$186 Cheap flight deals from Buffalo (BUF) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Buffalo to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jun 26 - Wed, Jul 1
BUF
Buffalo Niagara Intl.
SDQ
Las Americas Intl.
$707 Roundtrip, found 1 day ago
$707
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Fri, Jun 26 from Buffalo Niagara Intl. to Las Americas Intl., returning Wed, Jul 1, priced at $707 found 1 day ago

Airfares from $186 One Way, $396 Round Trip from Buffalo to Santo Domingo

Prices starting at $396 for return flights and $186 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Aug 21 - Fri, Aug 28
BUF
Buffalo
SDQ
Santo Domingo
$396 Roundtrip, found 20 hours ago
$396
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Fri, Aug 21 from Buffalo to Santo Domingo, returning Fri, Aug 28, priced at $396 found 20 hours ago
Fri, Sep 11 - Sat, Sep 12
BUF
Buffalo
SDQ
Santo Domingo
$396 Roundtrip, found 6 days ago
$396
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Sep 11 from Buffalo to Santo Domingo, returning Sat, Sep 12, priced at $396 found 6 days ago
Mon, Aug 24 - Mon, Aug 31
BUF
Buffalo
SDQ
Santo Domingo
$401 Roundtrip, found 20 hours ago
$401
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Mon, Aug 24 from Buffalo to Santo Domingo, returning Mon, Aug 31, priced at $401 found 20 hours ago
Fri, Aug 21 - Fri, Aug 28
BUF
Buffalo
SDQ
Santo Domingo
$403 Roundtrip, found 20 hours ago
$403
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Fri, Aug 21 from Buffalo to Santo Domingo, returning Fri, Aug 28, priced at $403 found 20 hours ago
Sun, Aug 9 - Fri, Aug 14
BUF
Buffalo
SDQ
Santo Domingo
$407 Roundtrip, found 6 days ago
$407
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Aug 9 from Buffalo to Santo Domingo, returning Fri, Aug 14, priced at $407 found 6 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Explore La Romana - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - All Inclusive

8.4/10 Very Good! (2,693 reviews)

Jul 27 - Aug 1

5 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

American Airlines • Non-stop • Coach

Santo Domingo (SDQ) to Buffalo (BUF)

Delta • Non-stop • Coach
Save 100% on your flight
Price was $1,557, price is now $1,034 per person
$1,034
per person
found 1 day ago
Comida excelente y amabilidad por parte de todos el personal. Recomendado 100% Y mejor aún m…. La comida riquísima

Reviewed on Jun 19, 2026

HERITAGE RESIDENCES STYLE
3.0-star property

HERITAGE RESIDENCES STYLE

7.4/10 Good! (17 reviews)

Aug 9 - Aug 16

7 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

American Airlines • Non-stop • Coach

Santo Domingo (SDQ) to Buffalo (BUF)

JetBlue Airways • Non-stop • Coach
Save 100% on your flight
Price was $4,293, price is now $2,510 per person
$2,510
per person
found 1 day ago
Bahia Principe Escape Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,770 reviews)

Jul 27 - Aug 1

5 night stay

Buffalo (BUF) to Santo Domingo (SDQ)

American Airlines • Non-stop • Coach

Santo Domingo (SDQ) to Buffalo (BUF)

Delta • Non-stop • Coach
Save 100% on your flight
Price was $1,720, price is now $1,120 per person
$1,120
per person
found 1 day ago
The room was large and beautiful. The property is easy to walk and navigate and beautiful. The staff are helpful, kind and friendly. We were impressed by them. Love that the hotel has its own song and dance! The pools were great, food was great! The entertainment was great and got visitors participating. Highly recommend!

Reviewed on May 19, 2026

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More About Flying To Santo Domingo from Buffalo

Route Information for Flights from Buffalo to Santo Domingo

Origin Airport IATA Code
BUF
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Buffalo to Santo Domingo

For the best travel experience from Buffalo to Santo Domingo domestic and international travelers everywhere choose Orbitz for guaranteed low prices and cutting-edge mobile tools.

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Earn Rewards on Your Buffalo to Santo Domingo Flights

At Orbitz you can benefit from low cost travel and have your loyalty rewarded on certain types of Buffalo to Santo Domingo flights. All you need to do is enter you frequent flyer number when booking and rack up your rewards through Orbitz online on the Traveler Information page for use on future flights. You can even add your frequent flyer number to an existing reservation to start the ball rolling.

Frequently asked questions

What is the shortest flight from Buffalo to Santo Domingo?
With the journey from Buffalo Niagara Intl. Airport (BUF) to Santo Domingo Airport taking a minimum of 4 hours and 58 minutes, there's plenty of time to kick back and enjoy the ride. Treat yourself to a glass of red and get comfy in your seat with an interesting book or movie.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.