$295 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Mar 14 - Sat, Mar 21
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$596 Roundtrip, found 1 day ago
$596
Roundtrip
found 1 day ago
Select avianca flight, departing Sat, Mar 14 from Tocumen Intl. to Las Americas Intl., returning Sat, Mar 21, priced at $596 found 1 day ago

Airfares from $295 One Way, $495 Round Trip from Panama City to Santo Domingo

Prices starting at $495 for return flights and $295 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Mon, Apr 20 - Fri, Apr 24
PTY
Panama City
SDQ
Santo Domingo
$495 Roundtrip, found 4 days ago
$495
Roundtrip
found 4 days ago
Select Copa flight, departing Mon, Apr 20 from Panama City to Santo Domingo, returning Fri, Apr 24, priced at $495 found 4 days ago
Mon, Apr 20 - Fri, Apr 24
PTY
Panama City
SDQ
Santo Domingo
$506 Roundtrip, found 4 days ago
$506
Roundtrip
found 4 days ago
Select Copa flight, departing Mon, Apr 20 from Panama City to Santo Domingo, returning Fri, Apr 24, priced at $506 found 4 days ago
Mon, Apr 20 - Fri, Apr 24
PTY
Panama City
SDQ
Santo Domingo
$517 Roundtrip, found 4 days ago
$517
Roundtrip
found 4 days ago
Select Copa flight, departing Mon, Apr 20 from Panama City to Santo Domingo, returning Fri, Apr 24, priced at $517 found 4 days ago
Sun, May 3 - Sun, May 17
PTY
Panama City
SDQ
Santo Domingo
$547 Roundtrip, found 2 days ago
$547
Roundtrip
found 2 days ago
Select avianca flight, departing Sun, May 3 from Panama City to Santo Domingo, returning Sun, May 17, priced at $547 found 2 days ago
Mon, Mar 16 - Sat, Mar 21
PTY
Panama City
SDQ
Santo Domingo
$555 Roundtrip, found 2 days ago
$555
Roundtrip
found 2 days ago
Select avianca flight, departing Mon, Mar 16 from Panama City to Santo Domingo, returning Sat, Mar 21, priced at $555 found 2 days ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Luca Hotel by Heritage Residences Signature Collection
3.5-star property

Luca Hotel by Heritage Residences Signature Collection

9.2/10 Wonderful! (737 reviews)

Apr 20 - Apr 23

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $833, price is now $705 per person
$705
per person
found 1 day ago
Professional staff, central location and delicious breakfast!

Reviewed on Oct 12, 2025

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,698 reviews)

Apr 20 - Apr 23

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,314, price is now $880 per person
$880
per person
found 1 day ago
Luxury is definitely a good way to describe. Was more than expected when considering the price! Excellent deal. Staff went above and beyond and food exquisite. Maria and Enervira are two on a long list that created fantastico memories ... The landscape plants and statues such a beautiful place

Reviewed on Oct 20, 2025

Santo Domingo Bay Convention Resort & Casino
4.5-star property

Santo Domingo Bay Convention Resort & Casino

8.2/10 Very Good! (80 reviews)

Apr 20 - Apr 23

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $970, price is now $784 per person
$784
per person
found 1 day ago
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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

If you feel you cannot afford the costs involved to your dream trip to a local or international destination happen, think again! Orbitz gives you incredible deals on flights from Panama City to Santo Domingo. Now you can book guaranteed low fares for Panama City to Santo Domingo flights and plan your trip with confidence.

Great deals on flights from Panama City to Santo Domingo

Cheap airfares on Panama City to Santo Domingo flights allow you to stick to your budget and still have a great trip. We give you guaranteed low prices and make it easy to research and book discount flights using our website. Additionally, you can add your frequent flyer numbers to your Orbitz account profile, and this information will automatically be included on all your future reservations for qualified flights from Panama City to Santo Domingo.

Cutting-edge mobile tools make travel easy

Now you can access your flight details on-the-go using your Android and iPhone phones and tablets. Book flights from Panama City to Santo Domingo directly from your mobile phone or easily check your flight status and baggage claim details or book exclusive mobile hotel deals.

Panama City to Santo Domingo flights at discounted rates

Finding flights at the right prices can be difficult if you are not sure where to look. Don’t ruin your trip by spending more on your flights than your budget allows. Orbitz gives you guaranteed low fares on Panama City to Santo Domingo flights and amazing discount offers on car rentals, hotels, and even fun activities in your destination. Your dream trip is more affordable than ever with Orbitz.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.