$275 Cheap flight deals from Medellín (MDE) to Santiago de los Caballeros (POP)

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Airfares from $275 One Way, $303 Round Trip from Medellín to Santiago de los Caballeros

Prices starting at $303 for return flights and $275 for one-way flights to Santiago de los Caballeros were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Aug 5 - Sat, Aug 15
MDE
Medellín
STI
Santiago de los Caballeros
$303 Roundtrip, found 3 days ago
$303
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Aug 5 from Medellín to Santiago de los Caballeros, returning Sat, Aug 15, priced at $303 found 3 days ago
Wed, Aug 5 - Sat, Aug 15
MDE
Medellín
STI
Santiago de los Caballeros
$327 Roundtrip, found 3 days ago
$327
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Aug 5 from Medellín to Santiago de los Caballeros, returning Sat, Aug 15, priced at $327 found 3 days ago
Wed, Aug 5 - Sat, Aug 15
MDE
Medellín
STI
Santiago de los Caballeros
$350 Roundtrip, found 3 days ago
$350
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Aug 5 from Medellín to Santiago de los Caballeros, returning Sat, Aug 15, priced at $350 found 3 days ago
Wed, Aug 5 - Sat, Aug 15
MDE
Medellín
STI
Santiago de los Caballeros
$384 Roundtrip, found 3 days ago
$384
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Aug 5 from Medellín to Santiago de los Caballeros, returning Sat, Aug 15, priced at $384 found 3 days ago
Wed, Aug 5 - Sat, Aug 15
MDE
Medellín
STI
Santiago de los Caballeros
$391 Roundtrip, found 3 days ago
$391
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Aug 5 from Medellín to Santiago de los Caballeros, returning Sat, Aug 15, priced at $391 found 3 days ago

Santiago de los Caballeros economy flight packages

Price found within the past 48 hours. Click for updated prices.
Lifestyle Tropical Beach Resort & Spa All Inclusive
3.0-star property

Lifestyle Tropical Beach Resort & Spa All Inclusive

6.8/10 (1,443 reviews)

Jun 6 - Jun 9

3 night stay

Medellín (MDE) to Santiago (STI)

Copa • Non-stop roundtrip • Coach
Price was $1,515, price is now $1,156 per person
$1,156
per person
found 1 day ago
Very clean rooms, highly recommended, friendly staff, good food, overall very good.

Reviewed on Feb 2, 2026

Presidential Suites by Lifestyle - All Inclusive
3.5-star property

Presidential Suites by Lifestyle - All Inclusive

7.2/10 Good! (513 reviews)

Jun 6 - Jun 9

3 night stay

Medellín (MDE) to Santiago (STI)

Copa • Non-stop roundtrip • Coach
Price was $1,852, price is now $1,284 per person
$1,284
per person
found 1 day ago
The toilets need upgrade.

Reviewed on Aug 5, 2024

Lifestyle Crown Residence Suites - All Inclusive
3.5-star property

Lifestyle Crown Residence Suites - All Inclusive

7.4/10 Good! (1,003 reviews)

Jun 6 - Jun 9

3 night stay

Medellín (MDE) to Santiago (STI)

Copa • Non-stop roundtrip • Coach
Price was $1,693, price is now $1,235 per person
$1,235
per person
found 1 day ago
Loved the wife selection of dining locations, however the pools closed at 6pm or some 6:45pm when it was still daylight out.

Reviewed on Aug 13, 2023

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More About Flying To Santiago de los Caballeros from Medellín

Route Information for Flights from Medellín to Santiago de los Caballeros

Origin Airport IATA Code
MDE
Destination Airport IATA Code
POP
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Medellín to Santiago de los Caballeros

Grab great fares on Medellín to Santiago de los Caballeros flights with Orbitz, your #1 source for discount international and domestic air tickets. Our cutting-edge mobile tools and great online search functionality make booking your next budget trip a breeze.

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Find Your Medellín to Santiago de los Caballeros Flights, Car, and Hotel in One Place

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Frequently asked questions

What is the shortest flight from Medellin to Santiago de los Caballeros?
The shortest flight time from MDE to Cibao Intl. Airport (STI) is 5 hours and 34 minutes, which gives you ample time to enjoy a drink or lose yourself in a good book.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.