$346 Cheap flight deals from Panama City (PTY) to Santo Domingo (SDQ)

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This Weekend's Flight Deals from Panama City to Santo Domingo

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, Nov 15 - Sun, Nov 22
PTY
Tocumen Intl.
SDQ
Las Americas Intl.
$601 Roundtrip, found 1 day ago
$601
Roundtrip
found 1 day ago
Select avianca flight, departing Sun, Nov 15 from Tocumen Intl. to Las Americas Intl., returning Sun, Nov 22, priced at $601 found 1 day ago

Airfares from $346 One Way, $601 Round Trip from Panama City to Santo Domingo

Prices starting at $601 for return flights and $346 for one-way flights to Santo Domingo were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Mar 5 - Wed, Mar 10
PTY
Panama City
SDQ
Santo Domingo
$601 Roundtrip, found 6 hours ago
$601
Roundtrip
found 6 hours ago
Select avianca flight, departing Fri, Mar 5 from Panama City to Santo Domingo, returning Wed, Mar 10, priced at $601 found 6 hours ago
Fri, Dec 11 - Fri, Dec 18
PTY
Panama City
SDQ
Santo Domingo
$623 Roundtrip, found 11 hours ago
$623
Roundtrip
found 11 hours ago
Select avianca flight, departing Fri, Dec 11 from Panama City to Santo Domingo, returning Fri, Dec 18, priced at $623 found 11 hours ago
Tue, Dec 1 - Fri, Dec 11
PTY
Panama City
SDQ
Santo Domingo
$639 Roundtrip, found 20 hours ago
$639
Roundtrip
found 20 hours ago
Select avianca flight, departing Tue, Dec 1 from Panama City to Santo Domingo, returning Fri, Dec 11, priced at $639 found 20 hours ago
Sat, Jul 31 - Sat, Aug 7
PTY
Panama City
SDQ
Santo Domingo
$646 Roundtrip, found 15 hours ago
$646
Roundtrip
found 15 hours ago
Select avianca flight, departing Sat, Jul 31 from Panama City to Santo Domingo, returning Sat, Aug 7, priced at $646 found 15 hours ago
Fri, Mar 5 - Wed, Mar 10
PTY
Panama City
SDQ
Santo Domingo
$648 Roundtrip, found 6 hours ago
$648
Roundtrip
found 6 hours ago
Select Aeromexico flight, departing Fri, Mar 5 from Panama City to Santo Domingo, returning Wed, Mar 10, priced at $648 found 6 hours ago

Santo Domingo economy flight packages

Price found within the past 48 hours. Click for updated prices.
Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

8.6/10 Excellent! (2,617 reviews)

Dec 15 - Dec 19

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,332, price is now $853 per person
$853
per person
found 1 day ago
Playa muy buena

Reviewed on Nov 9, 2026

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,515 reviews)

Dec 15 - Dec 19

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • Coach
Save 100% on your flight
Price was $1,572, price is now $980 per person
$980
per person
found 1 day ago
The room was clean, the staff was nice and the food was good. Our second night there, the smoke detector went off in the middle of the night multiple times. There were also quite a few brief power outages. There was a definite language barrier with only a few employees other than the front desk knowing English.

Reviewed on Nov 6, 2026

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Santo Domingo business class flight packages

Price found within the past 48 hours. Click for updated prices.
Cataleya Hotel
3.0-star property

Cataleya Hotel

8.6/10 Excellent! (449 reviews)

Dec 18 - Dec 22

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • BusinessClass
Price was $1,434, price is now $1,230 per person
$1,230
per person
found 1 day ago
For vacation time the place is excellent in the center of the city with tons of things to do. I do not recommend if you go on business. Internet is not reliable

Reviewed on Nov 10, 2026

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive
4.5-star property

Bahia Principe Escape Bouganville - Hyatt Inclusive Collection - Adults Only - All Inclusive

8.8/10 Excellent! (2,515 reviews)

Dec 18 - Dec 22

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • BusinessClass
Price was $2,186, price is now $1,595 per person
$1,595
per person
found 1 day ago
The room was clean, the staff was nice and the food was good. Our second night there, the smoke detector went off in the middle of the night multiple times. There were also quite a few brief power outages. There was a definite language barrier with only a few employees other than the front desk knowing English.

Reviewed on Nov 6, 2026

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive
4.5-star property

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

8.6/10 Excellent! (2,617 reviews)

Dec 18 - Dec 22

4 night stay

Panama City (PTY) to Santo Domingo (SDQ)

Copa • Roundtrip • BusinessClass
Price was $1,946, price is now $1,467 per person
$1,467
per person
found 1 day ago
Playa muy buena

Reviewed on Nov 9, 2026

Don't see what you're looking for?
See all available trips from Panama City to Santo Domingo
View all trips

More About Flying To Santo Domingo from Panama City

Route Information for Flights from Panama City to Santo Domingo

Origin Airport IATA Code
PTY
Destination Airport IATA Code
SDQ
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Santo Domingo

Great Deals on Flights From Panama City to Santo Domingo

Spend more of your time and money at Santo Domingo instead of sitting at your computer, searching for discount Panama City to Santo Domingo flights. This is why Orbitz makes it easy for you to check out destinations, plan your trip, and book your air fare, hotel, car rental, and more in just one place. Our low price guarantee means that you get great deals on flights from Panama City to Santo Domingo.

Flights That Fit Your Budget

Traveling on a budget? Not to worry if you are using Orbitz. We monitor thousands of fares to make sure we show you the best air ticket prices available for your travel dates. Besides amazing prices on Panama City to Santo Domingo flights, we offer you great deals on hotels, vacation packages, and last-minute getaways for the perfect trip.

Orbitz customers can receive credit for frequent flyer miles and points. Simply provide your frequent flyer details when you book qualifying Panama City to Santo Domingo flights with Orbitz.

Search for Flights from Panama City to Santo Domingo on the Go

Orbitz offers free mobile apps for iPad, iPhone, and Android-based devices, so even the busiest trip-planner can research and book flights from Panama City to Santo Domingo. Find cheap Panama City to Santo Domingo flights, research local festivities and attractions, and book reservations while sitting in the salon. Orbitz will also update you on flight delays with free alerts sent to your mobile phone or email address, so you’re never left in the dark.

Frequently asked questions

Are there non-stop flights from Panama City to Santo Domingo?
Copa Airlines will fly you straight from PTY to Santo Domingo (SDQ-Las Americas Intl.), which means you won't have to stress about swapping planes or missing your connecting flight on this route.
What is the shortest flight from Panama City to Santo Domingo?
From Panama City, the eclectic sights and sounds of Santo Domingo are at least 4 hours and 15 minutes away. Book your favorite seat, or maybe even one with a bit more legroom, and get to your destination in comfort.
What airlines fly from Panama City to Santo Domingo most frequently?
Copa Airlines is the most frequent airline servicing the Panama City to Santo Domingo route. Choose from 73 flights every month with this carrier.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.