

Prices starting at $360 for return flights and $162 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Nov 11 - Wed, Nov 18
BUF
Buffalo
SDQ
Santo Domingo
$360 Roundtrip, found 1 day ago
$360
Roundtrip
found 1 day ago
Select United flight, departing Wed, Nov 11 from Buffalo to Santo Domingo, returning Wed, Nov 18, priced at $360 found 1 day ago
Thu, Oct 29 - Sat, Nov 7
BUF
Buffalo
SDQ
Santo Domingo
$362 Roundtrip, found 3 days ago
$362
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Oct 29 from Buffalo to Santo Domingo, returning Sat, Nov 7, priced at $362 found 3 days ago
Wed, Nov 11 - Wed, Nov 18
BUF
Buffalo
SDQ
Santo Domingo
$365 Roundtrip, found 1 day ago
$365
Roundtrip
found 1 day ago
Select United flight, departing Wed, Nov 11 from Buffalo to Santo Domingo, returning Wed, Nov 18, priced at $365 found 1 day ago
Wed, Nov 11 - Wed, Nov 18
BUF
Buffalo
SDQ
Santo Domingo
$367 Roundtrip, found 1 day ago
$367
Roundtrip
found 1 day ago
Select United flight, departing Wed, Nov 11 from Buffalo to Santo Domingo, returning Wed, Nov 18, priced at $367 found 1 day ago
Wed, Nov 11 - Wed, Nov 18
BUF
Buffalo
SDQ
Santo Domingo
$370 Roundtrip, found 1 day ago
$370
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Nov 11 from Buffalo to Santo Domingo, returning Wed, Nov 18, priced at $370 found 1 day ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Grand Cayacoa
4.5-star property

Eurostars Grand Cayacoa

8.2/10 Very Good! (662 reviews)

Nov 14 - Nov 21

7 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,572, price is now $958 per person
$958
per person
found 23 hours ago
Todo excelente, habitación de lo mejor, servicios, personal muy amable, piscina, acceso a la playa todo excelente. Quizás la comida en los platos fuertes pueden variar un poco mas, en las carnes, arroces, y/o tener otra opción para el que no le guste el arroz, que no había. Pero en sentido general, diría que de los mejores hoteles que visitamos.

Reviewed on Sep 20, 2026

Wyndham Alltra Samana All-Inclusive Resort
3.0-star property

Wyndham Alltra Samana All-Inclusive Resort

8.4/10 Very Good! (524 reviews)

Nov 14 - Nov 21

7 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

American Airlines • Non-stop roundtrip • Coach
Save 100% on your flight
Price was $1,921, price is now $1,130 per person
$1,130
per person
found 23 hours ago
Very good excelente people

Reviewed on Oct 4, 2026

Hacienda Samana Bay Hotel & Residence
5.0-star property

Hacienda Samana Bay Hotel & Residence

9.4/10 Exceptional! (420 reviews)

Nov 14 - Nov 21

7 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

American Airlines • Non-stop roundtrip • Coach
Price was $1,531, price is now $1,161 per person
$1,161
per person
found 23 hours ago
Excelente vista, limpieza impecable, personal muy amable

Reviewed on Oct 3, 2026

Don't see what you're looking for?
See all available trips from Buffalo to Santo Domingo
View all trips

More About Flying To Santo Domingo from Buffalo

Route Information for Flights from Buffalo to Santo Domingo

Origin Airport IATA Code
BUF
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Buffalo to Santo Domingo

Orbitz combines guaranteed low prices with cutting-edge mobile tools for travel from Buffalo to Santo Domingo to give you a travel experience that is second to none.

Bargain Travel at Your Fingertips

Orbitz provides the cheapest fares from Buffalo to Santo Domingo. When reserving your flight you can mix and match a range of low cost airlines for you departing and returning domestic or international flights. This way you can travel on a budget while selecting the flights that suit your schedule.

Modern Tools for Fast-Paced Travel

Orbitz makes use of the latest technology to ensure that you are always kept up-to-date on the status of your Buffalo to Santo Domingo flights. Through easy-to-use mobile Android and iPhone apps you can book low cost flights from Buffalo to Santo Domingo and choose a range of cheap hotels to stay in.

Enjoy Stress-Free Travel with Flight Alerts

Once you have booked your flights from Buffalo to Santo Domingo on Orbitz you will always be kept informed of any changes to your flight. When you opt into Orbitz’s free email and SMS alerts on your Buffalo to Santo Domingo flights you can ask Orbitz to send the flight details to up to 6 other contacts, so keeping your family and business team informed is a cinch.

Frequent Flyer Program

For loyal Orbitz customers who fly from Buffalo to Santo Domingo the chance to join our frequent flyer program is an added bonus. Simply log-on to your online account and input your frequent flyer number for future flights.

Frequently asked questions

What is the shortest flight from Buffalo to Santo Domingo?
With the journey from Buffalo Niagara Intl. Airport (BUF) to Santo Domingo Airport taking a minimum of 4 hours and 58 minutes, there's plenty of time to kick back and enjoy the ride. Treat yourself to a glass of red and get comfy in your seat with an interesting book or movie.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.