$455 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Oct 30 - Tue, Nov 3
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$492 Roundtrip, found 2 days ago
$492
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Oct 30 from Tocumen Intl. to Las Americas Intl., returning Tue, Nov 3, priced at $492 found 2 days ago

Airfares from $455 One Way, $492 Round Trip from Panama City to Santo Domingo

Prices starting at $492 for return flights and $455 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Oct 28 - Wed, Nov 4
PTY
Panama City
SDQ
Santo Domingo
$492 Roundtrip, found 2 days ago
$492
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Oct 28 from Panama City to Santo Domingo, returning Wed, Nov 4, priced at $492 found 2 days ago
Fri, Oct 30 - Tue, Nov 3
PTY
Panama City
SDQ
Santo Domingo
$502 Roundtrip, found 2 days ago
$502
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Oct 30 from Panama City to Santo Domingo, returning Tue, Nov 3, priced at $502 found 2 days ago
Sun, Mar 7 - Sun, Mar 14
PTY
Panama City
SDQ
Santo Domingo
$571 Roundtrip, found 22 hours ago
$571
Roundtrip
found 22 hours ago
Select Copa flight, departing Sun, Mar 7 from Panama City to Santo Domingo, returning Sun, Mar 14, priced at $571 found 22 hours ago
Fri, Nov 13 - Sat, Nov 21
PTY
Panama City
SDQ
Santo Domingo
$572 Roundtrip, found 1 day ago
$572
Roundtrip
found 1 day ago
Select Copa flight, departing Fri, Nov 13 from Panama City to Santo Domingo, returning Sat, Nov 21, priced at $572 found 1 day ago
Fri, Oct 30 - Tue, Nov 3
PTY
Panama City
SDQ
Santo Domingo
$574 Roundtrip, found 2 days ago
$574
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Oct 30 from Panama City to Santo Domingo, returning Tue, Nov 3, priced at $574 found 2 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bannister Hotel & Yacht Club
4.5-star property

Bannister Hotel & Yacht Club

9/10 Wonderful! (407 reviews)

Dec 15 - Dec 22

7 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,167, price is now $956 per person
$956
per person
found 1 day ago
Hermoso lugar! Es para estar en tranquilidad total !

Reviewed on Oct 25, 2026

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,571 reviews)

Dec 15 - Dec 22

7 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $2,431, price is now $1,368 per person
$1,368
per person
found 1 day ago
The staff could not do enough for you.

Reviewed on Oct 24, 2026

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

8.6/10 Excellent! (2,628 reviews)

Dec 15 - Dec 22

7 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $2,011, price is now $1,196 per person
$1,196
per person
found 1 day ago

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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

It has never been easier to find cheap Panama City to Santo Domingo flights. Orbitz has some of the best deals around to save you more money on your flight, hotel, and vacation package for the trip you have been waiting for.

Plan Your Panama City to Santo Domingo Flights on the Go

Orbitz offers cutting-edge mobile tools that let you search and book flights anywhere. All you need is a smartphone or mobile device to find discounts on flights from Panama City to Santo Domingo. Use the app to check to make sure your flight is on time or book a last-minute cheap hotel room.

Get the Best Deals on Panama City to Santo Domingo Flights

Finding great deals on flights from Panama City to Santo Domingo is a snap with Orbitz. With our guaranteed low prices, you don’t have to worry if you are getting the best prices on air tickets, hotels, and cruises. And with all that money you saved, you can enjoy your Santo Domingo vacation even more.

Pile Up Miles With Discount Air Tickets

Not only can you find great bargains on Panama City to Santo Domingo flights, but you can rack up frequent flyer miles on the flights too. Enter your frequent flyer number on qualified flights when booking for Orbitz to see the miles pile up in your account.

Flight Alerts Keep You Informed

Stay on top of the latest updates for flights from Panama City to Santo Domingo. We send you free email and mobile alerts to keep you informed about delays to Panama City to Santo Domingo flights.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.