
$174 Cheap flight deals from Des Moines (DSM) to Port Saint Lucie (PBI)
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This Weekend's Flight Deals from Des Moines to Port Saint Lucie
This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Airfares from $174 One Way, $347 Round Trip from Des Moines to Port Saint Lucie
Prices starting at $347 for return flights and $174 for one-way flights to Port Saint Lucie were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Port Saint Lucie economy flight packages

Inn On The Lakes
Dec 21 - Dec 27
Des Moines (DSM) to West Palm Beach (PBI)
West Palm Beach (PBI) to Des Moines (DSM)
Reviewed on Jun 9, 2025

Marriott Hutchinson Island Beach Resort, Golf & Marina
Dec 30 - Jan 4
Des Moines (DSM) to West Palm Beach (PBI)
West Palm Beach (PBI) to Des Moines (DSM)
Reviewed on Sep 3, 2025

Oak Tree Hotel
Dec 30 - Jan 4
Des Moines (DSM) to West Palm Beach (PBI)
West Palm Beach (PBI) to Des Moines (DSM)
Reviewed on Mar 25, 2025
More About Flying To Port Saint Lucie from Des Moines
Route Information for Flights from Des Moines to Port Saint Lucie
Origin Airport IATA Code | DSM |
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Destination Airport IATA Code | PBI |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Des Moines to Port Saint Lucie
Orbitz is your one-stop source for great online deals on {origin.name} to Port Saint Lucie flights. With our cutting-edge mobile tools and low fares, you are never far from finding fantastic savings on flights from Des Moines to Port Saint Lucie.
Unbeatable Deals for Flights From Des Moines to Port Saint Lucie
If you are looking for the cheapest {origin.name} to Port Saint Lucie flights, you can save your money and your sanity by booking your air fare through Orbitz. Our low price guarantee for international and domestic flights leaves more money in your wallet to spend on activities, restaurants, attractions, and other adventures in your destination.
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Don't Miss Out on Frequent Flyer Points
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Easy Flight Cancellation
In most cases, you can cancel flights from Des Moines to Port Saint Lucie online with the same ease as you booked them.
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.
