$269 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Jan 3 - Tue, Jan 20
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$622 Roundtrip, found 1 day ago
$622
Roundtrip
found 1 day ago
Select Copa flight, departing Sat, Jan 3 from Tocumen Intl. to Las Americas Intl., returning Tue, Jan 20, priced at $622 found 1 day ago

Airfares from $269 One Way, $461 Round Trip from Panama City to Santo Domingo

Prices starting at $461 for return flights and $269 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Jan 21 - Fri, Feb 6
PTY
Panama City
SDQ
Santo Domingo
$461 Roundtrip, found 1 day ago
$461
Roundtrip
found 1 day ago
Select Copa flight, departing Wed, Jan 21 from Panama City to Santo Domingo, returning Fri, Feb 6, priced at $461 found 1 day ago
Mon, Jun 15 - Thu, Jun 25
PTY
Panama City
SDQ
Santo Domingo
$495 Roundtrip, just found
$495
Roundtrip
just found
Select avianca flight, departing Mon, Jun 15 from Panama City to Santo Domingo, returning Thu, Jun 25, priced at $495 just found
Tue, Mar 10 - Sun, Mar 22
PTY
Panama City
SDQ
Santo Domingo
$497 Roundtrip, found 3 hours ago
$497
Roundtrip
found 3 hours ago
Select avianca flight, departing Tue, Mar 10 from Panama City to Santo Domingo, returning Sun, Mar 22, priced at $497 found 3 hours ago
Wed, Jan 14 - Fri, Jan 30
PTY
Panama City
SDQ
Santo Domingo
$504 Roundtrip, found 1 day ago
$504
Roundtrip
found 1 day ago
Select Copa flight, departing Wed, Jan 14 from Panama City to Santo Domingo, returning Fri, Jan 30, priced at $504 found 1 day ago
Fri, Jan 16 - Mon, Jan 19
PTY
Panama City
SDQ
Santo Domingo
$517 Roundtrip, found 20 hours ago
$517
Roundtrip
found 20 hours ago
Select avianca flight, departing Fri, Jan 16 from Panama City to Santo Domingo, returning Mon, Jan 19, priced at $517 found 20 hours ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Grand Samana - Adults Only
4.5-star property

Bahia Principe Grand Samana - Adults Only

8.8/10 Excellent! (624 reviews)

Feb 14 - Feb 18

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,737, price is now $1,094 per person
$1,094
per person
found 11 hours ago
Beautiful hotel, friendly staff, Room had an amazing view of the ocean. The food was far better then expected and alcohol selection was also good. My overall stay was amazing, got the rest i needed. I would definitely recommend the resort to anyone.

Reviewed on Dec 18, 2018

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive
4.5-star property

Bahia Principe Luxury Bouganville - Adults Only - All Inclusive

8.8/10 Excellent! (2,770 reviews)

Feb 14 - Feb 18

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,836, price is now $1,134 per person
$1,134
per person
found 11 hours ago
Luxury is definitely a good way to describe. Was more than expected when considering the price! Excellent deal. Staff went above and beyond and food exquisite. Maria and Enervira are two on a long list that created fantastico memories ... The landscape plants and statues such a beautiful place

Reviewed on Oct 20, 2025

Eurostars Grand Cayacoa
4.5-star property

Eurostars Grand Cayacoa

8.2/10 Very Good! (573 reviews)

Feb 14 - Feb 18

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,583, price is now $1,102 per person
$1,102
per person
found 11 hours ago
Beautiful people, awesome place and service! Very much pleased 😀

Reviewed on Jan 29, 2024

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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

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With the Orbitz mobile apps for Android and iPhone, you no longer have to be sitting at your desk to book Panama City to Santo Domingo flights. With a few easy clicks, you can book your flights, research hotel rooms, and check your flight status and other important flight information.

Easily Plan Your Vacation

Not only does Orbitz offer great prices on flights from Panama City to Santo Domingo, but you will also find fantastic deals on hotels, cruises, and vacation activities. Never miss out on that dream trip or waste hours waiting in long lines—you can buy tickets to attraction in advance with Orbitz to guarantee admission to your favorite places.

Best Deals At Your Fingertips

Orbitz combines low prices on Panama City to Santo Domingo flights with discounts on quality hotels. Using Orbitz’s Display Matrix, you can see all your options and savings easily. With our low price guarantee, you know you have the best deals at your fingertips.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.