As you can't fly straight from Omaha, NE Airport (OMA-Eppley Field) to Fort Myers, FL Airport (RSW-Southwest Florida Intl.), a flight with just one stop is the next best thing. Delta Air Lines, American Airlines and United Airlines are respected airlines that service this route.
The quickest flight time from Omaha to Fort Myers is around 3 hours and 35 minutes. Grab a refreshment from the cabin crew, perfect your travel itinerary or get to know your seat mate — you'll have the time on this medium-haul journey.