
$95 Cheap flight deals from Des Moines (DSM) to Santa Clarita (BUR)
Earn rewards on top of your airline miles with Orbitz Rewards
Many airlines offer flexible change policies
Sign up to receive text alerts about your trip
This Weekend's Flight Deals from Des Moines to Santa Clarita
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $95 One Way, $190 Round Trip from Des Moines to Santa Clarita
Prices starting at $190 for return flights and $95 for one-way flights to Santa Clarita were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Santa Clarita economy flight packages

Kawada Hotel
Apr 5 - Apr 10
Des Moines (DSM) to Los Angeles (LAX)
Los Angeles (LAX) to Des Moines (DSM)
Reviewed on Nov 28, 2025

Oceana Santa Monica, LXR Hotels & Resorts
Apr 3 - Apr 10
Des Moines (DSM) to Los Angeles (LAX)
Reviewed on Aug 22, 2020

Venice Suites
Apr 3 - Apr 10
Des Moines (DSM) to Los Angeles (LAX)
Reviewed on Feb 5, 2024
More About Flying To Santa Clarita from Des Moines
Route Information for Flights from Des Moines to Santa Clarita
Origin Airport IATA Code | DSM |
|---|---|
Destination Airport IATA Code | BUR |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Des Moines to Santa Clarita
Des Moines to Santa Clarita flights are offered at fantastic discount by Orbitz. Book air tickets now and cut those extra costs out of your travel budget to ensure a rewarding travel experience. With guaranteed low prices like these, can you afford to miss this discount?
Book cheap flights from Des Moines to Santa Clarita
Cheap airfares are available on flights from Des Moines to Santa Clarita. Use Orbitz to find the best flights that suit both your budget and the travel times that you need. Travelers who are looking for discounted rates on domestic or international flights need to look no further than Orbitz.
Orbitz goes mobile
As the world of technology rapidly expands around us, we are continuously finding new ways to improve our services, communications, and accessibility. With our cutting-edge mobile tools now available on Android, iPhone, and tablets, you can access detailed information on your bookings for flights from Des Moines to Santa Clarita at any time or anywhere. See your itinerary for your Des Moines to Santa Clarita flights, baggage and gate claim details, as well as hotel deals with our easy-to-use apps.
Get a great package with your Des Moines to Santa Clarita flights
With frequent updates on your flight status, including delays and changes in bookings, traveling becomes more hassle-free than ever. Not only do we offer huge discounted deals on flights from Des Moines to Santa Clarita, we also have fantastic savings on vacation packages, hotel room, cruises, activities, and car rentals so you can pick and choose and create the best travel package for you.
Flights from Des Moines
- Des Moines to Chicago
- Des Moines to Los Angeles
- Des Moines to New York
- Des Moines to Orlando
- Des Moines to Paris
- Des Moines to Sacramento
- Des Moines to Bucharest
- Des Moines to Atlanta
- Des Moines to Beijing
- Des Moines to Charlotte
- Des Moines to Dallas
- Des Moines to Detroit
- Des Moines to Houston
- Des Moines to London
- Des Moines to New Orleans
- Des Moines to Phoenix
- Des Moines to San Francisco
- Des Moines to Seattle
- Des Moines to Toronto
- Des Moines to Washington
Des Moines Airports
Santa Clarita Airports
More Destinations
- Flights from Miami to Sunland
- Flights from Nashville to Sunland
- Flights from New York to Sunland
- Flights from Orlando to Sunland
- Flights from Portland to Sunland
- Flights from Salt Lake City to Sunland
- Flights from Seoul to Sunland
- Flights from El Paso to Valencia
- Flights from Whitefish to Valencia
- Flights from Amsterdam to Valencia
- Flights from Atlanta to Valencia
- Flights from Boston to Valencia
- Flights from Brussels to Valencia
- Flights from Chicago to Valencia
- Flights from Detroit to Valencia
- Flights from Houston to Valencia
- Flights from London to Valencia
- Flights from Minneapolis - St. Paul to Valencia
- Flights from New York to Valencia
- Flights from Phoenix to Valencia
- Flights from Portland to Valencia
- Flights from Salt Lake City to Valencia
- Flights from San Francisco to Valencia
- Flights from St. Louis to Valencia
- Flights from Vienna to Valencia
- Flights from Sacramento to Valencia
- Flights from Fort Lauderdale to Valencia
- Flights from Newark to Valencia
- Flights from Richmond to Valencia
- Flights from Oakland to Valencia
- Flights from Reno to Valencia
- Flights from Eugene to Valencia
- Flights from Spokane to Valencia
- Flights from Charlottesville to Valencia
- Flights from Baltimore to Simi Valley
- Flights from Boston to Simi Valley
- Flights from Chicago to Simi Valley
- Flights from Columbus to Simi Valley
- Flights from Denver to Simi Valley
- Flights from Houston to Simi Valley
- Flights from Indianapolis to Simi Valley
- Flights from Kansas City to Simi Valley
- Flights from Las Vegas to Simi Valley
- Flights from London to Simi Valley
- Flights from Los Angeles to Simi Valley
- Flights from Miami to Simi Valley
- Flights from Minneapolis - St. Paul to Simi Valley
- Flights from Nashville to Simi Valley
- Flights from New York to Simi Valley
- Flights from Phoenix to Simi Valley
- Flights from Portland to Simi Valley
- Flights from Raleigh to Simi Valley
- Flights from Salt Lake City to Simi Valley
- Flights from St. Louis to Simi Valley
- Flights from Washington to Simi Valley
- Flights from Sacramento to Simi Valley
- Flights from Fort Lauderdale to Simi Valley
- Flights from Newark to Simi Valley
- Flights from Richmond to Simi Valley
- Flights from Panama City to Simi Valley
- Flights from Pensacola to Simi Valley
- Flights from Buffalo to Simi Valley
- Flights from Madison to Simi Valley
- Flights from Little Rock to Simi Valley
- Flights from Spokane to Simi Valley
- Flights from Tucson to Simi Valley
- Flights from Fresno to Simi Valley
- Flights from Grand Rapids to Simi Valley
- Flights from Lansing to Simi Valley
- Flights from Albany to Simi Valley
- Flights from Gainesville to Simi Valley
- Flights from Tallahassee to Simi Valley
- Flights from Charleston to Simi Valley
- Flights from Guadalajara to Van Nuys
- Flights from Yulara to Van Nuys
- Flights from Austin to Van Nuys
- Flights from Baltimore to Van Nuys
- Flights from Charlotte to Van Nuys
- Flights from Cleveland to Van Nuys
- Flights from Denver to Van Nuys
- Flights from Nashville to Van Nuys
- Flights from Phoenix to Van Nuys
- Flights from San Antonio to Van Nuys
- Flights from Tahoe City to Van Nuys
- Flights from Padang to Van Nuys
- Flights from Moncton to Van Nuys
- Flights from Midland to Van Nuys
- Flights from Salem to Van Nuys
- Flights from La Paz to Van Nuys
- Flights from Klamath Falls to Van Nuys
- Flights from Chongqing to Van Nuys
- Flights from Da Nang to Van Nuys
- Flights from Portland to Canyon Country
- Flights from Houston to Encino
- Flights from Las Vegas to Los Angeles
- Flights from New York to Los Angeles
- Flights from San Francisco to Los Angeles
- Flights from Detroit to Stevenson Ranch
- Flights from Salt Lake City to Stevenson Ranch
- Flights from Corpus Christi to Stevenson Ranch
Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.


