$270 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

Earn rewards on top of your airline miles with Orbitz Rewards

Many airlines offer flexible change policies

Sign up to receive text alerts about your trip

This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jul 4 - Thu, Aug 27
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$601 Roundtrip, found 1 day ago
$601
Roundtrip
found 1 day ago
Select avianca flight, departing Sat, Jul 4 from Tocumen Intl. to Las Americas Intl., returning Thu, Aug 27, priced at $601 found 1 day ago

Airfares from $270 One Way, $507 Round Trip from Panama City to Santo Domingo

Prices starting at $507 for return flights and $270 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Sep 12 - Sat, Sep 19
PTY
Panama City
SDQ
Santo Domingo
$507 Roundtrip, just found
$507
Roundtrip
just found
Select Copa flight, departing Sat, Sep 12 from Panama City to Santo Domingo, returning Sat, Sep 19, priced at $507 just found
Tue, Jul 7 - Wed, Jul 8
PTY
Panama City
SDQ
Santo Domingo
$515 Roundtrip, found 1 day ago
$515
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, Jul 7 from Panama City to Santo Domingo, returning Wed, Jul 8, priced at $515 found 1 day ago
Mon, Jul 6 - Wed, Jul 8
PTY
Panama City
SDQ
Santo Domingo
$517 Roundtrip, found 23 hours ago
$517
Roundtrip
found 23 hours ago
Select Copa flight, departing Mon, Jul 6 from Panama City to Santo Domingo, returning Wed, Jul 8, priced at $517 found 23 hours ago
Mon, Oct 26 - Sun, Nov 1
PTY
Panama City
SDQ
Santo Domingo
$528 Roundtrip, found 1 day ago
$528
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Oct 26 from Panama City to Santo Domingo, returning Sun, Nov 1, priced at $528 found 1 day ago
Thu, Jan 7 - Sun, Jan 10
PTY
Panama City
SDQ
Santo Domingo
$549 Roundtrip, found 4 days ago
$549
Roundtrip
found 4 days ago
Select Copa flight, departing Thu, Jan 7 from Panama City to Santo Domingo, returning Sun, Jan 10, priced at $549 found 4 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Explore La Romana - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - All Inclusive

8.4/10 Very Good! (2,696 reviews)

Aug 6 - Aug 9

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,075, price is now $761 per person
$761
per person
just found
Super!

Reviewed on Jun 30, 2026

Bahia Principe Escape Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,710 reviews)

Aug 6 - Aug 9

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,173, price is now $795 per person
$795
per person
just found
Most of the staff were very pleasant!

Reviewed on Jun 30, 2026

Don't see what you're looking for?
See all available trips from Panama City to Santo Domingo
View all trips

More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

Orbitz is your one-stop source for great online deals on {origin.name} to Santo Domingo flights. With our cutting-edge mobile tools and low fares, you are never far from finding fantastic savings on flights from Panama City to Santo Domingo.

Unbeatable Deals for Flights From Panama City to Santo Domingo

If you are looking for the cheapest {origin.name} to Santo Domingo flights, you can save your money and your sanity by booking your air fare through Orbitz. Our low price guarantee for international and domestic flights leaves more money in your wallet to spend on activities, restaurants, attractions, and other adventures in your destination.

Book Cheap Panama City to Santo Domingo Flights Anytime

There is no need to hover by your computer for the latest air ticket deals—our free mobile apps keep you informed. Find discount air fare and accommodations, research your destination, and buy bargain flights from Panama City to Santo Domingo on your Android device, iPad, or iPhone. Stay updated about any updates, disruptions, and delays to your flight by signing up for instant email or text alerts

Don't Miss Out on Frequent Flyer Points

You can still earn points or miles for your frequent flyer program when you take advantage of our low fare Panama City to Santo Domingo flights. When you book through Orbitz, you just need to provide your frequent flyer details to get credit for qualifying flights.

Easy Flight Cancellation

In most cases, you can cancel flights from Panama City to Santo Domingo online with the same ease as you booked them.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.