$198 Cheap flight deals from Buffalo (BUF) to Santo Domingo (SDQ)

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Airfares from $198 One Way, $454 Round Trip from Buffalo to Santo Domingo

Prices starting at $454 for return flights and $198 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Feb 15 - Fri, Feb 19
BUF
Buffalo
SDQ
Santo Domingo
$454 Roundtrip, found 4 days ago
$454
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Feb 15 from Buffalo to Santo Domingo, returning Fri, Feb 19, priced at $454 found 4 days ago
Mon, Feb 15 - Fri, Feb 19
BUF
Buffalo
SDQ
Santo Domingo
$457 Roundtrip, found 4 days ago
$457
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Feb 15 from Buffalo to Santo Domingo, returning Fri, Feb 19, priced at $457 found 4 days ago
Mon, Feb 15 - Fri, Feb 19
BUF
Buffalo
SDQ
Santo Domingo
$471 Roundtrip, found 4 days ago
$471
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Feb 15 from Buffalo to Santo Domingo, returning Fri, Feb 19, priced at $471 found 4 days ago
Mon, Feb 15 - Fri, Feb 19
BUF
Buffalo
SDQ
Santo Domingo
$494 Roundtrip, found 4 days ago
$494
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Feb 15 from Buffalo to Santo Domingo, returning Fri, Feb 19, priced at $494 found 4 days ago
Wed, Feb 17 - Mon, Feb 22
BUF
Buffalo
SDQ
Santo Domingo
$501 Roundtrip, found 4 days ago
$501
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Feb 17 from Buffalo to Santo Domingo, returning Mon, Feb 22, priced at $501 found 4 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Wyndham Alltra Samana All-Inclusive Resort
3.0-star property

Wyndham Alltra Samana All-Inclusive Resort

8.4/10 Very Good! (555 reviews)

Dec 11 - Dec 14

3 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

JetBlue Airways • Non-stop • Coach

Santo Domingo (SDQ) to Buffalo (BUF)

American Airlines • Non-stop • Coach
Price was $1,348, price is now $929 per person
$929
per person
found 2 hours ago

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,515 reviews)

Jan 2 - Jan 7

5 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

American Airlines • Non-stop roundtrip • Coach
Price was $2,221, price is now $1,270 per person
$1,270
per person
found 1 day ago
The room was clean, the staff was nice and the food was good. Our second night there, the smoke detector went off in the middle of the night multiple times. There were also quite a few brief power outages. There was a definite language barrier with only a few employees other than the front desk knowing English.

Reviewed on Nov 6, 2026

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

8.6/10 Excellent! (2,617 reviews)

Dec 26 - Jan 2

7 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

Southwest Airlines • Non-stop • Coach

Santo Domingo (SDQ) to Buffalo (BUF)

American Airlines • Non-stop • Coach
Price was $4,263, price is now $2,751 per person
$2,751
per person
found 1 day ago

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More About Flying To Santo Domingo from Buffalo

Route Information for Flights from Buffalo to Santo Domingo

Origin Airport IATA Code
BUF
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Buffalo to Santo Domingo

It has never been easier to find cheap Buffalo to Santo Domingo flights. Orbitz has some of the best deals around to save you more money on your flight, hotel, and vacation package for the trip you have been waiting for.

Plan Your Buffalo to Santo Domingo Flights on the Go

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Get the Best Deals on Buffalo to Santo Domingo Flights

Finding great deals on flights from Buffalo to Santo Domingo is a snap with Orbitz. With our guaranteed low prices, you don’t have to worry if you are getting the best prices on air tickets, hotels, and cruises. And with all that money you saved, you can enjoy your Santo Domingo vacation even more.

Pile Up Miles With Discount Air Tickets

Not only can you find great bargains on Buffalo to Santo Domingo flights, but you can rack up frequent flyer miles on the flights too. Enter your frequent flyer number on qualified flights when booking for Orbitz to see the miles pile up in your account.

Flight Alerts Keep You Informed

Stay on top of the latest updates for flights from Buffalo to Santo Domingo. We send you free email and mobile alerts to keep you informed about delays to Buffalo to Santo Domingo flights.

Frequently asked questions

What is the shortest flight from Buffalo to Santo Domingo?
With the journey from Buffalo Niagara Intl. Airport (BUF) to Santo Domingo Airport taking a minimum of 4 hours and 58 minutes, there's plenty of time to kick back and enjoy the ride. Treat yourself to a glass of red and get comfy in your seat with an interesting book or movie.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.