$344 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Oct 4 - Wed, Oct 7
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$635 Roundtrip, found 1 day ago
$635
Roundtrip
found 1 day ago
Select Copa flight, departing Sun, Oct 4 from Tocumen Intl. to Las Americas Intl., returning Wed, Oct 7, priced at $635 found 1 day ago

Airfares from $344 One Way, $492 Round Trip from Panama City to Santo Domingo

Prices starting at $492 for return flights and $344 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Oct 31 - Wed, Nov 4
PTY
Panama City
SDQ
Santo Domingo
$492 Roundtrip, found 13 hours ago
$492
Roundtrip
found 13 hours ago
Select Copa flight, departing Sat, Oct 31 from Panama City to Santo Domingo, returning Wed, Nov 4, priced at $492 found 13 hours ago
Sat, Oct 31 - Wed, Nov 4
PTY
Panama City
SDQ
Santo Domingo
$502 Roundtrip, found 13 hours ago
$502
Roundtrip
found 13 hours ago
Select Copa flight, departing Sat, Oct 31 from Panama City to Santo Domingo, returning Wed, Nov 4, priced at $502 found 13 hours ago
Mon, Oct 26 - Sat, Oct 31
PTY
Panama City
SDQ
Santo Domingo
$513 Roundtrip, found 14 hours ago
$513
Roundtrip
found 14 hours ago
Select Copa flight, departing Mon, Oct 26 from Panama City to Santo Domingo, returning Sat, Oct 31, priced at $513 found 14 hours ago
Mon, Oct 26 - Sat, Oct 31
PTY
Panama City
SDQ
Santo Domingo
$531 Roundtrip, found 14 hours ago
$531
Roundtrip
found 14 hours ago
Select Copa flight, departing Mon, Oct 26 from Panama City to Santo Domingo, returning Sat, Oct 31, priced at $531 found 14 hours ago
Sat, Oct 31 - Wed, Nov 4
PTY
Panama City
SDQ
Santo Domingo
$542 Roundtrip, found 13 hours ago
$542
Roundtrip
found 13 hours ago
Select Copa flight, departing Sat, Oct 31 from Panama City to Santo Domingo, returning Wed, Nov 4, priced at $542 found 13 hours ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Stay Here Suites
4.5-star property

Stay Here Suites

9/10 Wonderful! (266 reviews)

Nov 11 - Nov 16

5 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $946, price is now $630 per person
$630
per person
just found
This was my most terrible experience. They have put just one bottle of water . In the night when i asked for a bottle of water they denyed . The personal in reception was extremely Rude alwas on his personal cell phone . Room was dirty hair everywhere even the cleaning was denyed . Breakfast was poor but stuff in the restaurant was good . The security guard was very helpful and did a better job than the receptionist

Reviewed on Sep 26, 2026

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,616 reviews)

Nov 2 - Nov 5

3 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,339, price is now $895 per person
$895
per person
found 1 day ago
El lugar es lindo el personal es amable la comida es pasable pero la habitación el baño se inunda de agua por todos lados y el aire casi no enfría

Reviewed on Sep 27, 2026

Dominican Fiesta Hotel
4.0-star property

Dominican Fiesta Hotel

8.2/10 Very Good! (2,893 reviews)

Nov 12 - Nov 19

7 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Price was $1,059, price is now $728 per person
$728
per person
found 1 day ago
Best Always

Reviewed on Sep 27, 2026

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More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

Orbitz combines guaranteed low prices with cutting-edge mobile tools for travel from Panama City to Santo Domingo to give you a travel experience that is second to none.

Bargain Travel at Your Fingertips

Orbitz provides the cheapest fares from Panama City to Santo Domingo. When reserving your flight you can mix and match a range of low cost airlines for you departing and returning domestic or international flights. This way you can travel on a budget while selecting the flights that suit your schedule.

Modern Tools for Fast-Paced Travel

Orbitz makes use of the latest technology to ensure that you are always kept up-to-date on the status of your Panama City to Santo Domingo flights. Through easy-to-use mobile Android and iPhone apps you can book low cost flights from Panama City to Santo Domingo and choose a range of cheap hotels to stay in.

Enjoy Stress-Free Travel with Flight Alerts

Once you have booked your flights from Panama City to Santo Domingo on Orbitz you will always be kept informed of any changes to your flight. When you opt into Orbitz’s free email and SMS alerts on your Panama City to Santo Domingo flights you can ask Orbitz to send the flight details to up to 6 other contacts, so keeping your family and business team informed is a cinch.

Frequent Flyer Program

For loyal Orbitz customers who fly from Panama City to Santo Domingo the chance to join our frequent flyer program is an added bonus. Simply log-on to your online account and input your frequent flyer number for future flights.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.